Macrophages synthesize factor X and secrete factor X/Xa-containing prothrombinase activity into the surrounding medium

• Published in: Thrombosis and haemostasis Vol. 84; no. 3; p. 429
• Main Authors: Pejler, G, Lunderius, C, Tomasini-Johansson, B
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2000
• Subjects: Animals; Edetic Acid - pharmacology; Factor X - biosynthesis; Factor X - pharmacology; Factor X - secretion; Factor Xa - metabolism; Factor Xa - pharmacology; Factor Xa - secretion; Female; Humans; Kinetics; Macrophages - metabolism; Macrophages - secretion; Macrophages, Peritoneal - metabolism; Macrophages, Peritoneal - secretion; Male; Mice; Octoxynol - pharmacology; Prothrombin - metabolism; Synovial Fluid - cytology; Thromboplastin - drug effects; Thromboplastin - metabolism

Activation of the coagulation cascade, mediated by various monocyte/macrophage procoagulants, is an important component in the pathology of inflammatory disease. The type of procoagulant expressed may vary between different monocyte/macrophage subtypes and may differ depending on how the cells are t...