Comparison of Radiation Response between 2D and 3D Cell Culture Models of Different Human Cancer Cell Lines

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 3; p. 360
• Main Authors: Raitanen, Julia, Barta, Bernadette, Hacker, Marcus, Georg, Dietmar, Balber, Theresa, Mitterhauser, Markus
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.01.2023; MDPI
• Subjects: Cancer; Cancer cells; Cancer therapies; Cell culture; Cell Culture Techniques, Three Dimensional; Cell Line; Cell lines; Cell proliferation; Cell viability; Cells; Comparative analysis; DNA damage; external photon beam (X-ray); Growth inhibition; human cancer cell lines (PC-3; Humans; Neoplasms - pathology; Radiation; radiation oncology; Radiation therapy; Radiation Tolerance; Radiobiology; Radiosensitivity; Software; Spheroids; therapy; Tumor cell lines; Tumors; X-rays; Austria; United Kingdom > UK; United States > US; Japan; Germany; external photon beam (X-ray); multicellular tumor spheroids (3D); LNCaP; radiobiology; clonogenic assay; therapy; γH2AX; radiosensitivity; radiation oncology; T-47D; resazurin assay; human cancer cell lines (PC-3

Radiation therapy is one of the most effective tools in cancer therapy. However, success varies individually, necessitating improved understanding of radiobiology. Three-dimensional (3D) tumor spheroids are increasingly gaining attention, being a superior in vitro cancer model compared to 2D cell cu...