Radiation-Induced Liver Disease and Modern Radiotherapy
Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local co...
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| Published in | Seminars in radiation oncology Vol. 28; no. 4; pp. 321 - 331 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.10.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation-induced liver disease (RILD). Here, we will review the current understanding of classic and nonclassic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities. |
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| AbstractList | Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation-induced liver disease (RILD). Here, we will review the current understanding of classic and nonclassic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities.Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation-induced liver disease (RILD). Here, we will review the current understanding of classic and nonclassic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities. Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation-induced liver disease (RILD). Here, we will review the current understanding of classic and nonclassic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities. Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation induced liver disease (RILD). Here, we will review the current understanding of classic and non-classic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities. |
| Author | Koay, Eugene J. Das, Prajnan Owen, Dawn |
| AuthorAffiliation | 2 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| AuthorAffiliation_xml | – name: 2 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI – name: 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| Author_xml | – sequence: 1 givenname: Eugene J. surname: Koay fullname: Koay, Eugene J. organization: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX – sequence: 2 givenname: Dawn surname: Owen fullname: Owen, Dawn organization: † Department of Radiation Oncology, University of Michigan, Ann Arbor, MI – sequence: 3 givenname: Prajnan surname: Das fullname: Das, Prajnan email: prajdas@mdanderson.org organization: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30309642$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2307/3577586 10.1016/j.ijrobp.2004.05.048 10.1016/j.mri.2014.02.019 10.1016/j.semradonc.2011.05.003 10.1016/j.semradonc.2005.04.005 10.1016/j.mehy.2014.08.004 10.1088/0031-9155/61/17/6465 10.1200/JCO.2015.64.2710 10.1016/0002-9610(92)90400-L 10.1016/j.ijrobp.2007.05.078 10.1016/j.ijrobp.2011.10.020 10.1002/hep.1840140614 10.1002/hep.510260117 10.1016/j.ijrobp.2007.04.005 10.1002/hep.29232 10.1016/j.ijrobp.2009.06.092 10.1200/JCO.2005.05.3074 10.1016/j.ijrobp.2008.10.073 10.1053/srao.2001.23485 10.1002/lt.21805 10.2217/pme.10.5 10.1016/S0168-8278(99)80018-X 10.1016/S0167-8140(02)00061-0 10.1182/blood.V89.5.1501 10.1016/j.ijrobp.2012.02.037 10.1016/j.radonc.2015.04.011 10.1158/1078-0432.CCR-06-2459 10.1200/JCO.2012.48.5896 10.1016/j.prro.2016.10.003 10.1007/s10620-005-1596-y 10.1371/journal.pone.0181488 10.1097/MNM.0000000000000695 10.1016/j.jhep.2012.01.031 10.1016/0090-8258(86)90316-1 10.1016/j.gie.2013.07.023 10.1016/0360-3016(91)90171-Y 10.1016/j.jhep.2016.05.045 10.1007/s00261-016-0753-4 10.1155/2013/815105 10.1016/j.meddos.2017.01.005 10.1002/hep.1840220415 10.1016/0360-3016(92)90651-W 10.1002/hep.26947 10.1016/j.ijrobp.2005.01.002 10.1016/j.semradonc.2017.02.004 10.1016/0360-3016(81)90370-9 10.1200/JCO.2008.19.6329 10.1016/j.semradonc.2011.05.006 10.1136/gutjnl-2011-301348 10.21037/jgo.2017.03.14 10.1097/01.sla.0000251747.80025.b7 10.1200/JCO.2007.14.3529 10.1200/JCO.2015.61.3778 10.1200/JCO.2014.57.9151 10.1016/j.ijrobp.2013.10.045 10.1200/JCO.1998.16.6.2246 10.1002/hep.1840040109 10.1016/0360-3016(93)90428-X 10.1016/j.prro.2017.03.004 10.1016/j.ijrobp.2016.06.1041 10.1080/02841860600897934 10.7759/cureus.1674 10.1016/j.ijrobp.2005.12.031 10.1016/j.ijrobp.2015.09.044 10.1371/journal.pone.0112731 10.1200/JCO.2005.00.620 10.1016/j.accpm.2015.06.006 10.1111/j.1399-0012.2010.01252.x 10.1016/j.mri.2015.06.013 10.1016/S0360-3016(02)02846-8 10.1093/jrr/rrw008 10.1080/02841860600936369 10.1056/NEJMra1504367 10.1097/MD.0000000000002877 10.1186/1748-717X-6-40 10.1016/j.ijrobp.2017.01.221 10.4254/wjh.v8.i7.355 10.1200/JCO.2012.44.1659 10.1016/j.ijrobp.2017.09.032 10.1016/j.prro.2015.02.007 10.1002/hep.21051 10.1016/j.ijrobp.2014.11.028 10.1056/NEJMoa0801209 10.1016/j.jamcollsurg.2005.01.024 10.1080/02841860600904870 10.1016/j.jhep.2008.03.009 10.1016/S0360-3016(96)00587-1 10.1016/j.semradonc.2017.04.002 10.1002/cncr.29878 10.1111/j.1478-3231.2012.02784.x 10.1111/1754-9485.12393 10.1007/s00270-014-0872-7 10.1186/s13550-016-0212-9 10.1016/j.meddos.2007.04.008 10.1016/j.ijrobp.2010.07.015 10.1016/j.radonc.2016.10.024 10.1016/j.hpb.2015.07.007 10.1118/1.4766877 10.1200/JCO.2006.08.1828 10.1001/jamaoncol.2017.2303 10.3109/0284186X.2011.590526 10.1016/j.clinimag.2016.03.003 10.1002/hep.21563 |
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| Copyright | 2018 Elsevier Inc. Copyright © 2018 Elsevier Inc. All rights reserved. |
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| References | Mendez Romero, Wunderink, Hussain (bib0052) 2006; 45 Chapman, Kumarapeli, Nyflot (bib0057) 2015; 6 Dawson, Ten Haken (bib0090) 2005; 15 Krag, Wiest, Albillos (bib0031) 2012; 61 Kamath, Kim, Advanced Liver Disease Study (bib0041) 2007; 45 Cao, Wang, Johnson (bib0072) 2013; 85 Plevris, Jalan, Bzeizi (bib0067) 1999; 30 McCormack, Petrowsky, Jochum (bib0026) 2007; 245 Kudithipudi, Day, Thai (bib0050) 2016; 96 Bujold, Massey, Kim (bib0009) 2013; 31 Yoon, Koom, Lee (bib0070) 2012; 32 Levesque, Saliba, Benhamida (bib0063) 2009; 15 Asayama, Nishie, Ishigami (bib0078) 2016; 41 Rimola, Soto, Bory (bib0047) 1984; 4 Garlipp, de Baere, Damm (bib0096) 2014; 59 Lamesch, Ringe, Oellerich (bib0065) 1990; 22 Dawson, Eccles, Craig (bib0008) 2006; 45 Oellerich, Burdelski, Lautz (bib0066) 1991; 14 Toesca, Osmundson, Eyben (bib0093) 2017; 122 Richter, Seco, Hong (bib0077) 2014; 83 Wang, Feng, Jackson (bib0088) 2016; 94 Seidensticker, Seidensticker, Mohnike (bib0084) 2011; 6 Bearman, Lee, Baron (bib0108) 1997; 89 Mizumoto M, Okumura T, Hashimoto T. Proton beam therapy for hepatocellular carcinoma: A comparison of three treatment protocols. Int J Radiat Oncol Biol Phys 81:1039-1045, 2011 Tse, Hawkins, Lockwood (bib0007) 2008; 26 Liang, Zhu, Xu (bib0020) 2006; 65 Schefter, Kavanagh, Timmerman (bib0105) 2005; 62 Besa, Bane, Jajamovich (bib0075) 2015; 33 Borgelt, Gelber, Brady (bib0003) 1981; 7 Hemming, Scudamore, Shackleton (bib0064) 1992; 163 Kawashima, Furuse, Nishio (bib0013) 2005; 23 Osmundson, Wu, Luxton (bib0094) 2015; 91 Kavanagh, Schefter, Cardenes (bib0104) 2006; 45 (bib0037) 2016; 65 Barry, McPartlin, Lindsay (bib0106) 2017; 7 Peng, Qi, Guo (bib0038) 2016; 95 Levesque, Martin, Dudau (bib0061) 2016; 35 Cheng, Wu, Lee (bib0019) 2004; 60 Yuan, Chen, Qian (bib0036) 2016; 2016 Apisarnthanarax S, Saini J, O'Ryan-Blair A: Intensity modulated proton therapy with advanced planning techniques in a challenging hepatocellular carcinoma patient. Cureus 9:e1674, 2017 Seidensticker, Burak, Kalinski (bib0085) 2015; 38 Gayou, Day, Mohammadi (bib0049) 2012; 39 Reed, Cox (bib0002) 1966; 48 Feng, Suresh, Schipper (bib0074) 2017; 4 Ohara, Okumura, Tsuji (bib0095) 1997; 38 Wang, Krishnan, Zhang (bib0010) 2008; 33 Bowen, Saini, Chapman (bib0059) 2015; 115 Chou, Chen, Lee (bib0024) 2007; 13 Wu, Epelman, Wang (bib0087) 2016; 61 Zamor, deLemos, Russo (bib0034) 2017; 8 Velec, Haddad, Craig (bib0107) 2017; 97 Anscher, Crocker, Jirtle (bib0022) 1990; 122 Hwang, Shergill, Acosta (bib0033) 2014; 80 Toesca, Osmundson, von Eyben (bib0044) 2017; 7 Tao EA. Ablative radiotherapy doses lead to a substantial prolongation of survival in patients with inoperable intrahepatic cholangiocarcinoma. J Clin Oncol 34:219-226, 2015 Vauthey, Pawlik, Ribero (bib0027) 2006; 24 Bowen, Chapman, Borgman (bib0056) 2016; 6 Russell, Clyde, Wasserman (bib0004) 1993; 27 Fukumitsu, Sugahara, Nakayama (bib0012) 2009; 74 Gentilucci, Santini, Vincenzi (bib0028) 2006; 24 Crane, Koay (bib0017) 2016; 122 Emami, Lyman, Brown (bib0091) 1991; 21 Ingold, Reed, Kaplan (bib0089) 1965; 93 Petersen, Lassen, Hansen (bib0011) 2011; 50 Okamoto, Nishie, Asayama (bib0080) 2014; 32 Levesque, Hoti, Azoulay (bib0062) 2011; 25 Seidensticker, Seidensticker, Damm (bib0111) 2014; 9 Dawson, Normolle, Balter (bib0006) 2002; 53 Case (bib0001) 1924; 12 McGinn, Ten Haken, Ensminger (bib0005) 1998; 16 Johnson, Berhane, Kagebayashi (bib0043) 2015; 33 Goebel, Sulke, Lazik-Palm (bib0097) 2017; 12 Hoefs, Sheikh, Guerrero (bib0048) 2005; 50 Munoz-Schuffenegger, Ng, Dawson (bib0099) 2017; 27 Ge, Runyon (bib0030) 2016; 375 De Gasperi, Mazza, Prosperi (bib0060) 2016; 8 Cao, Pan, Balter (bib0071) 2008; 70 Cheng, Wu, Huang (bib0018) 2002; 63 Fernandez, Ritter, Goodwin (bib0029) 2005; 200 Lawrence, Ten Haken, Kessler (bib0021) 1992; 23 Yeo, Johnson (bib0101) 2006; 43 Lasley, Mannina, Johnson (bib0053) 2015; 5 Suresh, Owen, Bazzi (bib0069) 2017; 100 Tsegmed, Kimura, Nakashima (bib0086) 2017; 42 Sanuki, Takeda, Oku (bib0082) 2014; 88 Schacter, Crum, Spitzer (bib0054) 1986; 24 Friedman (bib0032) 2016 Yin, Li, Han (bib0035) 2013; 31 Pan, Kavanagh, Dawson (bib0039) 2010; 76 Chang, Huang, Liu (bib0079) 2016; 40 Afdhal, McHutchison, Brown (bib0045) 2008; 48 Maor, Malnick (bib0025) 2013; 2013 Kirichenko, Gayou, Parda (bib0051) 2016; 18 Schefter, Kavanagh (bib0103) 2011; 21 Rusthoven, Kavanagh, Cardenes (bib0092) 2009; 27 Kim, Biggins, Kremers (bib0042) 2008; 359 Kokudo, Hasegawa, Kokudo (bib0068) 2017; 66 Goodman, Kavanagh (bib0102) 2017; 27 Hoefs, Wang, Kanel (bib0046) 1995; 22 Guha, Kavanagh (bib0040) 2011; 21 Dawson, Ten Haken, Lawrence (bib0098) 2001; 11 Hong, Wo, Yeap (bib0015) 2016; 34 Van Beers, Pastor, Hussain (bib0076) 2012; 57 Sempoux, Horsmans, Geubel (bib0023) 1997; 26 Jung, Yoon, Cho (bib0081) 2016; 60 Kim, Park, Kim (bib0100) 2007; 69 Normolle, Pan (bib0073) 2010; 7 Richardson, Elias, Krishnan (bib0109) 1998; 92 Matesan, Bowen, Chapman (bib0055) 2017; 38 Feng, Smith, Normolle (bib0110) 2012; 83 Doi, Shiomi, Masai (bib0083) 2016; 57 Wang (10.1016/j.semradonc.2018.06.007_bib0010) 2008; 33 De Gasperi (10.1016/j.semradonc.2018.06.007_bib0060) 2016; 8 Ingold (10.1016/j.semradonc.2018.06.007_bib0089) 1965; 93 Afdhal (10.1016/j.semradonc.2018.06.007_bib0045) 2008; 48 Levesque (10.1016/j.semradonc.2018.06.007_bib0063) 2009; 15 Gayou (10.1016/j.semradonc.2018.06.007_bib0049) 2012; 39 Levesque (10.1016/j.semradonc.2018.06.007_bib0061) 2016; 35 10.1016/j.semradonc.2018.06.007_bib0016 Kamath (10.1016/j.semradonc.2018.06.007_bib0041) 2007; 45 Schacter (10.1016/j.semradonc.2018.06.007_bib0054) 1986; 24 Kudithipudi (10.1016/j.semradonc.2018.06.007_bib0050) 2016; 96 10.1016/j.semradonc.2018.06.007_bib0014 Wu (10.1016/j.semradonc.2018.06.007_bib0087) 2016; 61 Lamesch (10.1016/j.semradonc.2018.06.007_bib0065) 1990; 22 Garlipp (10.1016/j.semradonc.2018.06.007_bib0096) 2014; 59 Dawson (10.1016/j.semradonc.2018.06.007_bib0008) 2006; 45 Pan (10.1016/j.semradonc.2018.06.007_bib0039) 2010; 76 Feng (10.1016/j.semradonc.2018.06.007_bib0074) 2017; 4 Okamoto (10.1016/j.semradonc.2018.06.007_bib0080) 2014; 32 Yin (10.1016/j.semradonc.2018.06.007_bib0035) 2013; 31 Liang (10.1016/j.semradonc.2018.06.007_bib0020) 2006; 65 Crane (10.1016/j.semradonc.2018.06.007_bib0017) 2016; 122 Bearman (10.1016/j.semradonc.2018.06.007_bib0108) 1997; 89 Osmundson (10.1016/j.semradonc.2018.06.007_bib0094) 2015; 91 Schefter (10.1016/j.semradonc.2018.06.007_bib0103) 2011; 21 Kavanagh (10.1016/j.semradonc.2018.06.007_bib0104) 2006; 45 Kawashima (10.1016/j.semradonc.2018.06.007_bib0013) 2005; 23 Hemming (10.1016/j.semradonc.2018.06.007_bib0064) 1992; 163 Tsegmed (10.1016/j.semradonc.2018.06.007_bib0086) 2017; 42 Fernandez (10.1016/j.semradonc.2018.06.007_bib0029) 2005; 200 Lasley (10.1016/j.semradonc.2018.06.007_bib0053) 2015; 5 Jung (10.1016/j.semradonc.2018.06.007_bib0081) 2016; 60 Besa (10.1016/j.semradonc.2018.06.007_bib0075) 2015; 33 Kim (10.1016/j.semradonc.2018.06.007_bib0100) 2007; 69 Sempoux (10.1016/j.semradonc.2018.06.007_bib0023) 1997; 26 McGinn (10.1016/j.semradonc.2018.06.007_bib0005) 1998; 16 Gentilucci (10.1016/j.semradonc.2018.06.007_bib0028) 2006; 24 Lawrence (10.1016/j.semradonc.2018.06.007_bib0021) 1992; 23 Cheng (10.1016/j.semradonc.2018.06.007_bib0019) 2004; 60 Zamor (10.1016/j.semradonc.2018.06.007_bib0034) 2017; 8 Johnson (10.1016/j.semradonc.2018.06.007_bib0043) 2015; 33 Feng (10.1016/j.semradonc.2018.06.007_bib0110) 2012; 83 Cao (10.1016/j.semradonc.2018.06.007_bib0072) 2013; 85 Seidensticker (10.1016/j.semradonc.2018.06.007_bib0085) 2015; 38 Wang (10.1016/j.semradonc.2018.06.007_bib0088) 2016; 94 Toesca (10.1016/j.semradonc.2018.06.007_bib0093) 2017; 122 Seidensticker (10.1016/j.semradonc.2018.06.007_bib0084) 2011; 6 Goebel (10.1016/j.semradonc.2018.06.007_bib0097) 2017; 12 Yuan (10.1016/j.semradonc.2018.06.007_bib0036) 2016; 2016 Schefter (10.1016/j.semradonc.2018.06.007_bib0105) 2005; 62 Dawson (10.1016/j.semradonc.2018.06.007_bib0006) 2002; 53 Hwang (10.1016/j.semradonc.2018.06.007_bib0033) 2014; 80 Hoefs (10.1016/j.semradonc.2018.06.007_bib0046) 1995; 22 Goodman (10.1016/j.semradonc.2018.06.007_bib0102) 2017; 27 McCormack (10.1016/j.semradonc.2018.06.007_bib0026) 2007; 245 Ge (10.1016/j.semradonc.2018.06.007_bib0030) 2016; 375 Plevris (10.1016/j.semradonc.2018.06.007_bib0067) 1999; 30 Richardson (10.1016/j.semradonc.2018.06.007_bib0109) 1998; 92 (10.1016/j.semradonc.2018.06.007_bib0037) 2016; 65 Bowen (10.1016/j.semradonc.2018.06.007_bib0056) 2016; 6 Munoz-Schuffenegger (10.1016/j.semradonc.2018.06.007_bib0099) 2017; 27 Dawson (10.1016/j.semradonc.2018.06.007_bib0090) 2005; 15 Anscher (10.1016/j.semradonc.2018.06.007_bib0022) 1990; 122 Ohara (10.1016/j.semradonc.2018.06.007_bib0095) 1997; 38 Richter (10.1016/j.semradonc.2018.06.007_bib0077) 2014; 83 Van Beers (10.1016/j.semradonc.2018.06.007_bib0076) 2012; 57 Bujold (10.1016/j.semradonc.2018.06.007_bib0009) 2013; 31 Russell (10.1016/j.semradonc.2018.06.007_bib0004) 1993; 27 10.1016/j.semradonc.2018.06.007_bib0058 Tse (10.1016/j.semradonc.2018.06.007_bib0007) 2008; 26 Peng (10.1016/j.semradonc.2018.06.007_bib0038) 2016; 95 Rimola (10.1016/j.semradonc.2018.06.007_bib0047) 1984; 4 Hoefs (10.1016/j.semradonc.2018.06.007_bib0048) 2005; 50 Matesan (10.1016/j.semradonc.2018.06.007_bib0055) 2017; 38 Cheng (10.1016/j.semradonc.2018.06.007_bib0018) 2002; 63 Reed (10.1016/j.semradonc.2018.06.007_bib0002) 1966; 48 Suresh (10.1016/j.semradonc.2018.06.007_bib0069) 2017; 100 Borgelt (10.1016/j.semradonc.2018.06.007_bib0003) 1981; 7 Asayama (10.1016/j.semradonc.2018.06.007_bib0078) 2016; 41 Yeo (10.1016/j.semradonc.2018.06.007_bib0101) 2006; 43 Doi (10.1016/j.semradonc.2018.06.007_bib0083) 2016; 57 Dawson (10.1016/j.semradonc.2018.06.007_bib0098) 2001; 11 Friedman (10.1016/j.semradonc.2018.06.007_bib0032) 2016 Kim (10.1016/j.semradonc.2018.06.007_bib0042) 2008; 359 Levesque (10.1016/j.semradonc.2018.06.007_bib0062) 2011; 25 Kokudo (10.1016/j.semradonc.2018.06.007_bib0068) 2017; 66 Velec (10.1016/j.semradonc.2018.06.007_bib0107) 2017; 97 Maor (10.1016/j.semradonc.2018.06.007_bib0025) 2013; 2013 Toesca (10.1016/j.semradonc.2018.06.007_bib0044) 2017; 7 Kirichenko (10.1016/j.semradonc.2018.06.007_bib0051) 2016; 18 Chang (10.1016/j.semradonc.2018.06.007_bib0079) 2016; 40 Mendez Romero (10.1016/j.semradonc.2018.06.007_bib0052) 2006; 45 Chapman (10.1016/j.semradonc.2018.06.007_bib0057) 2015; 6 Oellerich (10.1016/j.semradonc.2018.06.007_bib0066) 1991; 14 Cao (10.1016/j.semradonc.2018.06.007_bib0071) 2008; 70 Rusthoven (10.1016/j.semradonc.2018.06.007_bib0092) 2009; 27 Chou (10.1016/j.semradonc.2018.06.007_bib0024) 2007; 13 Sanuki (10.1016/j.semradonc.2018.06.007_bib0082) 2014; 88 Krag (10.1016/j.semradonc.2018.06.007_bib0031) 2012; 61 Guha (10.1016/j.semradonc.2018.06.007_bib0040) 2011; 21 Petersen (10.1016/j.semradonc.2018.06.007_bib0011) 2011; 50 Bowen (10.1016/j.semradonc.2018.06.007_bib0059) 2015; 115 Hong (10.1016/j.semradonc.2018.06.007_bib0015) 2016; 34 Seidensticker (10.1016/j.semradonc.2018.06.007_bib0111) 2014; 9 Barry (10.1016/j.semradonc.2018.06.007_bib0106) 2017; 7 Normolle (10.1016/j.semradonc.2018.06.007_bib0073) 2010; 7 Case (10.1016/j.semradonc.2018.06.007_bib0001) 1924; 12 Fukumitsu (10.1016/j.semradonc.2018.06.007_bib0012) 2009; 74 Yoon (10.1016/j.semradonc.2018.06.007_bib0070) 2012; 32 Emami (10.1016/j.semradonc.2018.06.007_bib0091) 1991; 21 Vauthey (10.1016/j.semradonc.2018.06.007_bib0027) 2006; 24 |
| References_xml | – volume: 61 start-page: 6465 year: 2016 end-page: 6484 ident: bib0087 article-title: Optimizing global liver function in radiation therapy treatment planning publication-title: Phys Med Biol – volume: 60 start-page: 96 year: 2016 end-page: 101 ident: bib0081 article-title: Hepatic reaction dose for parenchymal changes on Gd-EOB-DTPA-enhanced magnetic resonance images after stereotactic body radiation therapy for hepatocellular carcinoma publication-title: J Med Imaging Radiat Oncol – volume: 45 start-page: 848 year: 2006 end-page: 855 ident: bib0104 article-title: Interim analysis of a prospective phase I/II trial of SBRT for liver metastases publication-title: Acta Oncol – volume: 97 start-page: 939 year: 2017 end-page: 946 ident: bib0107 article-title: Predictors of liver toxicity following stereotactic body radiation therapy for hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys – volume: 96 start-page: E179 year: 2016 end-page: E180 ident: bib0050 article-title: Hepatic failure progression is not hastened in intermediate-risk hepatocellular carcinoma after stereotactic radiation therapy (SRT) with functional treatment planning publication-title: Int J Radiat Oncol Biol Phys – volume: 43 start-page: 209 year: 2006 end-page: 220 ident: bib0101 article-title: Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy publication-title: Hepatology – volume: 8 start-page: 229 year: 2017 end-page: 242 ident: bib0034 article-title: Viral hepatitis and hepatocellular carcinoma: Etiology and management publication-title: J Gastrointest Oncol – volume: 38 start-page: 213 year: 2015 end-page: 221 ident: bib0085 article-title: Radiation-induced liver damage: Correlation of histopathology with hepatobiliary magnetic resonance imaging, a feasibility study publication-title: Cardiovasc Interventional Radiol – volume: 23 start-page: 781 year: 1992 end-page: 788 ident: bib0021 article-title: The use of 3-D dose volume analysis to predict radiation hepatitis publication-title: Int J Radiat Oncol Biol Phys – volume: 11 start-page: 240 year: 2001 end-page: 246 ident: bib0098 article-title: Partial irradiation of the liver publication-title: Semin Radiat Oncol – volume: 4 start-page: 53 year: 1984 end-page: 58 ident: bib0047 article-title: Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis publication-title: Hepatology – volume: 15 start-page: 1358 year: 2009 end-page: 1364 ident: bib0063 article-title: Plasma disappearance rate of indocyanine green: A tool to evaluate early graft outcome after liver transplantation publication-title: Liver Transpl – volume: 122 start-page: 1974 year: 2016 end-page: 1986 ident: bib0017 article-title: Solutions that enable ablative radiotherapy for large liver tumors: Fractionated dose painting, simultaneous integrated protection, motion management, and computed tomography image guidance publication-title: Cancer – volume: 23 start-page: 1839 year: 2005 end-page: 1846 ident: bib0013 article-title: Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma publication-title: J Clin Oncol – volume: 95 start-page: e2877 year: 2016 ident: bib0038 article-title: Child-Pugh versus MELD score for the assessment of prognosis in liver cirrhosis: A systematic review and meta-analysis of observational studies publication-title: Medicine (Baltimore) – volume: 88 start-page: 306 year: 2014 end-page: 311 ident: bib0082 article-title: Threshold doses for focal liver reaction after stereotactic ablative body radiation therapy for small hepatocellular carcinoma depend on liver function: Evaluation on magnetic resonance imaging with Gd-EOB-DTPA publication-title: Int J Radiat Oncol Biol Phys – volume: 12 start-page: e0181488 year: 2017 ident: bib0097 article-title: Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma publication-title: PLoS One – volume: 24 start-page: 373 year: 1986 end-page: 380 ident: bib0054 article-title: Fatal radiation hepatitis: A case report and review of the literature publication-title: Gynecol Oncol – volume: 31 start-page: 3647 year: 2013 end-page: 3655 ident: bib0035 article-title: Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma: A two-stage longitudinal clinical study publication-title: J Clin Oncol – volume: 76 start-page: S94 year: 2010 end-page: 100 ident: bib0039 article-title: Radiation-associated liver injury publication-title: Int J Radiat Oncol Biol Phys – volume: 91 start-page: 986 year: 2015 end-page: 994 ident: bib0094 article-title: Predictors of toxicity associated with stereotactic body radiation therapy to the central hepatobiliary tract publication-title: Int J Radiat Oncol Biol Phys – volume: 26 start-page: 128 year: 1997 end-page: 134 ident: bib0023 article-title: Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: Activation of hepatic stellate cells as an early event publication-title: Hepatology – reference: Apisarnthanarax S, Saini J, O'Ryan-Blair A: Intensity modulated proton therapy with advanced planning techniques in a challenging hepatocellular carcinoma patient. Cureus 9:e1674, 2017 – volume: 33 start-page: 1075 year: 2015 end-page: 1082 ident: bib0075 article-title: 3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function publication-title: Magn Reson Imaging – volume: 163 start-page: 515 year: 1992 end-page: 518 ident: bib0064 article-title: Indocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients publication-title: Am J Surg – volume: 375 start-page: 767 year: 2016 end-page: 777 ident: bib0030 article-title: Treatment of patients with cirrhosis publication-title: N Engl J Med – volume: 48 start-page: 1000 year: 2008 end-page: 1007 ident: bib0045 article-title: Thrombocytopenia associated with chronic liver disease publication-title: J Hepatol – volume: 24 start-page: 2065 year: 2006 end-page: 2072 ident: bib0027 article-title: Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases publication-title: J Clin Oncol – volume: 16 start-page: 2246 year: 1998 end-page: 2252 ident: bib0005 article-title: Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model publication-title: J Clin Oncol – volume: 7 start-page: e331 year: 2017 end-page: e337 ident: bib0106 article-title: Dosimetric analysis of liver toxicity after liver metastasis stereotactic body radiation therapy publication-title: Pract Radiat Oncol – reference: Mizumoto M, Okumura T, Hashimoto T. Proton beam therapy for hepatocellular carcinoma: A comparison of three treatment protocols. Int J Radiat Oncol Biol Phys 81:1039-1045, 2011 – volume: 50 start-page: 823 year: 2011 end-page: 828 ident: bib0011 article-title: Normal liver tissue sparing by intensity-modulated proton stereotactic body radiotherapy for solitary liver tumours publication-title: Acta Oncol – volume: 245 start-page: 923 year: 2007 end-page: 930 ident: bib0026 article-title: Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: A matched case-control study publication-title: Ann Surg – volume: 12 start-page: 27 year: 1924 ident: bib0001 article-title: The occurrence of hepatic lesions in patients treated by intensive deep roentgen irradiation publication-title: Am J Roentgenol Radium Ther Nucl Med – volume: 34 start-page: 460 year: 2016 end-page: 468 ident: bib0015 article-title: Multi-Institutional Phase II study of high-dose hypofractionated proton beam therapy in patients with localized, unresectable hepatocellular carcinoma and intrahepatic cholangiocarcinoma publication-title: J Clin Oncol – volume: 65 start-page: 734 year: 2016 end-page: 740 ident: bib0037 article-title: Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: Data from three ANRS cohorts publication-title: J Hepatol – volume: 21 start-page: 264 year: 2011 end-page: 270 ident: bib0103 article-title: Radiation therapy for liver metastases publication-title: Semin Radiat Oncol – volume: 48 start-page: 597 year: 1966 end-page: 611 ident: bib0002 article-title: The human liver after radiation injury. A form of veno-occlusive disease publication-title: Am J Pathol – volume: 6 start-page: 57 year: 2016 ident: bib0056 article-title: Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients publication-title: EJNMMI Res – volume: 18 start-page: 88 year: 2016 end-page: 97 ident: bib0051 article-title: Stereotactic body radiotherapy (SBRT) with or without surgery for primary and metastatic liver tumors publication-title: HPB (Oxford) – volume: 13 start-page: 851 year: 2007 end-page: 857 ident: bib0024 article-title: Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells publication-title: Clin Cancer Res – volume: 38 start-page: 577 year: 2017 end-page: 586 ident: bib0055 article-title: Assessment of functional liver reserve: Old and new in 99mTc-sulfur colloid scintigraphy publication-title: Nucl Med Commun – volume: 61 start-page: 967 year: 2012 end-page: 969 ident: bib0031 article-title: The window hypothesis: Haemodynamic and non-haemodynamic effects of beta-blockers improve survival of patients with cirrhosis during a window in the disease publication-title: Gut – volume: 30 start-page: 142 year: 1999 end-page: 148 ident: bib0067 article-title: Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function publication-title: J Hepatol – volume: 27 start-page: 1572 year: 2009 end-page: 1578 ident: bib0092 article-title: Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases publication-title: J Clin Oncol – volume: 27 start-page: 117 year: 1993 end-page: 123 ident: bib0004 article-title: Accelerated hyperfractionated hepatic irradiation in the management of patients with liver metastases: Results of the RTOG dose escalating protocol publication-title: Int J Radiat Oncol Biol Phys – volume: 60 start-page: 1502 year: 2004 end-page: 1509 ident: bib0019 article-title: Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease publication-title: Int J Radiat Oncol Biol Phys – volume: 359 start-page: 1018 year: 2008 end-page: 1026 ident: bib0042 article-title: Hyponatremia and mortality among patients on the liver-transplant waiting list publication-title: N Engl J Med – volume: 25 start-page: 297 year: 2011 end-page: 301 ident: bib0062 article-title: Non-invasive ICG-clearance: A useful tool for the management of hepatic artery thrombosis following liver transplantation publication-title: Clin Transplant – volume: 62 start-page: 1371 year: 2005 end-page: 1378 ident: bib0105 article-title: A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases publication-title: Int J Radiat Oncol Biol Phys – start-page: 663 year: 2016 end-page: 720 ident: bib0032 article-title: Current Medical Diagnosis & Treatment – volume: 100 start-page: 131 year: 2017 end-page: 137 ident: bib0069 article-title: Using Indocyanine Green extraction to predict liver function after stereotactic body radiation therapy for hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys – volume: 74 start-page: 831 year: 2009 end-page: 836 ident: bib0012 article-title: A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys – volume: 65 start-page: 426 year: 2006 end-page: 434 ident: bib0020 article-title: Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance publication-title: Int J Radiat Oncol Biol Phys – volume: 45 start-page: 856 year: 2006 end-page: 864 ident: bib0008 article-title: Individualized image guided iso-NTCP based liver cancer SBRT publication-title: Acta Oncol – volume: 4 start-page: 40 year: 2017 end-page: 47 ident: bib0074 article-title: Individualized adaptive stereotactic body radiotherapy for liver tumors in patients at high risk for liver damage: A phase 2 clinical trial publication-title: JAMA Oncol – volume: 39 start-page: 7398 year: 2012 end-page: 7401 ident: bib0049 article-title: A method for registration of single photon emission computed tomography (SPECT) and computed tomography (CT) images for liver stereotactic radiotherapy (SRT) publication-title: Med Phys – volume: 94 start-page: 181 year: 2016 end-page: 188 ident: bib0088 article-title: Local and global function model of the liver publication-title: Int J Radiat Oncol Biol Phys – volume: 22 start-page: 1113 year: 1995 end-page: 1121 ident: bib0046 article-title: The liver-spleen scan as a quantitative liver function test: Correlation with liver severity at peritoneoscopy publication-title: Hepatology – volume: 38 start-page: 367 year: 1997 end-page: 372 ident: bib0095 article-title: Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: Analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy publication-title: Int J Radiat Oncol Biol Phys – volume: 33 start-page: 550 year: 2015 end-page: 558 ident: bib0043 article-title: Assessment of liver function in patients with hepatocellular carcinoma: A new evidence-based approach-the ALBI grade publication-title: J Clin Oncol – reference: Tao EA. Ablative radiotherapy doses lead to a substantial prolongation of survival in patients with inoperable intrahepatic cholangiocarcinoma. J Clin Oncol 34:219-226, 2015 – volume: 35 start-page: 49 year: 2016 end-page: 57 ident: bib0061 article-title: Current use and perspective of indocyanine green clearance in liver diseases publication-title: Anaesth Crit Care Pain Med – volume: 5 start-page: e443 year: 2015 end-page: e449 ident: bib0053 article-title: Treatment variables related to liver toxicity in patients with hepatocellular carcinoma, Child-Pugh class A and B enrolled in a phase 1-2 trial of stereotactic body radiation therapy publication-title: Pract Radiat Oncol – volume: 31 start-page: 1631 year: 2013 end-page: 1639 ident: bib0009 article-title: Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma publication-title: J Clin Oncol – volume: 200 start-page: 845 year: 2005 end-page: 853 ident: bib0029 article-title: Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases publication-title: J Am Coll Surg – volume: 92 start-page: 737 year: 1998 end-page: 744 ident: bib0109 article-title: Treatment of severe veno-occlusive disease with defibrotide: Compassionate use results in response without significant toxicity in a high-risk population publication-title: Blood – volume: 45 start-page: 797 year: 2007 end-page: 805 ident: bib0041 article-title: The model for end-stage liver disease (MELD) publication-title: Hepatology – volume: 2013 start-page: 815105 year: 2013 ident: bib0025 article-title: Liver injury induced by anticancer chemotherapy and radiation therapy publication-title: Int J Hepatol – volume: 7 start-page: 587 year: 1981 end-page: 591 ident: bib0003 article-title: The palliation of hepatic metastases: Results of the Radiation Therapy Oncology Group pilot study publication-title: Int J Radiat Oncol Biol Phys – volume: 59 start-page: 1864 year: 2014 end-page: 1873 ident: bib0096 article-title: Left-liver hypertrophy after therapeutic right-liver radioembolization is substantial but less than after portal vein embolization publication-title: Hepatology – volume: 8 start-page: 355 year: 2016 end-page: 367 ident: bib0060 article-title: Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? publication-title: World J Hepatol – volume: 41 start-page: 1751 year: 2016 end-page: 1757 ident: bib0078 article-title: Histogram analysis of noncancerous liver parenchyma on gadoxetic acid-enhanced MRI: Predictive value for liver function and pathology publication-title: Abdom Radiol (NY) – volume: 24 start-page: 5467 year: 2006 ident: bib0028 article-title: Chemotherapy-induced steatohepatitis in colorectal cancer patients publication-title: J Clin Oncol – volume: 66 start-page: 675 year: 2017 end-page: 676 ident: bib0068 article-title: Assessment of preoperative liver function based on indocyanine green clearance publication-title: Hepatology – volume: 69 start-page: 813 year: 2007 end-page: 819 ident: bib0100 article-title: Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys – volume: 53 start-page: 810 year: 2002 end-page: 821 ident: bib0006 article-title: Analysis of radiation-induced liver disease using the Lyman NTCP model publication-title: Int J Radiat Oncol Biol Phys – volume: 50 start-page: 283 year: 2005 end-page: 289 ident: bib0048 article-title: Factors affecting the quantitative liver-spleen scan in normal individuals publication-title: Dig Dis Sci – volume: 80 start-page: 221 year: 2014 end-page: 227 ident: bib0033 article-title: The role of endoscopy in the management of variceal hemorrhage publication-title: Gastrointest Endosc – volume: 7 start-page: 173 year: 2017 end-page: 182 ident: bib0044 article-title: Assessment of hepatic function decline after stereotactic body radiation therapy for primary liver cancer publication-title: Pract Radiat Oncol – volume: 122 start-page: 130 year: 2017 end-page: 136 ident: bib0093 article-title: Central liver toxicity after SBRT: An expanded analysis and predictive nomogram publication-title: Radiother Oncol – volume: 21 start-page: 109 year: 1991 end-page: 122 ident: bib0091 article-title: Tolerance of normal tissue to therapeutic irradiation publication-title: Int J Radiat Oncol Biol Phys – volume: 21 start-page: 256 year: 2011 end-page: 263 ident: bib0040 article-title: Hepatic radiation toxicity: Avoidance and amelioration publication-title: Semin Radiat Oncol – volume: 6 start-page: E44 year: 2015 end-page: E47 ident: bib0057 article-title: Functional imaging of radiation liver injury in a liver metastasis patient: Imaging and pathologic correlation publication-title: J Gastrointest Oncol – volume: 14 start-page: 1029 year: 1991 end-page: 1034 ident: bib0066 article-title: Predictors of one-year pretransplant survival in patients with cirrhosis publication-title: Hepatology – volume: 2016 start-page: 5234969 year: 2016 ident: bib0036 article-title: Evaluation of antiviral therapy performed after curative therapy in patients with HBV-related hepatocellular carcinoma: An updated meta-analysis publication-title: Can J Gastroenterol Hepatol – volume: 93 start-page: 200 year: 1965 end-page: 208 ident: bib0089 article-title: Radiation hepatitis publication-title: Am J Roentgenol Radium Ther Nucl Med – volume: 9 start-page: e112731 year: 2014 ident: bib0111 article-title: Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity publication-title: PLoS One – volume: 89 start-page: 1501 year: 1997 end-page: 1506 ident: bib0108 article-title: Treatment of hepatic venocclusive disease with recombinant human tissue plasminogen activator and heparin in 42 marrow transplant patients publication-title: Blood – volume: 57 start-page: 294 year: 2016 end-page: 300 ident: bib0083 article-title: Threshold doses and prediction of visually apparent liver dysfunction after stereotactic body radiation therapy in cirrhotic and normal livers using magnetic resonance imaging publication-title: J Radiat Res – volume: 40 start-page: 797 year: 2016 end-page: 800 ident: bib0079 article-title: Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: Validation with ICG tests and parenchymal cell volume publication-title: Clin Imaging – volume: 15 start-page: 279 year: 2005 end-page: 283 ident: bib0090 article-title: Partial volume tolerance of the liver to radiation publication-title: Semin Radiat Oncol – volume: 70 start-page: 154 year: 2008 end-page: 160 ident: bib0071 article-title: Liver function after irradiation based on computed tomographic portal vein perfusion imaging publication-title: Int J Radiat Oncol Biol Phys – volume: 33 start-page: 259 year: 2008 end-page: 267 ident: bib0010 article-title: Proton radiotherapy for liver tumors: Dosimetric advantages over photon plans publication-title: Med Dosim – volume: 22 start-page: 1539 year: 1990 end-page: 1541 ident: bib0065 article-title: Assessment of liver function in the early postoperative period after liver transplantation with ICG, MEGX, and GAL tests publication-title: Transplant Proc – volume: 26 start-page: 657 year: 2008 end-page: 664 ident: bib0007 article-title: Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma publication-title: J Clin Oncol – volume: 57 start-page: 421 year: 2012 end-page: 429 ident: bib0076 article-title: Primovist, Eovist: What to expect? publication-title: J Hepatol – volume: 83 start-page: 1441 year: 2012 end-page: 1447 ident: bib0110 article-title: A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy publication-title: Int J Radiat Oncol Biol Phys – volume: 6 start-page: 40 year: 2011 ident: bib0084 article-title: Quantitative in vivo assessment of radiation injury of the liver using Gd-EOB-DTPA enhanced MRI: Tolerance dose of small liver volumes publication-title: Radiat Oncol – volume: 27 start-page: 240 year: 2017 end-page: 246 ident: bib0102 article-title: Stereotactic body radiotherapy for liver metastases publication-title: Semin Radiat Oncol – volume: 83 start-page: 477 year: 2014 end-page: 481 ident: bib0077 article-title: Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism publication-title: Med Hypotheses – volume: 122 start-page: 77 year: 1990 end-page: 85 ident: bib0022 article-title: Transforming growth factor-beta 1 expression in irradiated liver publication-title: Radiat Res – volume: 27 start-page: 350 year: 2017 end-page: 357 ident: bib0099 article-title: Radiation-induced liver toxicity publication-title: Semin Radiat Oncol – volume: 63 start-page: 41 year: 2002 end-page: 45 ident: bib0018 article-title: Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: Clinical manifestation and dosimetric description publication-title: Radiother Oncol – volume: 32 start-page: 1165 year: 2012 end-page: 1171 ident: bib0070 article-title: The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma publication-title: Liver Int – volume: 85 start-page: 258 year: 2013 end-page: 263 ident: bib0072 article-title: Prediction of liver function by using magnetic resonance-based portal venous perfusion imaging publication-title: Int J Radiat Oncol Biol Phys – volume: 32 start-page: 660 year: 2014 end-page: 664 ident: bib0080 article-title: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MR finding of radiation-induced hepatic injury: Relationship to absorbed dose and time course after irradiation publication-title: Magn Reson Imaging – volume: 7 start-page: 197 year: 2010 end-page: 204 ident: bib0073 article-title: Ben-Josef E: Adaptive trial of personalized radiotherapy for intrahepatic cancer publication-title: Per Med – volume: 42 start-page: 97 year: 2017 end-page: 103 ident: bib0086 article-title: Functional image-guided stereotactic body radiation therapy planning for patients with hepatocellular carcinoma publication-title: Med Dosim – volume: 45 start-page: 831 year: 2006 end-page: 837 ident: bib0052 article-title: Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study publication-title: Acta Oncol – volume: 115 start-page: 203 year: 2015 end-page: 210 ident: bib0059 article-title: Differential hepatic avoidance radiation therapy: Proof of concept in hepatocellular carcinoma patients publication-title: Radiother Oncol – volume: 122 start-page: 77 year: 1990 ident: 10.1016/j.semradonc.2018.06.007_bib0022 article-title: Transforming growth factor-beta 1 expression in irradiated liver publication-title: Radiat Res doi: 10.2307/3577586 – volume: 60 start-page: 1502 year: 2004 ident: 10.1016/j.semradonc.2018.06.007_bib0019 article-title: Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2004.05.048 – volume: 32 start-page: 660 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0080 article-title: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MR finding of radiation-induced hepatic injury: Relationship to absorbed dose and time course after irradiation publication-title: Magn Reson Imaging doi: 10.1016/j.mri.2014.02.019 – volume: 21 start-page: 256 year: 2011 ident: 10.1016/j.semradonc.2018.06.007_bib0040 article-title: Hepatic radiation toxicity: Avoidance and amelioration publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2011.05.003 – volume: 15 start-page: 279 year: 2005 ident: 10.1016/j.semradonc.2018.06.007_bib0090 article-title: Partial volume tolerance of the liver to radiation publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2005.04.005 – volume: 83 start-page: 477 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0077 article-title: Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism publication-title: Med Hypotheses doi: 10.1016/j.mehy.2014.08.004 – volume: 61 start-page: 6465 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0087 article-title: Optimizing global liver function in radiation therapy treatment planning publication-title: Phys Med Biol doi: 10.1088/0031-9155/61/17/6465 – volume: 34 start-page: 460 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0015 article-title: Multi-Institutional Phase II study of high-dose hypofractionated proton beam therapy in patients with localized, unresectable hepatocellular carcinoma and intrahepatic cholangiocarcinoma publication-title: J Clin Oncol doi: 10.1200/JCO.2015.64.2710 – volume: 163 start-page: 515 year: 1992 ident: 10.1016/j.semradonc.2018.06.007_bib0064 article-title: Indocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients publication-title: Am J Surg doi: 10.1016/0002-9610(92)90400-L – volume: 70 start-page: 154 year: 2008 ident: 10.1016/j.semradonc.2018.06.007_bib0071 article-title: Liver function after irradiation based on computed tomographic portal vein perfusion imaging publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2007.05.078 – volume: 48 start-page: 597 year: 1966 ident: 10.1016/j.semradonc.2018.06.007_bib0002 article-title: The human liver after radiation injury. A form of veno-occlusive disease publication-title: Am J Pathol – volume: 6 start-page: E44 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0057 article-title: Functional imaging of radiation liver injury in a liver metastasis patient: Imaging and pathologic correlation publication-title: J Gastrointest Oncol – volume: 83 start-page: 1441 year: 2012 ident: 10.1016/j.semradonc.2018.06.007_bib0110 article-title: A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2011.10.020 – volume: 22 start-page: 1539 year: 1990 ident: 10.1016/j.semradonc.2018.06.007_bib0065 article-title: Assessment of liver function in the early postoperative period after liver transplantation with ICG, MEGX, and GAL tests publication-title: Transplant Proc – volume: 14 start-page: 1029 year: 1991 ident: 10.1016/j.semradonc.2018.06.007_bib0066 article-title: Predictors of one-year pretransplant survival in patients with cirrhosis publication-title: Hepatology doi: 10.1002/hep.1840140614 – volume: 26 start-page: 128 year: 1997 ident: 10.1016/j.semradonc.2018.06.007_bib0023 article-title: Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: Activation of hepatic stellate cells as an early event publication-title: Hepatology doi: 10.1002/hep.510260117 – volume: 69 start-page: 813 year: 2007 ident: 10.1016/j.semradonc.2018.06.007_bib0100 article-title: Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2007.04.005 – volume: 66 start-page: 675 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0068 article-title: Assessment of preoperative liver function based on indocyanine green clearance publication-title: Hepatology doi: 10.1002/hep.29232 – volume: 76 start-page: S94 year: 2010 ident: 10.1016/j.semradonc.2018.06.007_bib0039 article-title: Radiation-associated liver injury publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2009.06.092 – volume: 24 start-page: 2065 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0027 article-title: Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases publication-title: J Clin Oncol doi: 10.1200/JCO.2005.05.3074 – volume: 74 start-page: 831 year: 2009 ident: 10.1016/j.semradonc.2018.06.007_bib0012 article-title: A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2008.10.073 – volume: 11 start-page: 240 year: 2001 ident: 10.1016/j.semradonc.2018.06.007_bib0098 article-title: Partial irradiation of the liver publication-title: Semin Radiat Oncol doi: 10.1053/srao.2001.23485 – volume: 15 start-page: 1358 year: 2009 ident: 10.1016/j.semradonc.2018.06.007_bib0063 article-title: Plasma disappearance rate of indocyanine green: A tool to evaluate early graft outcome after liver transplantation publication-title: Liver Transpl doi: 10.1002/lt.21805 – volume: 7 start-page: 197 year: 2010 ident: 10.1016/j.semradonc.2018.06.007_bib0073 article-title: Ben-Josef E: Adaptive trial of personalized radiotherapy for intrahepatic cancer publication-title: Per Med doi: 10.2217/pme.10.5 – volume: 30 start-page: 142 year: 1999 ident: 10.1016/j.semradonc.2018.06.007_bib0067 article-title: Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function publication-title: J Hepatol doi: 10.1016/S0168-8278(99)80018-X – volume: 63 start-page: 41 year: 2002 ident: 10.1016/j.semradonc.2018.06.007_bib0018 article-title: Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: Clinical manifestation and dosimetric description publication-title: Radiother Oncol doi: 10.1016/S0167-8140(02)00061-0 – volume: 89 start-page: 1501 year: 1997 ident: 10.1016/j.semradonc.2018.06.007_bib0108 article-title: Treatment of hepatic venocclusive disease with recombinant human tissue plasminogen activator and heparin in 42 marrow transplant patients publication-title: Blood doi: 10.1182/blood.V89.5.1501 – volume: 85 start-page: 258 year: 2013 ident: 10.1016/j.semradonc.2018.06.007_bib0072 article-title: Prediction of liver function by using magnetic resonance-based portal venous perfusion imaging publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2012.02.037 – volume: 115 start-page: 203 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0059 article-title: Differential hepatic avoidance radiation therapy: Proof of concept in hepatocellular carcinoma patients publication-title: Radiother Oncol doi: 10.1016/j.radonc.2015.04.011 – volume: 13 start-page: 851 year: 2007 ident: 10.1016/j.semradonc.2018.06.007_bib0024 article-title: Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-06-2459 – volume: 31 start-page: 3647 year: 2013 ident: 10.1016/j.semradonc.2018.06.007_bib0035 article-title: Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma: A two-stage longitudinal clinical study publication-title: J Clin Oncol doi: 10.1200/JCO.2012.48.5896 – volume: 7 start-page: 173 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0044 article-title: Assessment of hepatic function decline after stereotactic body radiation therapy for primary liver cancer publication-title: Pract Radiat Oncol doi: 10.1016/j.prro.2016.10.003 – volume: 50 start-page: 283 year: 2005 ident: 10.1016/j.semradonc.2018.06.007_bib0048 article-title: Factors affecting the quantitative liver-spleen scan in normal individuals publication-title: Dig Dis Sci doi: 10.1007/s10620-005-1596-y – volume: 12 start-page: e0181488 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0097 article-title: Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0181488 – volume: 38 start-page: 577 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0055 article-title: Assessment of functional liver reserve: Old and new in 99mTc-sulfur colloid scintigraphy publication-title: Nucl Med Commun doi: 10.1097/MNM.0000000000000695 – volume: 57 start-page: 421 year: 2012 ident: 10.1016/j.semradonc.2018.06.007_bib0076 article-title: Primovist, Eovist: What to expect? publication-title: J Hepatol doi: 10.1016/j.jhep.2012.01.031 – volume: 24 start-page: 373 year: 1986 ident: 10.1016/j.semradonc.2018.06.007_bib0054 article-title: Fatal radiation hepatitis: A case report and review of the literature publication-title: Gynecol Oncol doi: 10.1016/0090-8258(86)90316-1 – volume: 80 start-page: 221 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0033 article-title: The role of endoscopy in the management of variceal hemorrhage publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2013.07.023 – volume: 21 start-page: 109 year: 1991 ident: 10.1016/j.semradonc.2018.06.007_bib0091 article-title: Tolerance of normal tissue to therapeutic irradiation publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(91)90171-Y – volume: 65 start-page: 734 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0037 article-title: Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: Data from three ANRS cohorts publication-title: J Hepatol doi: 10.1016/j.jhep.2016.05.045 – volume: 41 start-page: 1751 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0078 article-title: Histogram analysis of noncancerous liver parenchyma on gadoxetic acid-enhanced MRI: Predictive value for liver function and pathology publication-title: Abdom Radiol (NY) doi: 10.1007/s00261-016-0753-4 – volume: 2013 start-page: 815105 year: 2013 ident: 10.1016/j.semradonc.2018.06.007_bib0025 article-title: Liver injury induced by anticancer chemotherapy and radiation therapy publication-title: Int J Hepatol doi: 10.1155/2013/815105 – volume: 42 start-page: 97 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0086 article-title: Functional image-guided stereotactic body radiation therapy planning for patients with hepatocellular carcinoma publication-title: Med Dosim doi: 10.1016/j.meddos.2017.01.005 – volume: 22 start-page: 1113 year: 1995 ident: 10.1016/j.semradonc.2018.06.007_bib0046 article-title: The liver-spleen scan as a quantitative liver function test: Correlation with liver severity at peritoneoscopy publication-title: Hepatology doi: 10.1002/hep.1840220415 – volume: 92 start-page: 737 year: 1998 ident: 10.1016/j.semradonc.2018.06.007_bib0109 article-title: Treatment of severe veno-occlusive disease with defibrotide: Compassionate use results in response without significant toxicity in a high-risk population publication-title: Blood – volume: 23 start-page: 781 year: 1992 ident: 10.1016/j.semradonc.2018.06.007_bib0021 article-title: The use of 3-D dose volume analysis to predict radiation hepatitis publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(92)90651-W – volume: 59 start-page: 1864 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0096 article-title: Left-liver hypertrophy after therapeutic right-liver radioembolization is substantial but less than after portal vein embolization publication-title: Hepatology doi: 10.1002/hep.26947 – volume: 62 start-page: 1371 year: 2005 ident: 10.1016/j.semradonc.2018.06.007_bib0105 article-title: A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2005.01.002 – volume: 27 start-page: 240 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0102 article-title: Stereotactic body radiotherapy for liver metastases publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2017.02.004 – volume: 7 start-page: 587 year: 1981 ident: 10.1016/j.semradonc.2018.06.007_bib0003 article-title: The palliation of hepatic metastases: Results of the Radiation Therapy Oncology Group pilot study publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(81)90370-9 – volume: 27 start-page: 1572 year: 2009 ident: 10.1016/j.semradonc.2018.06.007_bib0092 article-title: Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases publication-title: J Clin Oncol doi: 10.1200/JCO.2008.19.6329 – volume: 21 start-page: 264 year: 2011 ident: 10.1016/j.semradonc.2018.06.007_bib0103 article-title: Radiation therapy for liver metastases publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2011.05.006 – volume: 61 start-page: 967 year: 2012 ident: 10.1016/j.semradonc.2018.06.007_bib0031 article-title: The window hypothesis: Haemodynamic and non-haemodynamic effects of beta-blockers improve survival of patients with cirrhosis during a window in the disease publication-title: Gut doi: 10.1136/gutjnl-2011-301348 – volume: 12 start-page: 27 year: 1924 ident: 10.1016/j.semradonc.2018.06.007_bib0001 article-title: The occurrence of hepatic lesions in patients treated by intensive deep roentgen irradiation publication-title: Am J Roentgenol Radium Ther Nucl Med – volume: 8 start-page: 229 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0034 article-title: Viral hepatitis and hepatocellular carcinoma: Etiology and management publication-title: J Gastrointest Oncol doi: 10.21037/jgo.2017.03.14 – volume: 245 start-page: 923 year: 2007 ident: 10.1016/j.semradonc.2018.06.007_bib0026 article-title: Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: A matched case-control study publication-title: Ann Surg doi: 10.1097/01.sla.0000251747.80025.b7 – volume: 26 start-page: 657 year: 2008 ident: 10.1016/j.semradonc.2018.06.007_bib0007 article-title: Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma publication-title: J Clin Oncol doi: 10.1200/JCO.2007.14.3529 – ident: 10.1016/j.semradonc.2018.06.007_bib0016 doi: 10.1200/JCO.2015.61.3778 – volume: 33 start-page: 550 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0043 article-title: Assessment of liver function in patients with hepatocellular carcinoma: A new evidence-based approach-the ALBI grade publication-title: J Clin Oncol doi: 10.1200/JCO.2014.57.9151 – volume: 88 start-page: 306 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0082 article-title: Threshold doses for focal liver reaction after stereotactic ablative body radiation therapy for small hepatocellular carcinoma depend on liver function: Evaluation on magnetic resonance imaging with Gd-EOB-DTPA publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2013.10.045 – volume: 16 start-page: 2246 year: 1998 ident: 10.1016/j.semradonc.2018.06.007_bib0005 article-title: Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model publication-title: J Clin Oncol doi: 10.1200/JCO.1998.16.6.2246 – volume: 4 start-page: 53 year: 1984 ident: 10.1016/j.semradonc.2018.06.007_bib0047 article-title: Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis publication-title: Hepatology doi: 10.1002/hep.1840040109 – volume: 27 start-page: 117 year: 1993 ident: 10.1016/j.semradonc.2018.06.007_bib0004 article-title: Accelerated hyperfractionated hepatic irradiation in the management of patients with liver metastases: Results of the RTOG dose escalating protocol publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(93)90428-X – volume: 7 start-page: e331 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0106 article-title: Dosimetric analysis of liver toxicity after liver metastasis stereotactic body radiation therapy publication-title: Pract Radiat Oncol doi: 10.1016/j.prro.2017.03.004 – volume: 96 start-page: E179 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0050 article-title: Hepatic failure progression is not hastened in intermediate-risk hepatocellular carcinoma after stereotactic radiation therapy (SRT) with functional treatment planning publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2016.06.1041 – volume: 45 start-page: 831 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0052 article-title: Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study publication-title: Acta Oncol doi: 10.1080/02841860600897934 – start-page: 663 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0032 article-title: Current Medical Diagnosis & Treatment – ident: 10.1016/j.semradonc.2018.06.007_bib0058 doi: 10.7759/cureus.1674 – volume: 65 start-page: 426 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0020 article-title: Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2005.12.031 – volume: 94 start-page: 181 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0088 article-title: Local and global function model of the liver publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2015.09.044 – volume: 9 start-page: e112731 year: 2014 ident: 10.1016/j.semradonc.2018.06.007_bib0111 article-title: Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity publication-title: PLoS One doi: 10.1371/journal.pone.0112731 – volume: 23 start-page: 1839 year: 2005 ident: 10.1016/j.semradonc.2018.06.007_bib0013 article-title: Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma publication-title: J Clin Oncol doi: 10.1200/JCO.2005.00.620 – volume: 35 start-page: 49 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0061 article-title: Current use and perspective of indocyanine green clearance in liver diseases publication-title: Anaesth Crit Care Pain Med doi: 10.1016/j.accpm.2015.06.006 – volume: 93 start-page: 200 year: 1965 ident: 10.1016/j.semradonc.2018.06.007_bib0089 article-title: Radiation hepatitis publication-title: Am J Roentgenol Radium Ther Nucl Med – volume: 25 start-page: 297 year: 2011 ident: 10.1016/j.semradonc.2018.06.007_bib0062 article-title: Non-invasive ICG-clearance: A useful tool for the management of hepatic artery thrombosis following liver transplantation publication-title: Clin Transplant doi: 10.1111/j.1399-0012.2010.01252.x – volume: 33 start-page: 1075 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0075 article-title: 3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function publication-title: Magn Reson Imaging doi: 10.1016/j.mri.2015.06.013 – volume: 53 start-page: 810 year: 2002 ident: 10.1016/j.semradonc.2018.06.007_bib0006 article-title: Analysis of radiation-induced liver disease using the Lyman NTCP model publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)02846-8 – volume: 57 start-page: 294 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0083 article-title: Threshold doses and prediction of visually apparent liver dysfunction after stereotactic body radiation therapy in cirrhotic and normal livers using magnetic resonance imaging publication-title: J Radiat Res doi: 10.1093/jrr/rrw008 – volume: 45 start-page: 856 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0008 article-title: Individualized image guided iso-NTCP based liver cancer SBRT publication-title: Acta Oncol doi: 10.1080/02841860600936369 – volume: 375 start-page: 767 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0030 article-title: Treatment of patients with cirrhosis publication-title: N Engl J Med doi: 10.1056/NEJMra1504367 – volume: 95 start-page: e2877 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0038 article-title: Child-Pugh versus MELD score for the assessment of prognosis in liver cirrhosis: A systematic review and meta-analysis of observational studies publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000002877 – volume: 6 start-page: 40 year: 2011 ident: 10.1016/j.semradonc.2018.06.007_bib0084 article-title: Quantitative in vivo assessment of radiation injury of the liver using Gd-EOB-DTPA enhanced MRI: Tolerance dose of small liver volumes publication-title: Radiat Oncol doi: 10.1186/1748-717X-6-40 – volume: 97 start-page: 939 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0107 article-title: Predictors of liver toxicity following stereotactic body radiation therapy for hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2017.01.221 – volume: 8 start-page: 355 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0060 article-title: Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? publication-title: World J Hepatol doi: 10.4254/wjh.v8.i7.355 – volume: 2016 start-page: 5234969 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0036 article-title: Evaluation of antiviral therapy performed after curative therapy in patients with HBV-related hepatocellular carcinoma: An updated meta-analysis publication-title: Can J Gastroenterol Hepatol – volume: 31 start-page: 1631 year: 2013 ident: 10.1016/j.semradonc.2018.06.007_bib0009 article-title: Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma publication-title: J Clin Oncol doi: 10.1200/JCO.2012.44.1659 – volume: 100 start-page: 131 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0069 article-title: Using Indocyanine Green extraction to predict liver function after stereotactic body radiation therapy for hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2017.09.032 – volume: 5 start-page: e443 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0053 article-title: Treatment variables related to liver toxicity in patients with hepatocellular carcinoma, Child-Pugh class A and B enrolled in a phase 1-2 trial of stereotactic body radiation therapy publication-title: Pract Radiat Oncol doi: 10.1016/j.prro.2015.02.007 – volume: 43 start-page: 209 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0101 article-title: Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy publication-title: Hepatology doi: 10.1002/hep.21051 – volume: 91 start-page: 986 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0094 article-title: Predictors of toxicity associated with stereotactic body radiation therapy to the central hepatobiliary tract publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2014.11.028 – volume: 359 start-page: 1018 year: 2008 ident: 10.1016/j.semradonc.2018.06.007_bib0042 article-title: Hyponatremia and mortality among patients on the liver-transplant waiting list publication-title: N Engl J Med doi: 10.1056/NEJMoa0801209 – volume: 200 start-page: 845 year: 2005 ident: 10.1016/j.semradonc.2018.06.007_bib0029 article-title: Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases publication-title: J Am Coll Surg doi: 10.1016/j.jamcollsurg.2005.01.024 – volume: 45 start-page: 848 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0104 article-title: Interim analysis of a prospective phase I/II trial of SBRT for liver metastases publication-title: Acta Oncol doi: 10.1080/02841860600904870 – volume: 48 start-page: 1000 year: 2008 ident: 10.1016/j.semradonc.2018.06.007_bib0045 article-title: Thrombocytopenia associated with chronic liver disease publication-title: J Hepatol doi: 10.1016/j.jhep.2008.03.009 – volume: 38 start-page: 367 year: 1997 ident: 10.1016/j.semradonc.2018.06.007_bib0095 article-title: Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: Analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(96)00587-1 – volume: 27 start-page: 350 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0099 article-title: Radiation-induced liver toxicity publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2017.04.002 – volume: 122 start-page: 1974 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0017 article-title: Solutions that enable ablative radiotherapy for large liver tumors: Fractionated dose painting, simultaneous integrated protection, motion management, and computed tomography image guidance publication-title: Cancer doi: 10.1002/cncr.29878 – volume: 32 start-page: 1165 year: 2012 ident: 10.1016/j.semradonc.2018.06.007_bib0070 article-title: The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma publication-title: Liver Int doi: 10.1111/j.1478-3231.2012.02784.x – volume: 60 start-page: 96 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0081 article-title: Hepatic reaction dose for parenchymal changes on Gd-EOB-DTPA-enhanced magnetic resonance images after stereotactic body radiation therapy for hepatocellular carcinoma publication-title: J Med Imaging Radiat Oncol doi: 10.1111/1754-9485.12393 – volume: 38 start-page: 213 year: 2015 ident: 10.1016/j.semradonc.2018.06.007_bib0085 article-title: Radiation-induced liver damage: Correlation of histopathology with hepatobiliary magnetic resonance imaging, a feasibility study publication-title: Cardiovasc Interventional Radiol doi: 10.1007/s00270-014-0872-7 – volume: 6 start-page: 57 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0056 article-title: Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients publication-title: EJNMMI Res doi: 10.1186/s13550-016-0212-9 – volume: 33 start-page: 259 year: 2008 ident: 10.1016/j.semradonc.2018.06.007_bib0010 article-title: Proton radiotherapy for liver tumors: Dosimetric advantages over photon plans publication-title: Med Dosim doi: 10.1016/j.meddos.2007.04.008 – ident: 10.1016/j.semradonc.2018.06.007_bib0014 doi: 10.1016/j.ijrobp.2010.07.015 – volume: 122 start-page: 130 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0093 article-title: Central liver toxicity after SBRT: An expanded analysis and predictive nomogram publication-title: Radiother Oncol doi: 10.1016/j.radonc.2016.10.024 – volume: 18 start-page: 88 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0051 article-title: Stereotactic body radiotherapy (SBRT) with or without surgery for primary and metastatic liver tumors publication-title: HPB (Oxford) doi: 10.1016/j.hpb.2015.07.007 – volume: 39 start-page: 7398 year: 2012 ident: 10.1016/j.semradonc.2018.06.007_bib0049 article-title: A method for registration of single photon emission computed tomography (SPECT) and computed tomography (CT) images for liver stereotactic radiotherapy (SRT) publication-title: Med Phys doi: 10.1118/1.4766877 – volume: 24 start-page: 5467 year: 2006 ident: 10.1016/j.semradonc.2018.06.007_bib0028 article-title: Chemotherapy-induced steatohepatitis in colorectal cancer patients publication-title: J Clin Oncol doi: 10.1200/JCO.2006.08.1828 – volume: 4 start-page: 40 year: 2017 ident: 10.1016/j.semradonc.2018.06.007_bib0074 article-title: Individualized adaptive stereotactic body radiotherapy for liver tumors in patients at high risk for liver damage: A phase 2 clinical trial publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2017.2303 – volume: 50 start-page: 823 year: 2011 ident: 10.1016/j.semradonc.2018.06.007_bib0011 article-title: Normal liver tissue sparing by intensity-modulated proton stereotactic body radiotherapy for solitary liver tumours publication-title: Acta Oncol doi: 10.3109/0284186X.2011.590526 – volume: 40 start-page: 797 year: 2016 ident: 10.1016/j.semradonc.2018.06.007_bib0079 article-title: Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: Validation with ICG tests and parenchymal cell volume publication-title: Clin Imaging doi: 10.1016/j.clinimag.2016.03.003 – volume: 45 start-page: 797 year: 2007 ident: 10.1016/j.semradonc.2018.06.007_bib0041 article-title: The model for end-stage liver disease (MELD) publication-title: Hepatology doi: 10.1002/hep.21563 |
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| SubjectTerms | Dose-Response Relationship, Radiation Humans Liver - radiation effects Liver Diseases - etiology Liver Neoplasms - radiotherapy Radiation Injuries - etiology Radiometry Radiotherapy - adverse effects Risk Factors |
| Title | Radiation-Induced Liver Disease and Modern Radiotherapy |
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