Cohesin mutations are synthetic lethal with stimulation of WNT signaling
Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality wit...
Saved in:
| Published in | eLife Vol. 9 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
eLife Science Publications, Ltd
07.12.2020
eLife Sciences Publications, Ltd eLife Sciences Publications Ltd |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top ‘hits’ was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in
STAG2
-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits
stag2b
and
rad21
. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. |
|---|---|
| AbstractList | Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top 'hits' was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of [beta]-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top ‘hits’ was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2 -mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21 . Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top 'hits' was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in -mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits and . Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top 'hits' was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers.Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top 'hits' was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top ‘hits’ was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers. |
| Audience | Academic |
| Author | Gimenez, Gregory He, Jinshu Horsfield, Julia A Guilford, Parry Pallotta, Maria Michela Hannan, Ross D Parsons, Kate M Labudina, Anastasia Musio, Antonio Ketharnathan, Sarada Braithwaite, Antony Chin, Chue Vin Antony, Jisha George, Amee J |
| Author_xml | – sequence: 1 givenname: Chue Vin surname: Chin fullname: Chin, Chue Vin organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand – sequence: 2 givenname: Jisha surname: Antony fullname: Antony, Jisha organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand – sequence: 3 givenname: Sarada surname: Ketharnathan fullname: Ketharnathan, Sarada organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand – sequence: 4 givenname: Anastasia surname: Labudina fullname: Labudina, Anastasia organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand – sequence: 5 givenname: Gregory surname: Gimenez fullname: Gimenez, Gregory organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand – sequence: 6 givenname: Kate M surname: Parsons fullname: Parsons, Kate M organization: The John Curtin School of Medical Research, The Australian National University, Canberra, Australia – sequence: 7 givenname: Jinshu surname: He fullname: He, Jinshu organization: The John Curtin School of Medical Research, The Australian National University, Canberra, Australia – sequence: 8 givenname: Amee J orcidid: 0000-0002-0265-4476 surname: George fullname: George, Amee J organization: The John Curtin School of Medical Research, The Australian National University, Canberra, Australia – sequence: 9 givenname: Maria Michela surname: Pallotta fullname: Pallotta, Maria Michela organization: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy – sequence: 10 givenname: Antonio orcidid: 0000-0001-7701-6543 surname: Musio fullname: Musio, Antonio organization: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy – sequence: 11 givenname: Antony surname: Braithwaite fullname: Braithwaite, Antony organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand – sequence: 12 givenname: Parry surname: Guilford fullname: Guilford, Parry organization: Department of Biochemistry, University of Otago, Dunedin, New Zealand – sequence: 13 givenname: Ross D surname: Hannan fullname: Hannan, Ross D organization: The John Curtin School of Medical Research, The Australian National University, Canberra, Australia, Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia, School of Biomedical Sciences, University of Queensland, St Lucia, Australia – sequence: 14 givenname: Julia A orcidid: 0000-0002-9536-7790 surname: Horsfield fullname: Horsfield, Julia A organization: Department of Pathology, Otago Medical School, University of Otago, Dunedin, New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand, Genetics Otago Research Centre, University of Otago, Dunedin, New Zealand |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33284104$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkt9r1TAUx4tM3Jx78l0Kvihyr0nzsy_CuKi7cJmgE30LaXraZrTJbFJ1_73Z7TZWWfKQcPL5fjmHfJ9nB847yLKXGK0FY_Q97GwDa44pYk-yowIxtEKS_jx4cD_MTkK4RGkJKiUun2WHhBSSYkSPsrON7yBYlw9T1NF6F3I9Qh6uXewgWpP3EDvd539s7PIQ7TD1eyz3Tf7j_CIPtnW6t659kT1tdB_g5PY8zr5_-nixOVvtvnzebk53K8OojCtJS10QwoShrNKVELosQda8wZigSiPBMC9YA6XhBouKFrWkVVVJUhYMSSjJcbadfWuvL9XVaAc9XiuvrdoX_NgqPabGe1CUSyqkLiluCDUgywoRTDQFbowoRJO8PsxeV1M1QG3AxVH3C9Pli7Odav1vJQTlaYpk8ObWYPS_JghRDTYY6HvtwE9BFZQLSQlnLKGvZ7TVqTXrGp8czQ2uTjllhAiMUaLWj1Bp1zBYk76-sam-ELxdCBIT4W9s9RSC2n77umRfPRz3fs67NCQAz4AZfQgjNMrYORWpC9srjNRN6NQ-dGofuqR595_mzvYx-h-zoNWt |
| CitedBy_id | crossref_primary_10_3389_fmed_2022_832312 crossref_primary_10_1016_j_blre_2023_101154 crossref_primary_10_1093_bfgp_elab008 crossref_primary_10_1093_g3journal_jkab426 crossref_primary_10_3390_cancers13164144 crossref_primary_10_1016_j_jbc_2024_107341 crossref_primary_10_3389_fmolb_2021_709232 crossref_primary_10_3390_ijms22136788 crossref_primary_10_1038_s41586_023_06340_w crossref_primary_10_1038_s41598_022_15081_1 crossref_primary_10_1242_dev_202593 crossref_primary_10_1002_advs_202302494 crossref_primary_10_1152_ajpcell_00657_2024 crossref_primary_10_1016_j_cels_2024_01_009 crossref_primary_10_1091_mbc_E22_12_0557 crossref_primary_10_1111_febs_16362 crossref_primary_10_3390_cells13070608 crossref_primary_10_1093_g3journal_jkac157 crossref_primary_10_1186_s13059_024_03351_2 crossref_primary_10_1002_2211_5463_13474 crossref_primary_10_33808_clinexphealthsci_1330630 crossref_primary_10_1038_s41375_021_01414_y |
| Cites_doi | 10.1016/j.trecan.2019.07.001 10.1182/blood-2013-07-518746 10.1158/1535-7163.MCT-14-1092 10.1038/nprot.2013.143 10.1074/jbc.M115.704627 10.1593/neo.121480 10.7554/eLife.52091 10.1016/j.cell.2018.03.072 10.1007/978-1-4939-6545-8_7 10.1146/annurev.cellbio.20.010403.113126 10.1182/blood-2014-04-567057 10.2174/187152007781668715 10.1242/dev.002485 10.1038/ng.2731 10.1186/s13046-019-1116-0 10.1097/MOH.0000000000000405 10.1084/jem.20151323 10.1038/nrc3579 10.1093/bioinformatics/btt656 10.1056/NEJMp1607591 10.1126/science.1186624 10.1038/s41568-020-0270-1 10.1093/nar/gkaa284 10.1371/journal.pgen.1002574 10.1038/s41576-018-0060-8 10.1101/cshperspect.a026476 10.1186/s13059-014-0550-8 10.1016/j.ydbio.2012.03.023 10.1016/j.tig.2012.12.004 10.1038/cddis.2013.371 10.1101/gad.1844309 10.1371/journal.pone.0125028 10.1016/j.bbagrm.2014.12.011 10.1172/JCI98727 10.1126/science.1248012 10.1093/hmg/ddu394 10.1371/journal.pone.0006936 10.1182/blood.V126.23.1221.1221 10.1089/omi.2011.0118 10.1016/j.celrep.2014.10.059 10.1074/jbc.M209511200 10.1038/s41408-017-0022-y 10.3109/10428194.2011.613133 10.1084/jem.20151317 10.1039/C5MB00663E 10.1007/s12185-016-2119-7 10.1016/j.molcel.2015.04.001 10.1186/s13023-017-0723-0 10.1158/1535-7163.MCT-13-0749 10.1016/j.devcel.2009.06.016 10.1016/j.bbcan.2016.05.002 10.1101/gad.233791.113 10.1038/s41467-019-09659-z 10.1038/sj.onc.1207892 10.1016/j.celrep.2016.02.082 10.1371/journal.pgen.1002749 10.1091/mbc.e13-07-0377 10.1097/01.moh.0000133649.61121.ec 10.1038/s41598-018-19173-9 10.1016/j.jcmgh.2020.04.007 10.7554/eLife.18126 10.1093/jmcb/mjz114 10.1038/ng.2759 10.1038/s41586-020-2428-0 10.1056/NEJMoa1516192 10.1016/j.cub.2012.02.046 10.1093/hmg/ddv402 10.7554/eLife.26980 10.1084/jem.20190787 10.1016/j.yexcr.2009.12.018 10.3324/haematol.2018.200899 10.15252/embj.201798004 10.1080/19491034.2020.1782024 10.3389/fcell.2020.617545 10.1093/hmg/ddy203 10.1016/j.tig.2020.03.001 10.1038/nmeth.3853 10.3389/fgene.2012.00171 10.1016/j.devcel.2017.02.001 10.1126/science.abb0981 10.1186/s12885-017-3689-3 10.18632/oncotarget.16838 10.1016/j.stem.2015.09.017 |
| ContentType | Journal Article |
| Copyright | 2020, Chin et al. COPYRIGHT 2020 eLife Science Publications, Ltd. 2020, Chin et al 2020 Chin et al |
| Copyright_xml | – notice: 2020, Chin et al. – notice: COPYRIGHT 2020 eLife Science Publications, Ltd. – notice: 2020, Chin et al 2020 Chin et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 7X8 5PM DOA |
| DOI | 10.7554/eLife.61405 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2050-084X |
| ExternalDocumentID | oai_doaj_org_article_468478a941f34ce89b0313a4e6cc727f PMC7746233 A645337110 33284104 10_7554_eLife_61405 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Health Research Council of New Zealand grantid: 19/415 – fundername: The Maurice Wilkins centre for Molecular Biodiscovery grantid: 3705733 – fundername: Health Research Council of New Zealand grantid: 15/229 – fundername: Associazione Italiana per la Ricerca sul Cancro grantid: IG23284 – fundername: ; grantid: 19/415 – fundername: ; grantid: 15/229 – fundername: ; grantid: IG23284 – fundername: ; grantid: 3705733 |
| GroupedDBID | 53G 5VS 7X7 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAKDD AAYXX ABUWG ACGFO ACGOD ACPRK ADBBV ADRAZ AENEX AFKRA AFPKN ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CITATION DIK DWQXO EMOBN FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IEA IHR INH INR ISR ITC KQ8 LK8 M1P M2P M48 M7P M~E NQS OK1 PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO RHI RNS RPM UKHRP CGR CUY CVF ECM EIF NPM PMFND 7X8 PPXIY PQGLB 5PM PJZUB PUEGO |
| ID | FETCH-LOGICAL-c548t-849a23357c45bab77a99e8d6f1130ba0751625fe9c6c17b42d84bbb8392508e93 |
| IEDL.DBID | M48 |
| ISSN | 2050-084X |
| IngestDate | Wed Aug 27 01:30:15 EDT 2025 Thu Aug 21 14:13:55 EDT 2025 Fri Jul 11 00:32:45 EDT 2025 Tue Jun 17 21:37:31 EDT 2025 Tue Jun 10 20:17:31 EDT 2025 Fri Jun 27 05:12:51 EDT 2025 Thu Apr 03 07:05:48 EDT 2025 Tue Jul 01 04:13:01 EDT 2025 Thu Apr 24 23:00:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | synthetic lethal wnt signaling cohesin transcription chromosomes cancer biology drug screen zebrafish human gene expression |
| Language | English |
| License | 2020, Chin et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c548t-849a23357c45bab77a99e8d6f1130ba0751625fe9c6c17b42d84bbb8392508e93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-7701-6543 0000-0002-0265-4476 0000-0002-9536-7790 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.7554/eLife.61405 |
| PMID | 33284104 |
| PQID | 2467843655 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_468478a941f34ce89b0313a4e6cc727f pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746233 proquest_miscellaneous_2467843655 gale_infotracmisc_A645337110 gale_infotracacademiconefile_A645337110 gale_incontextgauss_ISR_A645337110 pubmed_primary_33284104 crossref_citationtrail_10_7554_eLife_61405 crossref_primary_10_7554_eLife_61405 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-12-07 |
| PublicationDateYYYYMMDD | 2020-12-07 |
| PublicationDate_xml | – month: 12 year: 2020 text: 2020-12-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | eLife |
| PublicationTitleAlternate | Elife |
| PublicationYear | 2020 |
| Publisher | eLife Science Publications, Ltd eLife Sciences Publications, Ltd eLife Sciences Publications Ltd |
| Publisher_xml | – name: eLife Science Publications, Ltd – name: eLife Sciences Publications, Ltd – name: eLife Sciences Publications Ltd |
| References | Mondal (bib43) 2019; 10 Kon (bib30) 2013; 45 Thol (bib66) 2014; 123 Erbilgin (bib17) 2012; 53 Sarogni (bib59) 2019; 38 Niida (bib46) 2004; 23 Prossomariti (bib54) 2020; 10 Beghini (bib6) 2012; 14 van der Lelij (bib70) 2017; 6 Zaremba (bib85) 2007; 7 Wang (bib75) 2010; 327 Horsfield (bib27) 2012; 3 Moro (bib44) 2012; 366 Wang (bib76) 2016; 5 Telford (bib65) 2015; 14 Ran (bib55) 2013; 8 Pistocchi (bib53) 2013; 4 Shintomi (bib62) 2009; 23 van der Lelij (bib69) 2009; 4 De Koninck (bib14) 2016; 6 Mullenders (bib45) 2015; 212 Oginuma (bib48) 2017; 40 Ketharnathan (bib29) 2020; 8 Pan (bib50) 2020; 48 Romero-Pérez (bib57) 2019; 5 Galeev (bib19) 2016; 14 Hansen (bib23) 2020; 11 Emmrich (bib16) 2014; 28 Wutz (bib79) 2017; 36 O'Neil (bib47) 2013; 29 Yoshida (bib82) 2013; 45 Bailey (bib5) 2014; 13 MacDonald (bib35) 2009; 17 Cucco (bib11) 2014; 23 Liu (bib32) 2018; 128 Atkinson (bib3) 2015; 10 Mazumdar (bib39) 2017; 105 Cukrov (bib12) 2018; 27 McLellan (bib41) 2012; 8 Wendt (bib77) 2017; 1515 Hill (bib25) 2016; 1866 Rowley (bib58) 2018; 19 Tsai (bib68) 2017; 7 Westerfield (bib78) 1995 Dorsett (bib15) 2012; 22 Parks (bib52) 2013; 13 Harris (bib24) 2014; 25 Xu (bib81) 2014; 9 Ghiselli (bib20) 2003; 278 Grossman (bib21) 2016; 375 Mazzola (bib40) 2019; 104 Thota (bib67) 2014; 124 Mazumdar (bib38) 2015; 17 Vian (bib71) 2018; 173 Antony (bib2) 2020; 12 Kang (bib28) 2020; 217 Avagliano (bib4) 2017; 12 Love (bib34) 2014; 15 Oginuma (bib49) 2020; 584 Yu (bib84) 2016; 12 Antony (bib1) 2015; 1849 Horsfield (bib26) 2007; 134 Clark (bib9) 2017; 17 Schuster (bib60) 2015; 24 Waldman (bib74) 2020; 20 Mills (bib42) 2018; 8 Viny (bib73) 2018; 25 Rattis (bib56) 2004; 11 Sjögren (bib63) 2010; 316 Viny (bib72) 2015; 212 Dasgupta (bib13) 2016; 291 Tait (bib64) 1990; 50 Wutz (bib80) 2020; 9 Clevers (bib10) 2014; 346 Logan (bib33) 2004; 20 Estarás (bib18) 2015; 58 Benedetti (bib7) 2017; 8 Hafner (bib22) 2016; 13 Papaemmanuil (bib51) 2016; 374 Matto (bib36) 2015; 126 Liao (bib31) 2014; 30 Mayerova (bib37) 2020; 36 Shi (bib61) 2020; 368 Yu (bib83) 2012; 16 Bose (bib8) 2012; 8 |
| References_xml | – volume: 5 start-page: 506 year: 2019 ident: bib57 article-title: STAG mutations in cancer publication-title: Trends in Cancer doi: 10.1016/j.trecan.2019.07.001 – volume: 123 start-page: 914 year: 2014 ident: bib66 article-title: Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications publication-title: Blood doi: 10.1182/blood-2013-07-518746 – volume: 14 start-page: 1213 year: 2015 ident: bib65 article-title: Synthetic lethal screens identify vulnerabilities in GPCR signaling and cytoskeletal organization in E-Cadherin-Deficient cells publication-title: Molecular Cancer Therapeutics doi: 10.1158/1535-7163.MCT-14-1092 – volume: 8 start-page: 2281 year: 2013 ident: bib55 article-title: Genome engineering using the CRISPR-Cas9 system publication-title: Nature Protocols doi: 10.1038/nprot.2013.143 – volume: 291 start-page: 12761 year: 2016 ident: bib13 article-title: HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting Cohesin-dependent transcription in MCF7 Cancer cells publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M115.704627 – volume: 14 start-page: 1236 year: 2012 ident: bib6 article-title: Regeneration-associated WNT signaling is activated in long-term reconstituting AC133bright acute myeloid leukemia cells publication-title: Neoplasia doi: 10.1593/neo.121480 – volume: 9 year: 2020 ident: bib80 article-title: ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL publication-title: eLife doi: 10.7554/eLife.52091 – volume: 173 start-page: 1165 year: 2018 ident: bib71 article-title: The energetics and physiological impact of cohesin extrusion publication-title: Cell doi: 10.1016/j.cell.2018.03.072 – volume: 1515 start-page: 115 year: 2017 ident: bib77 article-title: Resolving the genomic localization of the kollerin Cohesin-Loader complex publication-title: Methods in Molecular Biology doi: 10.1007/978-1-4939-6545-8_7 – volume: 20 start-page: 781 year: 2004 ident: bib33 article-title: The wnt signaling pathway in development and disease publication-title: Annual Review of Cell and Developmental Biology doi: 10.1146/annurev.cellbio.20.010403.113126 – volume: 124 start-page: 1790 year: 2014 ident: bib67 article-title: Genetic alterations of the cohesin complex genes in myeloid malignancies publication-title: Blood doi: 10.1182/blood-2014-04-567057 – volume: 7 start-page: 515 year: 2007 ident: bib85 article-title: PARP inhibitor development for systemic Cancer targeting publication-title: Anti-Cancer Agents in Medicinal Chemistry doi: 10.2174/187152007781668715 – volume: 134 start-page: 2639 year: 2007 ident: bib26 article-title: Cohesin-dependent regulation of runx genes publication-title: Development doi: 10.1242/dev.002485 – volume: 45 start-page: 1232 year: 2013 ident: bib30 article-title: Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms publication-title: Nature Genetics doi: 10.1038/ng.2731 – volume: 38 year: 2019 ident: bib59 article-title: Overexpression of the cohesin-core subunit SMC1A contributes to colorectal Cancer development publication-title: Journal of Experimental & Clinical Cancer Research doi: 10.1186/s13046-019-1116-0 – volume: 25 start-page: 61 year: 2018 ident: bib73 article-title: Cohesin mutations in myeloid malignancies made simple publication-title: Current Opinion in Hematology doi: 10.1097/MOH.0000000000000405 – volume: 212 start-page: 1833 year: 2015 ident: bib45 article-title: Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms publication-title: Journal of Experimental Medicine doi: 10.1084/jem.20151323 – volume: 13 start-page: 611 year: 2013 ident: bib52 article-title: Disrupting proton dynamics and energy metabolism for Cancer therapy publication-title: Nature Reviews Cancer doi: 10.1038/nrc3579 – volume: 30 start-page: 923 year: 2014 ident: bib31 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 375 start-page: 1109 year: 2016 ident: bib21 article-title: Toward a shared vision for Cancer genomic data publication-title: New England Journal of Medicine doi: 10.1056/NEJMp1607591 – volume: 327 start-page: 1650 year: 2010 ident: bib75 article-title: The wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML publication-title: Science doi: 10.1126/science.1186624 – volume: 20 start-page: 504 year: 2020 ident: bib74 article-title: Emerging themes in cohesin Cancer biology publication-title: Nature Reviews Cancer doi: 10.1038/s41568-020-0270-1 – volume: 48 start-page: 5639 year: 2020 ident: bib50 article-title: Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA publication-title: Nucleic Acids Research doi: 10.1093/nar/gkaa284 – volume: 8 year: 2012 ident: bib41 article-title: Synthetic lethality of cohesins with PARPs and replication fork mediators publication-title: PLOS Genetics doi: 10.1371/journal.pgen.1002574 – volume: 19 start-page: 789 year: 2018 ident: bib58 article-title: Organizational principles of 3D genome architecture publication-title: Nature Reviews Genetics doi: 10.1038/s41576-018-0060-8 – volume: 6 year: 2016 ident: bib14 article-title: Cohesin mutations in cancer publication-title: Cold Spring Harbor Perspectives in Medicine doi: 10.1101/cshperspect.a026476 – volume: 15 year: 2014 ident: bib34 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biology doi: 10.1186/s13059-014-0550-8 – volume: 366 start-page: 327 year: 2012 ident: bib44 article-title: In vivo wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains publication-title: Developmental Biology doi: 10.1016/j.ydbio.2012.03.023 – volume: 29 start-page: 290 year: 2013 ident: bib47 article-title: Synthetic lethality and Cancer: cohesin and PARP at the replication fork publication-title: Trends in Genetics doi: 10.1016/j.tig.2012.12.004 – volume: 4 year: 2013 ident: bib53 article-title: Cornelia De Lange syndrome: nipbl haploinsufficiency downregulates canonical wnt pathway in zebrafish embryos and patients fibroblasts publication-title: Cell Death & Disease doi: 10.1038/cddis.2013.371 – volume: 23 start-page: 2224 year: 2009 ident: bib62 article-title: Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 publication-title: Genes & Development doi: 10.1101/gad.1844309 – volume: 10 year: 2015 ident: bib3 article-title: Activating the wnt/β-Catenin pathway for the treatment of melanoma--application of LY2090314, a novel selective inhibitor of glycogen synthase Kinase-3 publication-title: PLOS ONE doi: 10.1371/journal.pone.0125028 – volume: 1849 start-page: 257 year: 2015 ident: bib1 article-title: Cohesin modulates transcription of estrogen-responsive genes publication-title: Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms doi: 10.1016/j.bbagrm.2014.12.011 – volume: 128 start-page: 2951 year: 2018 ident: bib32 article-title: Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in Cancer publication-title: Journal of Clinical Investigation doi: 10.1172/JCI98727 – volume: 346 year: 2014 ident: bib10 article-title: Stem cell signaling an integral program for tissue renewal and regeneration: wnt signaling and stem cell control publication-title: Science doi: 10.1126/science.1248012 – volume: 23 start-page: 6773 year: 2014 ident: bib11 article-title: Mutant cohesin drives chromosomal instability in early colorectal adenomas publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddu394 – volume: 4 year: 2009 ident: bib69 article-title: The cellular phenotype of roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2 publication-title: PLOS ONE doi: 10.1371/journal.pone.0006936 – volume: 126 year: 2015 ident: bib36 article-title: Mutations in cohesin complex as potential targets for therapeutic intervention by PARP (Poly ADP ribose polymerase) Inhibitors in myelodysplastic syndrome publication-title: Blood doi: 10.1182/blood.V126.23.1221.1221 – volume: 16 start-page: 284 year: 2012 ident: bib83 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS: A Journal of Integrative Biology doi: 10.1089/omi.2011.0118 – volume: 9 start-page: 1781 year: 2014 ident: bib81 article-title: Cohesin Rad21 mediates loss of heterozygosity and is upregulated via wnt promoting transcriptional dysregulation in gastrointestinal tumors publication-title: Cell Reports doi: 10.1016/j.celrep.2014.10.059 – volume: 278 start-page: 20259 year: 2003 ident: bib20 article-title: The cohesin SMC3 is a target the for β-Catenin/TCF4 transactivation pathway publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M209511200 – volume: 7 year: 2017 ident: bib68 article-title: Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia publication-title: Blood Cancer Journal doi: 10.1038/s41408-017-0022-y – volume: 53 start-page: 508 year: 2012 ident: bib17 article-title: Genetic alterations in members of the wnt pathway in acute leukemia publication-title: Leukemia & Lymphoma doi: 10.3109/10428194.2011.613133 – volume: 212 start-page: 1819 year: 2015 ident: bib72 article-title: Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis publication-title: Journal of Experimental Medicine doi: 10.1084/jem.20151317 – volume: 12 start-page: 477 year: 2016 ident: bib84 article-title: ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization publication-title: Molecular BioSystems doi: 10.1039/C5MB00663E – volume: 105 start-page: 31 year: 2017 ident: bib39 article-title: The role of mutations in the cohesin complex in acute myeloid leukemia publication-title: International Journal of Hematology doi: 10.1007/s12185-016-2119-7 – volume: 58 start-page: 780 year: 2015 ident: bib18 article-title: SMADs and YAP compete to control elongation of β-catenin:lef-1-recruited RNAPII during hESC differentiation publication-title: Molecular Cell doi: 10.1016/j.molcel.2015.04.001 – volume: 12 year: 2017 ident: bib4 article-title: Integrating molecular and structural findings: wnt as a possible actor in shaping cognitive impairment in cornelia de lange syndrome publication-title: Orphanet Journal of Rare Diseases doi: 10.1186/s13023-017-0723-0 – volume: 13 start-page: 724 year: 2014 ident: bib5 article-title: Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition publication-title: Molecular Cancer Therapeutics doi: 10.1158/1535-7163.MCT-13-0749 – volume: 17 start-page: 9 year: 2009 ident: bib35 article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases publication-title: Developmental Cell doi: 10.1016/j.devcel.2009.06.016 – volume: 1866 start-page: 1 year: 2016 ident: bib25 article-title: Cohesin mutations in human Cancer publication-title: Biochimica et Biophysica Acta doi: 10.1016/j.bbcan.2016.05.002 – volume: 28 start-page: 858 year: 2014 ident: bib16 article-title: miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between tgfβ and wnt signaling publication-title: Genes & Development doi: 10.1101/gad.233791.113 – volume: 50 start-page: 6087 year: 1990 ident: bib64 article-title: Ultrastructural and immunocytochemical characterization of an immortalized human breast epithelial cell line, MCF-10 publication-title: Cancer Research – volume: 10 year: 2019 ident: bib43 article-title: A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers publication-title: Nature Communications doi: 10.1038/s41467-019-09659-z – volume: 23 start-page: 8520 year: 2004 ident: bib46 article-title: DKK1, a negative regulator of wnt signaling, is a target of the beta-catenin/TCF pathway publication-title: Oncogene doi: 10.1038/sj.onc.1207892 – volume: 14 start-page: 2988 year: 2016 ident: bib19 article-title: Genome-wide RNAi screen identifies cohesin genes as modifiers of renewal and differentiation in human HSCs publication-title: Cell Reports doi: 10.1016/j.celrep.2016.02.082 – volume: 8 year: 2012 ident: bib8 article-title: Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells publication-title: PLOS Genetics doi: 10.1371/journal.pgen.1002749 – volume: 25 start-page: 337 year: 2014 ident: bib24 article-title: Cohesion promotes nucleolar structure and function publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.e13-07-0377 – volume: 11 start-page: 88 year: 2004 ident: bib56 article-title: Wnt signaling in the stem cell niche publication-title: Current Opinion in Hematology doi: 10.1097/01.moh.0000133649.61121.ec – volume: 8 year: 2018 ident: bib42 article-title: NIPBL+/-Haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states publication-title: Scientific Reports doi: 10.1038/s41598-018-19173-9 – volume: 10 start-page: 491 year: 2020 ident: bib54 article-title: Are wnt/β-Catenin and PI3K/AKT/mTORC1 distinct pathways in colorectal Cancer? publication-title: Cellular and Molecular Gastroenterology and Hepatology doi: 10.1016/j.jcmgh.2020.04.007 – volume-title: The Zebrafish Book. a Guide for the Laboratory Use of Zebrafish (Brachydanio rerio) year: 1995 ident: bib78 – volume: 5 year: 2016 ident: bib76 article-title: In vivo genetic dissection of tumor growth and the warburg effect publication-title: eLife doi: 10.7554/eLife.18126 – volume: 12 start-page: 397 year: 2020 ident: bib2 article-title: BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells publication-title: Journal of Molecular Cell Biology doi: 10.1093/jmcb/mjz114 – volume: 45 start-page: 1293 year: 2013 ident: bib82 article-title: The landscape of somatic mutations in down syndrome–related myeloid disorders publication-title: Nature Genetics doi: 10.1038/ng.2759 – volume: 584 start-page: 98 year: 2020 ident: bib49 article-title: Intracellular pH controls WNT downstream of glycolysis in amniote embryos publication-title: Nature doi: 10.1038/s41586-020-2428-0 – volume: 374 start-page: 2209 year: 2016 ident: bib51 article-title: Genomic classification and prognosis in acute myeloid leukemia publication-title: New England Journal of Medicine doi: 10.1056/NEJMoa1516192 – volume: 22 start-page: R240 year: 2012 ident: bib15 article-title: The ancient and evolving roles of cohesin in gene expression and DNA repair publication-title: Current Biology doi: 10.1016/j.cub.2012.02.046 – volume: 24 start-page: 7005 year: 2015 ident: bib60 article-title: A neural crest origin for cohesinopathy heart defects publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddv402 – volume: 6 year: 2017 ident: bib70 article-title: Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse Cancer contexts publication-title: eLife doi: 10.7554/eLife.26980 – volume: 217 year: 2020 ident: bib28 article-title: Deregulated notch and wnt signaling activates early-stage myeloid regeneration pathways in leukemia publication-title: Journal of Experimental Medicine doi: 10.1084/jem.20190787 – volume: 316 start-page: 1445 year: 2010 ident: bib63 article-title: S-phase and DNA damage activated establishment of sister chromatid cohesion--importance for DNA repair publication-title: Experimental Cell Research doi: 10.1016/j.yexcr.2009.12.018 – volume: 104 start-page: 1332 year: 2019 ident: bib40 article-title: NIPBL: a new player in myeloid cell differentiation publication-title: Haematologica doi: 10.3324/haematol.2018.200899 – volume: 36 start-page: 3573 year: 2017 ident: bib79 article-title: Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins publication-title: The EMBO Journal doi: 10.15252/embj.201798004 – volume: 11 start-page: 132 year: 2020 ident: bib23 article-title: CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism publication-title: Nucleus doi: 10.1080/19491034.2020.1782024 – volume: 8 year: 2020 ident: bib29 article-title: Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos publication-title: Frontiers in Cell and Developmental Biology doi: 10.3389/fcell.2020.617545 – volume: 27 start-page: 3002 year: 2018 ident: bib12 article-title: Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated cornelia de lange syndrome in vitro and in vivo publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddy203 – volume: 36 start-page: 387 year: 2020 ident: bib37 article-title: Cohesin biology: from passive rings to molecular motors publication-title: Trends in Genetics doi: 10.1016/j.tig.2020.03.001 – volume: 13 start-page: 521 year: 2016 ident: bib22 article-title: Growth rate inhibition metrics correct for confounders in measuring sensitivity to Cancer drugs publication-title: Nature Methods doi: 10.1038/nmeth.3853 – volume: 3 year: 2012 ident: bib27 article-title: Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies publication-title: Frontiers in Genetics doi: 10.3389/fgene.2012.00171 – volume: 40 start-page: 342 year: 2017 ident: bib48 article-title: A gradient of glycolytic activity coordinates FGF and wnt signaling during elongation of the body Axis in amniote embryos publication-title: Developmental Cell doi: 10.1016/j.devcel.2017.02.001 – volume: 368 start-page: 1454 year: 2020 ident: bib61 article-title: Cryo-EM structure of the human cohesin-NIPBL-DNA complex publication-title: Science doi: 10.1126/science.abb0981 – volume: 17 year: 2017 ident: bib9 article-title: GRcalculator: an online tool for calculating and mining dose-response data publication-title: BMC Cancer doi: 10.1186/s12885-017-3689-3 – volume: 8 start-page: 37619 year: 2017 ident: bib7 article-title: Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1 publication-title: Oncotarget doi: 10.18632/oncotarget.16838 – volume: 17 start-page: 675 year: 2015 ident: bib38 article-title: Leukemia-Associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.09.017 |
| SSID | ssj0000748819 |
| Score | 2.393049 |
| Snippet | Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| SubjectTerms | Animals Cancer Biology Carcinogenesis - genetics Cell Cycle Proteins - genetics Cell Division Cell Line Chromosomal Proteins, Non-Histone - genetics Chromosomes and Gene Expression cohesin Cohesins DNA damage Drug approval drug screen Genes Genetic aspects Health aspects Humans synthetic lethal Synthetic Lethal Mutations - genetics transcription Transcription (Genetics) wnt signaling Wnt Signaling Pathway - physiology Zebrafish |
| SummonAdditionalLinks | – databaseName: DOAJ - Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fa9cwEA8yEHwR58_qlCgDQahbm0vTPE5xfBXdg264t5Ckl23g-pX1-33Yf7-7tvvSouCLr80Vkuvl7nPp5XNC7DZJlT6gyTXSJofG7ue-RsjJS1ZR-8bqvmfkt6NqcQJfTvXppNUX14QN9MCD4vagIv9ZewtFUhCxtoHZBj1gFSPF3sTel2LeJJnqfbAhwyzscCHPUMjcw68XCd9TMOJGdZMQ1DP1_-mPJwFpXiw5iT6HD8T9ETbKg2G62-IOtg_F3aGR5PUjseBbFpT1y8v18Gu9k_4KZXfdEr6jVyR9nXN6n09dJW3qy7Fpl1wm-fPoWHIVh-eL6Y_FyeGn44-LfOyRkEfKNVZ5DdaXSmkTQQcfjPHWYt1UqaDgFDwBgoIynIQ2VrEwAcqmhhACwyKCZmjVE7HVLlt8JmRsitqDNVHHAGnf-ARFEQBjCU1oNGbi3a3aXBwJxLmPxS9HiQTr2PU6dr2OM7G7Ef498Gb8XewD638jwmTX_QMyATeagPuXCWTiDX89x3QWLdfLnPl117nPP767gwoIzxrCOJl4OwqlJc06-vH6Aa2dGbBmkjszSdpvcTb8-tZIHA9xkVqLy3XnSgo6NahK07KeDkazWZhShAMo9c2EmZnTbOXzkfbivKf7JoBOGFU9_x-qeiHulXxgwPU4Zkdsra7W-JJQ1Sq86jfQDernH8c priority: 102 providerName: Directory of Open Access Journals |
| Title | Cohesin mutations are synthetic lethal with stimulation of WNT signaling |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33284104 https://www.proquest.com/docview/2467843655 https://pubmed.ncbi.nlm.nih.gov/PMC7746233 https://doaj.org/article/468478a941f34ce89b0313a4e6cc727f |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fa9swED66lsFexn7XXRe0URgMnNW2bFlPox0t2VjD6BqWNyHJUhto7TVOYPnvd2c7od76uNfoBNHpTt938ukO4KDwSayNE2Hq0Ml5IQ9DnTse4imZ2VQXMm16Rp6Ns9GEf52m0y1YN-PsFFjfG9pRP6nJ_Hr4-3b1CR0e-etQIBp-dN9m3g0RZ6iW6Q5CkqBWBmcdz2-OZIF2Gsn2fd7fc3qI1BTu__d4voNP_dzJO2B0-gQedyySHbXb_hS2XPkMHrZ9JVfPYUSPLupZyW6W7Zf2mum5Y_WqRLqHUxhu1hXOp0tYhj5-0_XwYpVnP8cXjJI6NL1TfwGT05OLz6Owa5kQWgw9FmHOpY6TJBWWp0YbIbSULi8yHyFWGY38IMKAxztpMxsJw-Mi58YYYknI1JxMXsJ2WZVuF5gtolxzKWxqDfeHQnseRYY7G_PCFKkL4MNabcp29cSprcW1wriCdKwaHatGxwEcbIR_tWU07hc7Jv1vRKj2dfNDNb9UnSspniGi5lryyCfculwaqj-pucusRTbmA3hHu6eoukVJ6TOXelnX6suPc3WUcaS3AilPAO87IV_hv7a6e42Aa6eCWD3J_Z4kup_tDb9dG4miIcpZK121rFWMGJTzJEtxWa9ao9ksLEmQFmAkHIDomVNv5f2RcnbVVP9Gvo6UNdn7H6p6DY9iuj-g9ByxD9uL-dK9QZK1MAN4IKZiADvHJ-Pv54PmqmLQONUf4V8qew |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cohesin+mutations+are+synthetic+lethal+with+stimulation+of+WNT+signaling&rft.jtitle=eLife&rft.au=Chue+Vin+Chin&rft.au=Jisha+Antony&rft.au=Sarada+Ketharnathan&rft.au=Anastasia+Labudina&rft.date=2020-12-07&rft.pub=eLife+Sciences+Publications+Ltd&rft.eissn=2050-084X&rft.volume=9&rft_id=info:doi/10.7554%2FeLife.61405&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_468478a941f34ce89b0313a4e6cc727f |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-084X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-084X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-084X&client=summon |