Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synt...

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Bibliographic Details
Published iniScience Vol. 23; no. 1; p. 100795
Main Authors Ren, Hengqian, Shi, Chengyou, Zhao, Huimin
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 24.01.2020
Elsevier
Subjects
BASIC BIOLOGICAL SCIENCES
Bioengineering
Bioinformatics
Biological Sciences
biosynthesis
biosynthetic gene clusters
biosynthetic pathways
Metabolic Engineering
natural products
Review
synthetic biology
Bioengineering
Metabolic Engineering
Biological Sciences
Bioinformatics
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Summary:Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs of pharmaceutical importance. [Display omitted] Biological Sciences; Bioengineering; Metabolic Engineering; Bioinformatics
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SC0018420; SC0018260; GM077596; AI144967
USDOE Office of Science (SC), Biological and Environmental Research (BER)
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2019.100795