The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury

• Published in: Diabetology and metabolic syndrome Vol. 17; no. 1; pp. 154 - 15
• Main Authors: Wu, Zeng, Gao, Yu, Zuo, Chun-yue, Wang, Xiao-rong, Chen, Xiao-han, Zhou, Xiao-hong, Gao, Wei-juan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.05.2025; BioMed Central; BMC
• Subjects: Blood circulation disorders; Chronic kidney failure; Diabetes; Diabetes mellitus; Diabetic nephropathies; Diabetic nephropathy; Disease; End-stage renal disease; Endothelial dysfunction; Endothelium; Energy metabolism; Hemodynamics; Hyperglycemia; Hypoxia; Inflammation; Kidney diseases; Kidneys; Kinases; Metabolism; Microcirculation; Microvasculature; Nephropathy; Pathogenesis; Permeability; Phosphorylation; Renal function; Renal hypoxia; Review; Sapropterin dihydrochloride; Vascular diseases; Endothelial dysfunction; Microcirculation; Diabetic nephropathy; Inflammation; Renal hypoxia
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-025-01718-4

Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes mellitus (DM) and is the main cause of end-stage renal disease. Endothelial dysfunction caused by persistent hyperglycemia occurs at the initial stage of vascular disease. Moreover, persistent hyp...