Cohesin mutations are synthetic lethal with stimulation of WNT signaling - Chin, Chue Vin; Antony, Jisha; Ketharnathan, Sarada; Labudina, Anastasia; Gimenez, Gregory; Parsons, Kate M; He, Jinshu; George, Amee J; Pallotta, Maria Michela; Musio, Antonio; Braithwaite, Antony; Guilford, Parry; et al. (eLife, 2020)
Keywords: Animals; Cancer Biology; Carcinogenesis - genetics; Cell Cycle Proteins - genetics; Cell Division; Cell Line; Chromosomal Proteins, Non-Histone - genetics; Chromosomes and Gene Expression; cohesin; Cohesins; DNA damage; Drug approval; drug screen; Genes; Genetic aspects; Health aspects; Humans; synthetic lethal; Synthetic Lethal Mutations - genetics; transcription; Transcription (Genetics); wnt signaling; Wnt Signaling Pathway - physiology; Zebrafish; synthetic lethal; wnt signaling; cohesin; transcription; chromosomes; cancer biology; drug screen; zebrafish; human; gene expression