Polo-like kinase acts as a molecular timer that safeguards the asymmetric fate of spindle microtubule-organizing centers

• Published in: eLife Vol. 9
• Main Authors: Matellán, Laura, Manzano-López, Javier, Monje-Casas, Fernando
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 02.11.2020; eLife Sciences Publications, Ltd; eLife Sciences Publications Ltd
• Subjects: aging; asymmetry; Cell Biology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; centrosome; Development and progression; Genes, Fungal; Microscopy, Fluorescence; Microtubules - physiology; MTOC; Nervous system diseases; POLO; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; SPB; Spindle Apparatus - physiology; Stem cells; Tubulin; cell biology; SPB; POLO; asymmetry; aging; centrosome; MTOC; S. cerevisiae

The microtubules that form the mitotic spindle originate from microtubule-organizing centers (MTOCs) located at either pole. After duplication, spindle MTOCs can be differentially inherited during asymmetric cell division in organisms ranging from yeast to humans. Problems with establishing predeter...