Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses - Innamorati, Katherine A.; Earl, Joshua P.; Barrera, Shirley C.; Ehrlich, Rachel L.; Aiyeku, Josephine; Gordon, Ari; Powell, Evan; Retchless, Adam C.; Ahmed, Azad; Sen, Bhaswati; Balashov, Sergey; Mell, Joshua Chang; et al. (Genome medicine, 2025)
Keywords: Analysis; Anopheles; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotic resistance; Antibiotics; Bacterial vaginosis; Care and treatment; Clindamycin; Clinical isolates; Comparative genomics; Distributed genome hypothesis; DNA sequencing; Drug resistance in microorganisms; Drug Resistance, Bacterial - genetics; Ethylenediaminetetraacetic acid; Female; Gardnerella vaginalis; Gardnerella vaginalis - classification; Gardnerella vaginalis - drug effects; Gardnerella vaginalis - genetics; Genes; Genital microflora; Genome, Bacterial; Genomes; Genomic analysis; Genomics; Genomics - methods; Gram-positive bacteria; Humans; Life sciences; Metadata; Metronidazole; Metronidazole - pharmacology; Metronidazole - therapeutic use; Microbial Sensitivity Tests; Microbiota; Microbiota (Symbiotic organisms); Minimum inhibitory concentration; Nitroimidazoles; Nucleotide sequencing; Opportunist infection; Pangenome; Pathogenesis; Pathogens; Patients; Phenotypes; Phylogenetics; Phylogeny; Polymerase chain reaction; Strains (organisms); Supragenome; Vagina; Vaginosis; Vaginosis, Bacterial - drug therapy; Vaginosis, Bacterial - microbiology; Virulence; Whole Genome Sequencing; United States; United States--US; Bacterial vaginosis; Gardnerella vaginalis; Distributed genome hypothesis; Molecular diagnostic; Metronidazole resistance; Antibiotic resistance; Comparative genomics; Phylogenetics; Supragenome; Pangenome