Urinary exosomal transcription factors, a new class of biomarkers for renal disease
Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models...
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| Published in | Kidney international Vol. 74; no. 5; pp. 613 - 621 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.09.2008
Nature Publishing Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls. Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot. These factors were found in the concentrated exosomal fraction, but not in whole urine. ATF3 was continuously present in urine exosomes of the rat models following acute injury at times earlier than the increase in serum creatinine. ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls. Urinary WT-1 was present in animal models before significant glomerular sclerosis and in 9/10 patients with focal segmental glomerulosclerosis but not in 8 controls. Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury. Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways. |
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| AbstractList | Urinary exosomes are excreted from all nephron segments and are a rich source of kidney injury biomarkers. Because exosomes contain intracellular proteins, we asked if transcription factors (TF) can be measured in urinary exosomes. We collected urine from two acute kidney injury (AKI) models (cisplatin or ischemia/reperfusion) and two podocyte injury models (puromycin-treated rats and podocin/Vpr transgenic mice). Human urine was obtained from patients with AKI, focal segmental glomerulosclerosis (FSGS), and matched controls. After isolating urine exosomes by differential centrifugation, activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) were detected by western blot. ATF3 was continuously detected in urine exosomes 2–24 hr after ischemia/reperfusion and in a biphasic pattern after cisplatin. In both models, urinary ATF3 was detected earlier than serum creatinine. Urinary ATF3 was detected in AKI patients but not in normal subjects or patients with chronic kidney disease (CKD). Urinary WT-1 was detected in animal models before significant glomerular sclerosis. Urinary WT-1 was detected in 9/10 FSGS patients, but not in 8 controls. Transcription factors can be detected in urine exosomes, but not in whole urine. Urinary ATF3 may be a novel renal tubular cell injury biomarker for detecting early AKI, whereas urinary WT-1 may detect early podocyte injury. Urinary exosomal TFs represent a new class of biomarkers for acute and chronic renal diseases and may offer insight into cellular regulatory pathways. Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls. Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot. These factors were found in the concentrated exosomal fraction, but not in whole urine. ATF3 was continuously present in urine exosomes of the rat models following acute injury at times earlier than the increase in serum creatinine. ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls. Urinary WT-1 was present in animal models before significant glomerular sclerosis and in 9/10 patients with focal segmental glomerulosclerosis but not in 8 controls. Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury. Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways. Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls. Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot. These factors were found in the concentrated exosomal fraction, but not in whole urine. ATF3 was continuously present in urine exosomes of the rat models following acute injury at times earlier than the increase in serum creatinine. ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls. Urinary WT-1 was present in animal models before significant glomerular sclerosis and in 9/10 patients with focal segmental glomerulosclerosis but not in 8 controls. Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury. Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways.Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls. Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot. These factors were found in the concentrated exosomal fraction, but not in whole urine. ATF3 was continuously present in urine exosomes of the rat models following acute injury at times earlier than the increase in serum creatinine. ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls. Urinary WT-1 was present in animal models before significant glomerular sclerosis and in 9/10 patients with focal segmental glomerulosclerosis but not in 8 controls. Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury. Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways. |
| Author | Hiramatsu, Noriyuki Star, Robert A. Cheruvanky, Anita Leelahavanichkul, Asada Hu, Xuzhen Doi, Kent Illei, Gabor G. Yuen, Peter S.T. Kopp, Jeffrey B. Austin, Howard A. Balow, James E. Zhou, Hua Matsumoto, Takayuki Berger, Alexandra Cho, Monique E. Chawla, Lakhmir S. |
| AuthorAffiliation | 1 Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, MD 4 Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, DC, USA 2 Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, MD 3 Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, MD |
| AuthorAffiliation_xml | – name: 2 Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, MD – name: 3 Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, MD – name: 4 Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, DC, USA – name: 1 Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, MD |
| Author_xml | – sequence: 1 givenname: Hua surname: Zhou fullname: Zhou, Hua organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 2 givenname: Anita surname: Cheruvanky fullname: Cheruvanky, Anita organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 3 givenname: Xuzhen surname: Hu fullname: Hu, Xuzhen organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 4 givenname: Takayuki surname: Matsumoto fullname: Matsumoto, Takayuki organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 5 givenname: Noriyuki surname: Hiramatsu fullname: Hiramatsu, Noriyuki organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 6 givenname: Monique E. surname: Cho fullname: Cho, Monique E. organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 7 givenname: Alexandra surname: Berger fullname: Berger, Alexandra organization: Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, District of Columbia, USA – sequence: 8 givenname: Asada surname: Leelahavanichkul fullname: Leelahavanichkul, Asada organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 9 givenname: Kent surname: Doi fullname: Doi, Kent organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 10 givenname: Lakhmir S. surname: Chawla fullname: Chawla, Lakhmir S. organization: Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, District of Columbia, USA – sequence: 11 givenname: Gabor G. surname: Illei fullname: Illei, Gabor G. organization: Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland, USA – sequence: 12 givenname: Jeffrey B. surname: Kopp fullname: Kopp, Jeffrey B. organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 13 givenname: James E. surname: Balow fullname: Balow, James E. organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 14 givenname: Howard A. surname: Austin fullname: Austin, Howard A. organization: Kidney Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland, USA – sequence: 15 givenname: Peter S.T. surname: Yuen fullname: Yuen, Peter S.T. organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA – sequence: 16 givenname: Robert A. surname: Star fullname: Star, Robert A. email: Robert_Star@nih.gov organization: Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20584320$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18509321$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1159/000080188 10.1056/NEJMoa051907 10.1046/j.1523-1755.2003.00106.x 10.1681/ASN.2004070564 10.1681/ASN.2005050512 10.1016/S0140-6736(05)74811-X 10.1093/rheumatology/kel029 10.1152/physiolgenomics.00223.2005 10.1046/j.1523-1755.2002.00633.x 10.1074/mcp.R600004-MCP200 10.1038/sj.ki.5001575 10.1002/jemt.10076 10.1038/sj.ki.5000273 10.1097/00000542-200609000-00011 10.1681/ASN.2005030236 10.1074/jbc.272.32.19943 10.1038/sj.ki.5001527 10.1093/toxsci/63.2.196 10.1097/01.ASN.0000129114.92265.32 10.1093/ndt/gfl408 10.1074/jbc.M511983200 10.1038/nature04768 10.1186/cc5713 10.1042/CS20060143 10.1038/sj.ki.5000221 10.1038/sj.ki.5001874 10.1159/000074322 10.1093/ndt/gfh574 10.1681/ASN.2005111155 10.1046/j.1523-1755.2003.00928.x 10.1681/ASN.V125900 10.1152/ajprenal.00434.2006 10.1158/0008-5472.CAN-04-2602 10.1681/ASN.2006030217 10.1152/ajprenal.00404.2002 10.1016/j.ymgme.2003.09.012 10.1046/j.1523-1755.2002.00341.x 10.1073/pnas.0403453101 10.1111/j.1600-6143.2006.01352.x 10.1681/ASN.2005020159 10.1007/s00467-006-0055-0 10.1152/ajprenal.00342.2005 10.1016/j.cca.2005.10.007 10.1152/ajprenal.00054.2002 10.1152/ajprenal.00366.2003 10.1038/sj.ki.5000073 10.1016/j.trsl.2007.01.002 10.1046/j.1365-2362.1999.00535.x 10.1159/000093961 10.1159/000101799 10.1007/s00467-006-0208-1 10.1038/sj.ki.5000410 10.1093/ndt/gfk102 10.1038/sj.ki.5002302 10.1038/ncpneph0551 10.2215/CJN.04121206 10.1016/S0272-6386(03)00744-3 10.1093/ndt/12.9.1883 |
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| Copyright | 2008 International Society of Nephrology 2008 INIST-CNRS Copyright Nature Publishing Group Sep 2008 |
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| Keywords | FSGS transcription factor WT-1 exosomes ATF3 AKI Kidney disease Urine Nephrology Urinary system disease Biological marker Biological indicator Urology Signal transduction Transcription factor ATF3 Nephropathy Exosome Renal failure Transcription factor |
| Language | English |
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| References | Yuen, Jo, Holly (bb0150) 2006; 25 Gilchrist, Thorsson, Li (bb0220) 2006; 441 Mishra, Dent, Tarabishi (bb0020) 2005; 365 Devarajan, Mishra, Supavekin (bb0155) 2003; 80 Rule, Bergstralh, Slezak (bb0085) 2006; 69 Kieran, Doran, Connolly (bb0160) 2003; 64 Nelson, Cao, Zhu (bb0290) 2005; 65 Chan, Lai, Li (bb0300) 2006; 21 du Cheyron, Daubin, Poggioli (bb0130) 2003; 42 Kanno, Kawachi, Uchida (bb0270) 2003; 95 Mehta, Kellum, Shah (bb0310) 2007; 11 Padanilam, Hammerman (bb0145) 1997; 272 Yoshida, Sugiura, Mitobe (bb0235) 2008; 19 Hiramatsu, Hiromura, Shigehara (bb0200) 2007; 18 Barisoni, Schnaper, Kopp (bb0205) 2007; 2 Wagener, Jan, Kim (bb0025) 2006; 105 Chang, Yang, Li (bb0095) 2006; 366 Parikh, Jani, Mishra (bb0030) 2006; 6 Yuen, Dunn, Miyaji (bb0315) 2004; 286 Bachorzewska-Gajewska, Malyszko, Sitniewska (bb0045) 2006; 26 Vogelmann, Nelson, Myers (bb0255) 2003; 285 Zhou, Pisitkun, Aponte (bb0075) 2006; 70 Brooks, Ageloff, Kwon (bb0180) 2003; 284 Holly, Dear, Hu (bb0065) 2006; 70 Hara, Yanagihara, Kihara (bb0115) 2005; 16 Clement, Liu, Perez-Torres (bb0245) 2007; 72 Pisitkun, Johnstone, Knepper (bb0125) 2006; 5 Zhou, Yuen, Pisitkun (bb0135) 2006; 69 Niaudet, Gubler (bb0240) 2006; 21 Molitoris, Levin, Warnock (bb0305) 2007; 3 Parikh, Mishra, Thiessen-Philbrook (bb0055) 2006; 70 Schwab, Witte, Aronow (bb0190) 2004; 24 Kubo, Miyagawa, Yamamoto (bb0110) 1999; 29 Pisitkun, Shen, Knepper (bb0120) 2004; 101 Yu, Petermann, Kunter (bb0260) 2005; 16 Bachorzewska-Gajewska, Malyszko, Sitniewska (bb0040) 2007; 22 Michaud, Kennedy (bb0170) 2007; 112 Nguyen, Devarajan (bb0080) 2007 Cheruvanky, Zhou, Pisitkun (bb0275) 2007; 292 Mishra, Ma, Kelly (bb0035) 2006; 21 Chan, Lai, Li (bb0295) 2006; 45 Muthukumar, Dadhania, Ding (bb0285) 2005; 353 Yoshida, Kurella, Beato (bb0210) 2002; 61 Zhou, Hewitt, Yuen (bb0015) 2006; 5 Molls, Savransky, Liu (bb0070) 2006; 290 Shankland (bb0250) 2006; 69 Supavekin, Zhang, Kucherlapati (bb0165) 2003; 63 Petermann, Floege (bb0265) 2007; 106 Guerra, Lopez-Fernandez, Garcia (bb0225) 2006; 281 Parikh, Abraham, Ancukiewicz (bb0050) 2005; 16 Haase (bb0280) 2006; 69 Huang, Dunn, Jayadev (bb0140) 2001; 63 Hai, Wolfgang, Marsee (bb0215) 1999; 7 Szeto, Chan, Lai (bb0105) 2005; 20 Chugh (bb0195) 2007; 149 Miyaji, Kato, Yasuda (bb0230) 2001; 12 White, Akbari, Hussain (bb0090) 2005; 16 Quaggin (bb0175) 2002; 57 Yin, Sandhu, Wolfgang (bb0185) 1997; 272 Soylemezoglu, Wild, Dalley (bb0100) 1997; 12 Hewitt, Dear, Star (bb0010) 2004; 15 Muramatsu, Tsujie, Kohda (bb0060) 2002; 62 Bachorzewska-Gajewska (10.1038/ki.2008.206_bb0045) 2006; 26 Nguyen (10.1038/ki.2008.206_bb0080) 2007 Pisitkun (10.1038/ki.2008.206_bb0125) 2006; 5 Hai (10.1038/ki.2008.206_bb0215) 1999; 7 Cheruvanky (10.1038/ki.2008.206_bb0275) 2007; 292 Michaud (10.1038/ki.2008.206_bb0170) 2007; 112 Yin (10.1038/ki.2008.206_bb0185) 1997; 272 Muthukumar (10.1038/ki.2008.206_bb0285) 2005; 353 Chan (10.1038/ki.2008.206_bb0300) 2006; 21 Mishra (10.1038/ki.2008.206_bb0020) 2005; 365 Muramatsu (10.1038/ki.2008.206_bb0060) 2002; 62 Hara (10.1038/ki.2008.206_bb0115) 2005; 16 Szeto (10.1038/ki.2008.206_bb0105) 2005; 20 Shankland (10.1038/ki.2008.206_bb0250) 2006; 69 Quaggin (10.1038/ki.2008.206_bb0175) 2002; 57 Yoshida (10.1038/ki.2008.206_bb0235) 2008; 19 Clement (10.1038/ki.2008.206_bb0245) 2007; 72 Zhou (10.1038/ki.2008.206_bb0135) 2006; 69 Mishra (10.1038/ki.2008.206_bb0035) 2006; 21 Holly (10.1038/ki.2008.206_bb0065) 2006; 70 Yuen (10.1038/ki.2008.206_bb0150) 2006; 25 du Cheyron (10.1038/ki.2008.206_bb0130) 2003; 42 Parikh (10.1038/ki.2008.206_bb0050) 2005; 16 Petermann (10.1038/ki.2008.206_bb0265) 2007; 106 Nelson (10.1038/ki.2008.206_bb0290) 2005; 65 Parikh (10.1038/ki.2008.206_bb0055) 2006; 70 Guerra (10.1038/ki.2008.206_bb0225) 2006; 281 Chang (10.1038/ki.2008.206_bb0095) 2006; 366 Supavekin (10.1038/ki.2008.206_bb0165) 2003; 63 White (10.1038/ki.2008.206_bb0090) 2005; 16 Kubo (10.1038/ki.2008.206_bb0110) 1999; 29 Hewitt (10.1038/ki.2008.206_bb0010) 2004; 15 Molitoris (10.1038/ki.2008.206_bb0305) 2007; 3 Brooks (10.1038/ki.2008.206_bb0180) 2003; 284 Niaudet (10.1038/ki.2008.206_bb0240) 2006; 21 Schwab (10.1038/ki.2008.206_bb0190) 2004; 24 Yu (10.1038/ki.2008.206_bb0260) 2005; 16 Pisitkun (10.1038/ki.2008.206_bb0120) 2004; 101 Yuen (10.1038/ki.2008.206_bb0315) 2004; 286 Haase (10.1038/ki.2008.206_bb0280) 2006; 69 Zhou (10.1038/ki.2008.206_bb0075) 2006; 70 Kanno (10.1038/ki.2008.206_bb0270) 2003; 95 Mehta (10.1038/ki.2008.206_bb0310) 2007; 11 Soylemezoglu (10.1038/ki.2008.206_bb0100) 1997; 12 Devarajan (10.1038/ki.2008.206_bb0155) 2003; 80 Kieran (10.1038/ki.2008.206_bb0160) 2003; 64 Wagener (10.1038/ki.2008.206_bb0025) 2006; 105 Bachorzewska-Gajewska (10.1038/ki.2008.206_bb0040) 2007; 22 Rule (10.1038/ki.2008.206_bb0085) 2006; 69 Miyaji (10.1038/ki.2008.206_bb0230) 2001; 12 Yoshida (10.1038/ki.2008.206_bb0210) 2002; 61 Zhou (10.1038/ki.2008.206_bb0015) 2006; 5 Padanilam (10.1038/ki.2008.206_bb0145) 1997; 272 Barisoni (10.1038/ki.2008.206_bb0205) 2007; 2 Chugh (10.1038/ki.2008.206_bb0195) 2007; 149 Chan (10.1038/ki.2008.206_bb0295) 2006; 45 Huang (10.1038/ki.2008.206_bb0140) 2001; 63 Parikh (10.1038/ki.2008.206_bb0030) 2006; 6 Vogelmann (10.1038/ki.2008.206_bb0255) 2003; 285 Molls (10.1038/ki.2008.206_bb0070) 2006; 290 Gilchrist (10.1038/ki.2008.206_bb0220) 2006; 441 Hiramatsu (10.1038/ki.2008.206_bb0200) 2007; 18 |
| References_xml | – volume: 57 start-page: 208 year: 2002 end-page: 211 ident: bb0175 article-title: Transcriptional regulation of podocyte specification and differentiation publication-title: Microsc Res Tech – volume: 65 start-page: 6151 year: 2005 end-page: 6158 ident: bb0290 article-title: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia publication-title: Cancer Res – volume: 16 start-page: 408 year: 2005 end-page: 416 ident: bb0115 article-title: Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury publication-title: J Am Soc Nephrol – volume: 69 start-page: 1471 year: 2006 end-page: 1476 ident: bb0135 article-title: Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery publication-title: Kidney Int – volume: 16 start-page: 3046 year: 2005 end-page: 3052 ident: bb0050 article-title: Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit publication-title: J Am Soc Nephrol – volume: 64 start-page: 480 year: 2003 end-page: 492 ident: bb0160 article-title: Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog publication-title: Kidney Int – volume: 63 start-page: 1714 year: 2003 end-page: 1724 ident: bb0165 article-title: Differential gene expression following early renal ischemia/reperfusion publication-title: Kidney Int – volume: 365 start-page: 1231 year: 2005 end-page: 1238 ident: bb0020 article-title: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery publication-title: Lancet – volume: 72 start-page: 337 year: 2007 end-page: 347 ident: bb0245 article-title: Early changes in gene expression that influence the course of primary glomerular disease publication-title: Kidney Int – volume: 286 start-page: F1116 year: 2004 end-page: F1119 ident: bb0315 article-title: A simplified method for HPLC determination of creatinine in mouse serum publication-title: Am J Physiol Renal Physiol – volume: 5 start-page: 63 year: 2006 end-page: 71 ident: bb0015 article-title: Acute kidney injury biomarkers-needs, present status, and future promise publication-title: NephSAP – volume: 6 start-page: 1639 year: 2006 end-page: 1645 ident: bb0030 article-title: Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation publication-title: Am J Transplant – volume: 70 start-page: 1847 year: 2006 end-page: 1857 ident: bb0065 article-title: Biomarker and drug target discovery using proteomics in a new rat model of sepsis-induced acute renal failure publication-title: Kidney Int – volume: 16 start-page: 1733 year: 2005 end-page: 1741 ident: bb0260 article-title: Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria publication-title: J Am Soc Nephrol – volume: 112 start-page: 325 year: 2007 end-page: 335 ident: bb0170 article-title: The podocyte in health and disease: insights from the mouse publication-title: Clin Sci (Lond) – volume: 353 start-page: 2342 year: 2005 end-page: 2351 ident: bb0285 article-title: Messenger RNA for FOXP3 in the urine of renal-allograft recipients publication-title: N Engl J Med – year: 2007 ident: bb0080 article-title: Biomarkers for the early detection of acute kidney injury publication-title: Pediatr Nephrol – volume: 21 start-page: 856 year: 2006 end-page: 863 ident: bb0035 article-title: Kidney NGAL is a novel early marker of acute injury following transplantation publication-title: Pediatr Nephrol – volume: 61 start-page: 1646 year: 2002 end-page: 1654 ident: bb0210 article-title: Monitoring changes in gene expression in renal ischemia–reperfusion in the rat publication-title: Kidney Int – volume: 106 start-page: c61 year: 2007 end-page: c66 ident: bb0265 article-title: Podocyte damage resulting in podocyturia: a potential diagnostic marker to assess glomerular disease activity publication-title: Nephron Clin Pract – volume: 80 start-page: 365 year: 2003 end-page: 376 ident: bb0155 article-title: Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics publication-title: Mol Genet Metab – volume: 70 start-page: 1847 year: 2006 end-page: 1857 ident: bb0075 article-title: Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury publication-title: Kidney Int – volume: 69 start-page: 2131 year: 2006 end-page: 2147 ident: bb0250 article-title: The podocyte's response to injury: role in proteinuria and glomerulosclerosis publication-title: Kidney Int – volume: 292 start-page: F1657 year: 2007 end-page: F1661 ident: bb0275 article-title: Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator publication-title: Am J Physiol Renal Physiol – volume: 21 start-page: 1653 year: 2006 end-page: 1660 ident: bb0240 article-title: WT1 and glomerular diseases publication-title: Pediatr Nephrol – volume: 19 start-page: 217 year: 2008 end-page: 224 ident: bb0235 article-title: ATF3 protects against renal ischemia–reperfusion injury publication-title: J Am Soc Nephrol – volume: 105 start-page: 485 year: 2006 end-page: 491 ident: bb0025 article-title: Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery publication-title: Anesthesiology – volume: 29 start-page: 824 year: 1999 end-page: 826 ident: bb0110 article-title: Detection of WT1 mRNA in urine from patients with kidney diseases publication-title: Eur J Clin Invest – volume: 281 start-page: 18734 year: 2006 end-page: 18745 ident: bb0225 article-title: Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis publication-title: J Biol Chem – volume: 20 start-page: 105 year: 2005 end-page: 113 ident: bb0105 article-title: Messenger RNA expression of target genes in the urinary sediment of patients with chronic kidney diseases publication-title: Nephrol Dial Transplant – volume: 95 start-page: c91 year: 2003 end-page: c99 ident: bb0270 article-title: Urinary sediment podocalyxin in children with glomerular diseases publication-title: Nephron Clin Pract – volume: 5 start-page: 1760 year: 2006 end-page: 1771 ident: bb0125 article-title: Discovery of urinary biomarkers publication-title: Mol Cell Proteomics – volume: 272 start-page: F160 year: 1997 end-page: F166 ident: bb0145 article-title: Ischemia-induced receptor for activated C kinase (RACK1) expression in rat kidneys publication-title: Am J Physiol – volume: 272 start-page: 19943 year: 1997 end-page: 19950 ident: bb0185 article-title: Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney publication-title: J Biol Chem – volume: 69 start-page: 1302 year: 2006 end-page: 1307 ident: bb0280 article-title: The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease publication-title: Kidney Int – volume: 11 start-page: R31 year: 2007 ident: bb0310 article-title: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury publication-title: Crit Care – volume: 15 start-page: 1677 year: 2004 end-page: 1689 ident: bb0010 article-title: Discovery of protein biomarkers for renal diseases publication-title: J Am Soc Nephrol – volume: 63 start-page: 196 year: 2001 end-page: 207 ident: bb0140 article-title: Assessment of cisplatin-induced nephrotoxicity by microarray technology publication-title: Toxicol Sci – volume: 284 start-page: F218 year: 2003 end-page: F228 ident: bb0180 article-title: cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion publication-title: Am J Physiol Renal Physiol – volume: 45 start-page: 951 year: 2006 end-page: 957 ident: bb0295 article-title: Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis publication-title: Rheumatology (Oxford) – volume: 101 start-page: 13368 year: 2004 end-page: 13373 ident: bb0120 article-title: Identification and proteomic profiling of exosomes in human urine publication-title: Proc Natl Acad Sci USA – volume: 25 start-page: 375 year: 2006 end-page: 386 ident: bb0150 article-title: Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses publication-title: Physiol Genomics – volume: 21 start-page: 1534 year: 2006 end-page: 1540 ident: bb0300 article-title: The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis publication-title: Nephrol Dial Transplant – volume: 16 start-page: 3763 year: 2005 end-page: 3770 ident: bb0090 article-title: Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods publication-title: J Am Soc Nephrol – volume: 7 start-page: 321 year: 1999 end-page: 335 ident: bb0215 article-title: ATF3 and stress responses publication-title: Gene Expr – volume: 70 start-page: 199 year: 2006 end-page: 203 ident: bb0055 article-title: Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery publication-title: Kidney Int – volume: 441 start-page: 173 year: 2006 end-page: 178 ident: bb0220 article-title: Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 publication-title: Nature – volume: 24 start-page: 438 year: 2004 end-page: 447 ident: bb0190 article-title: Microarray analysis of focal segmental glomerulosclerosis publication-title: Am J Nephrol – volume: 62 start-page: 1601 year: 2002 end-page: 1610 ident: bb0060 article-title: Early detection of cysteine rich protein 61 (CYR61, CCN1) in urine following renal ischemic reperfusion injury publication-title: Kidney Int – volume: 366 start-page: 243 year: 2006 end-page: 248 ident: bb0095 article-title: Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease publication-title: Clin Chim Acta – volume: 290 start-page: F1187 year: 2006 end-page: F1193 ident: bb0070 article-title: Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury publication-title: Am J Physiol Renal Physiol – volume: 3 start-page: 439 year: 2007 end-page: 442 ident: bb0305 article-title: Improving outcomes of acute kidney injury: report of an initiative publication-title: Nat Clin Pract Nephrol – volume: 69 start-page: 399 year: 2006 end-page: 405 ident: bb0085 article-title: Glomerular filtration rate estimated by cystatin C among different clinical presentations publication-title: Kidney Int – volume: 12 start-page: 900 year: 2001 end-page: 908 ident: bb0230 article-title: Role of the increase in p21 in cisplatin-induced acute renal failure in rats publication-title: J Am Soc Nephrol – volume: 18 start-page: 515 year: 2007 end-page: 527 ident: bb0200 article-title: Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model publication-title: J Am Soc Nephrol – volume: 22 start-page: 295 year: 2007 end-page: 296 ident: bb0040 article-title: Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography publication-title: Nephrol Dial Transplant – volume: 12 start-page: 1883 year: 1997 end-page: 1889 ident: bb0100 article-title: Urinary and serum type III collagen: markers of renal fibrosis publication-title: Nephrol Dial Transplant – volume: 149 start-page: 237 year: 2007 end-page: 242 ident: bb0195 article-title: Transcriptional regulation of podocyte disease publication-title: Transl Res – volume: 26 start-page: 287 year: 2006 end-page: 292 ident: bb0045 article-title: Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions publication-title: Am J Nephrol – volume: 285 start-page: F40 year: 2003 end-page: F48 ident: bb0255 article-title: Urinary excretion of viable podocytes in health and renal disease publication-title: Am J Physiol Renal Physiol – volume: 2 start-page: 529 year: 2007 end-page: 542 ident: bb0205 article-title: A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases publication-title: Clin J Am Soc Nephrol – volume: 42 start-page: 497 year: 2003 end-page: 506 ident: bb0130 article-title: Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF publication-title: Am J Kidney Dis – volume: 24 start-page: 438 year: 2004 ident: 10.1038/ki.2008.206_bb0190 article-title: Microarray analysis of focal segmental glomerulosclerosis publication-title: Am J Nephrol doi: 10.1159/000080188 – volume: 353 start-page: 2342 year: 2005 ident: 10.1038/ki.2008.206_bb0285 article-title: Messenger RNA for FOXP3 in the urine of renal-allograft recipients publication-title: N Engl J Med doi: 10.1056/NEJMoa051907 – volume: 64 start-page: 480 year: 2003 ident: 10.1038/ki.2008.206_bb0160 article-title: Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog publication-title: Kidney Int doi: 10.1046/j.1523-1755.2003.00106.x – volume: 16 start-page: 408 year: 2005 ident: 10.1038/ki.2008.206_bb0115 article-title: Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2004070564 – volume: 16 start-page: 3763 year: 2005 ident: 10.1038/ki.2008.206_bb0090 article-title: Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005050512 – volume: 365 start-page: 1231 year: 2005 ident: 10.1038/ki.2008.206_bb0020 article-title: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery publication-title: Lancet doi: 10.1016/S0140-6736(05)74811-X – volume: 45 start-page: 951 year: 2006 ident: 10.1038/ki.2008.206_bb0295 article-title: Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/kel029 – volume: 25 start-page: 375 year: 2006 ident: 10.1038/ki.2008.206_bb0150 article-title: Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses publication-title: Physiol Genomics doi: 10.1152/physiolgenomics.00223.2005 – volume: 62 start-page: 1601 year: 2002 ident: 10.1038/ki.2008.206_bb0060 article-title: Early detection of cysteine rich protein 61 (CYR61, CCN1) in urine following renal ischemic reperfusion injury publication-title: Kidney Int doi: 10.1046/j.1523-1755.2002.00633.x – volume: 5 start-page: 1760 year: 2006 ident: 10.1038/ki.2008.206_bb0125 article-title: Discovery of urinary biomarkers publication-title: Mol Cell Proteomics doi: 10.1074/mcp.R600004-MCP200 – volume: 70 start-page: 1847 year: 2006 ident: 10.1038/ki.2008.206_bb0065 article-title: Biomarker and drug target discovery using proteomics in a new rat model of sepsis-induced acute renal failure publication-title: Kidney Int doi: 10.1038/sj.ki.5001575 – volume: 57 start-page: 208 year: 2002 ident: 10.1038/ki.2008.206_bb0175 article-title: Transcriptional regulation of podocyte specification and differentiation publication-title: Microsc Res Tech doi: 10.1002/jemt.10076 – year: 2007 ident: 10.1038/ki.2008.206_bb0080 article-title: Biomarkers for the early detection of acute kidney injury – volume: 69 start-page: 1471 year: 2006 ident: 10.1038/ki.2008.206_bb0135 article-title: Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery publication-title: Kidney Int doi: 10.1038/sj.ki.5000273 – volume: 105 start-page: 485 year: 2006 ident: 10.1038/ki.2008.206_bb0025 article-title: Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery publication-title: Anesthesiology doi: 10.1097/00000542-200609000-00011 – volume: 16 start-page: 3046 year: 2005 ident: 10.1038/ki.2008.206_bb0050 article-title: Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005030236 – volume: 272 start-page: 19943 year: 1997 ident: 10.1038/ki.2008.206_bb0185 article-title: Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney publication-title: J Biol Chem doi: 10.1074/jbc.272.32.19943 – volume: 70 start-page: 199 year: 2006 ident: 10.1038/ki.2008.206_bb0055 article-title: Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery publication-title: Kidney Int doi: 10.1038/sj.ki.5001527 – volume: 63 start-page: 196 year: 2001 ident: 10.1038/ki.2008.206_bb0140 article-title: Assessment of cisplatin-induced nephrotoxicity by microarray technology publication-title: Toxicol Sci doi: 10.1093/toxsci/63.2.196 – volume: 15 start-page: 1677 year: 2004 ident: 10.1038/ki.2008.206_bb0010 article-title: Discovery of protein biomarkers for renal diseases publication-title: J Am Soc Nephrol doi: 10.1097/01.ASN.0000129114.92265.32 – volume: 22 start-page: 295 year: 2007 ident: 10.1038/ki.2008.206_bb0040 article-title: Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfl408 – volume: 281 start-page: 18734 year: 2006 ident: 10.1038/ki.2008.206_bb0225 article-title: Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis publication-title: J Biol Chem doi: 10.1074/jbc.M511983200 – volume: 441 start-page: 173 year: 2006 ident: 10.1038/ki.2008.206_bb0220 article-title: Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 publication-title: Nature doi: 10.1038/nature04768 – volume: 11 start-page: R31 year: 2007 ident: 10.1038/ki.2008.206_bb0310 article-title: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury publication-title: Crit Care doi: 10.1186/cc5713 – volume: 112 start-page: 325 year: 2007 ident: 10.1038/ki.2008.206_bb0170 article-title: The podocyte in health and disease: insights from the mouse publication-title: Clin Sci (Lond) doi: 10.1042/CS20060143 – volume: 69 start-page: 1302 year: 2006 ident: 10.1038/ki.2008.206_bb0280 article-title: The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease publication-title: Kidney Int doi: 10.1038/sj.ki.5000221 – volume: 70 start-page: 1847 year: 2006 ident: 10.1038/ki.2008.206_bb0075 article-title: Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury publication-title: Kidney Int doi: 10.1038/sj.ki.5001874 – volume: 95 start-page: c91 year: 2003 ident: 10.1038/ki.2008.206_bb0270 article-title: Urinary sediment podocalyxin in children with glomerular diseases publication-title: Nephron Clin Pract doi: 10.1159/000074322 – volume: 20 start-page: 105 year: 2005 ident: 10.1038/ki.2008.206_bb0105 article-title: Messenger RNA expression of target genes in the urinary sediment of patients with chronic kidney diseases publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfh574 – volume: 19 start-page: 217 year: 2008 ident: 10.1038/ki.2008.206_bb0235 article-title: ATF3 protects against renal ischemia–reperfusion injury publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005111155 – volume: 272 start-page: F160 year: 1997 ident: 10.1038/ki.2008.206_bb0145 article-title: Ischemia-induced receptor for activated C kinase (RACK1) expression in rat kidneys publication-title: Am J Physiol – volume: 63 start-page: 1714 year: 2003 ident: 10.1038/ki.2008.206_bb0165 article-title: Differential gene expression following early renal ischemia/reperfusion publication-title: Kidney Int doi: 10.1046/j.1523-1755.2003.00928.x – volume: 12 start-page: 900 year: 2001 ident: 10.1038/ki.2008.206_bb0230 article-title: Role of the increase in p21 in cisplatin-induced acute renal failure in rats publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V125900 – volume: 292 start-page: F1657 year: 2007 ident: 10.1038/ki.2008.206_bb0275 article-title: Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00434.2006 – volume: 65 start-page: 6151 year: 2005 ident: 10.1038/ki.2008.206_bb0290 article-title: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2602 – volume: 18 start-page: 515 year: 2007 ident: 10.1038/ki.2008.206_bb0200 article-title: Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2006030217 – volume: 285 start-page: F40 year: 2003 ident: 10.1038/ki.2008.206_bb0255 article-title: Urinary excretion of viable podocytes in health and renal disease publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00404.2002 – volume: 80 start-page: 365 year: 2003 ident: 10.1038/ki.2008.206_bb0155 article-title: Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics publication-title: Mol Genet Metab doi: 10.1016/j.ymgme.2003.09.012 – volume: 61 start-page: 1646 year: 2002 ident: 10.1038/ki.2008.206_bb0210 article-title: Monitoring changes in gene expression in renal ischemia–reperfusion in the rat publication-title: Kidney Int doi: 10.1046/j.1523-1755.2002.00341.x – volume: 101 start-page: 13368 year: 2004 ident: 10.1038/ki.2008.206_bb0120 article-title: Identification and proteomic profiling of exosomes in human urine publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0403453101 – volume: 6 start-page: 1639 year: 2006 ident: 10.1038/ki.2008.206_bb0030 article-title: Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2006.01352.x – volume: 16 start-page: 1733 year: 2005 ident: 10.1038/ki.2008.206_bb0260 article-title: Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005020159 – volume: 21 start-page: 856 year: 2006 ident: 10.1038/ki.2008.206_bb0035 article-title: Kidney NGAL is a novel early marker of acute injury following transplantation publication-title: Pediatr Nephrol doi: 10.1007/s00467-006-0055-0 – volume: 5 start-page: 63 year: 2006 ident: 10.1038/ki.2008.206_bb0015 article-title: Acute kidney injury biomarkers-needs, present status, and future promise publication-title: NephSAP – volume: 290 start-page: F1187 year: 2006 ident: 10.1038/ki.2008.206_bb0070 article-title: Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00342.2005 – volume: 366 start-page: 243 year: 2006 ident: 10.1038/ki.2008.206_bb0095 article-title: Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease publication-title: Clin Chim Acta doi: 10.1016/j.cca.2005.10.007 – volume: 7 start-page: 321 year: 1999 ident: 10.1038/ki.2008.206_bb0215 article-title: ATF3 and stress responses publication-title: Gene Expr – volume: 284 start-page: F218 year: 2003 ident: 10.1038/ki.2008.206_bb0180 article-title: cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00054.2002 – volume: 286 start-page: F1116 year: 2004 ident: 10.1038/ki.2008.206_bb0315 article-title: A simplified method for HPLC determination of creatinine in mouse serum publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00366.2003 – volume: 69 start-page: 399 year: 2006 ident: 10.1038/ki.2008.206_bb0085 article-title: Glomerular filtration rate estimated by cystatin C among different clinical presentations publication-title: Kidney Int doi: 10.1038/sj.ki.5000073 – volume: 149 start-page: 237 year: 2007 ident: 10.1038/ki.2008.206_bb0195 article-title: Transcriptional regulation of podocyte disease publication-title: Transl Res doi: 10.1016/j.trsl.2007.01.002 – volume: 29 start-page: 824 year: 1999 ident: 10.1038/ki.2008.206_bb0110 article-title: Detection of WT1 mRNA in urine from patients with kidney diseases publication-title: Eur J Clin Invest doi: 10.1046/j.1365-2362.1999.00535.x – volume: 26 start-page: 287 year: 2006 ident: 10.1038/ki.2008.206_bb0045 article-title: Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions publication-title: Am J Nephrol doi: 10.1159/000093961 – volume: 106 start-page: c61 year: 2007 ident: 10.1038/ki.2008.206_bb0265 article-title: Podocyte damage resulting in podocyturia: a potential diagnostic marker to assess glomerular disease activity publication-title: Nephron Clin Pract doi: 10.1159/000101799 – volume: 21 start-page: 1653 year: 2006 ident: 10.1038/ki.2008.206_bb0240 article-title: WT1 and glomerular diseases publication-title: Pediatr Nephrol doi: 10.1007/s00467-006-0208-1 – volume: 69 start-page: 2131 year: 2006 ident: 10.1038/ki.2008.206_bb0250 article-title: The podocyte's response to injury: role in proteinuria and glomerulosclerosis publication-title: Kidney Int doi: 10.1038/sj.ki.5000410 – volume: 21 start-page: 1534 year: 2006 ident: 10.1038/ki.2008.206_bb0300 article-title: The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfk102 – volume: 72 start-page: 337 year: 2007 ident: 10.1038/ki.2008.206_bb0245 article-title: Early changes in gene expression that influence the course of primary glomerular disease publication-title: Kidney Int doi: 10.1038/sj.ki.5002302 – volume: 3 start-page: 439 year: 2007 ident: 10.1038/ki.2008.206_bb0305 article-title: Improving outcomes of acute kidney injury: report of an initiative publication-title: Nat Clin Pract Nephrol doi: 10.1038/ncpneph0551 – volume: 2 start-page: 529 year: 2007 ident: 10.1038/ki.2008.206_bb0205 article-title: A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.04121206 – volume: 42 start-page: 497 year: 2003 ident: 10.1038/ki.2008.206_bb0130 article-title: Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF publication-title: Am J Kidney Dis doi: 10.1016/S0272-6386(03)00744-3 – volume: 12 start-page: 1883 year: 1997 ident: 10.1038/ki.2008.206_bb0100 article-title: Urinary and serum type III collagen: markers of renal fibrosis publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/12.9.1883 |
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| Snippet | Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain... Urinary exosomes are excreted from all nephron segments and are a rich source of kidney injury biomarkers. Because exosomes contain intracellular proteins, we... |
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| SubjectTerms | Activating Transcription Factor 3 - urine Acute Kidney Injury - chemically induced Acute Kidney Injury - urine Adult Aged AKI Animals ATF3 Biological and medical sciences Biomarkers - urine Case-Control Studies Cisplatin - toxicity exosomes FSGS Gene Products, vpr - genetics Glomerulosclerosis, Focal Segmental - urine Humans Intracellular Signaling Peptides and Proteins - genetics Kidney - injuries Kidney Diseases - urine Male Medical sciences Membrane Proteins - genetics Mice Mice, Transgenic Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Podocytes - drug effects Podocytes - pathology Podocytes - physiology Rats Rats, Sprague-Dawley Renal failure Reperfusion Injury - urine transcription factor Transcription Factors - urine WT-1 WT1 Proteins - urine |
| Title | Urinary exosomal transcription factors, a new class of biomarkers for renal disease |
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