S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson's Disease Model
Neuronal accumulation of parkin-interacting substrate (PARIS), a transcriptional repressor of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), has been observed in Parkinson's disease (PD). Herein, we showed that PARIS can be S-nitrosylated at cysteine 265 (C265),...
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Published in | Cells (Basel, Switzerland) Vol. 11; no. 22; p. 3682 |
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Abstract | Neuronal accumulation of parkin-interacting substrate (PARIS), a transcriptional repressor of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), has been observed in Parkinson's disease (PD). Herein, we showed that PARIS can be S-nitrosylated at cysteine 265 (C265), and S-nitrosylated PARIS (SNO-PARIS) translocates to the insoluble fraction, leading to the sequestration of PGC-1α into insoluble deposits. The mislocalization of PGC-1α in the insoluble fraction was observed in S-nitrosocysteine-treated PARIS knockout (KO) cells overexpressing PARIS WT but not S-nitrosylation deficient C265S mutant, indicating that insolubility of PGC-1α is SNO-PARIS-dependent. In the sporadic PD model, α-synuclein preformed fibrils (α-syn PFFs)-injected mice, we found an increase in PARIS, SNO-PARIS, and insoluble sequestration of PGC-1α in substantia nigra (SN), resulting in the reduction of mitochondrial DNA copy number and ATP concentration that were restored by N(ω)-nitro-L-arginine methyl ester, a nitric oxide synthase (NOS) inhibitor. To assess the dopaminergic (DA) neuronal toxicity by SNO-PARIS, lentiviral PARIS WT, C265S, and S-nitrosylation mimic C265W was injected into the SN of either PBS- or α-syn PFFs-injected mice. PARIS WT and C265S caused DA neuronal death to a comparable extent, whereas C265W caused more severe DA neuronal loss in PBS-injected mice. Interestingly, there was synergistic DA loss in both lenti-PARIS WT and α-syn PFFs-injected mice, indicating that SNO-PARIS by α-syn PFFs contributes to the DA toxicity in vivo. Moreover, α-syn PFFs-mediated increment of PARIS, SNO-PARIS, DA toxicity, and behavioral deficits were completely nullified in neuronal NOS KO mice, suggesting that modulation of NO can be a therapeutic for α-syn PFFs-mediated neurodegeneration. |
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AbstractList | Neuronal accumulation of parkin-interacting substrate (PARIS), a transcriptional repressor of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), has been observed in Parkinson’s disease (PD). Herein, we showed that PARIS can be S-nitrosylated at cysteine 265 (C265), and S-nitrosylated PARIS (SNO-PARIS) translocates to the insoluble fraction, leading to the sequestration of PGC-1α into insoluble deposits. The mislocalization of PGC-1α in the insoluble fraction was observed in S-nitrosocysteine-treated PARIS knockout (KO) cells overexpressing PARIS WT but not S-nitrosylation deficient C265S mutant, indicating that insolubility of PGC-1α is SNO-PARIS-dependent. In the sporadic PD model, α-synuclein preformed fibrils (α-syn PFFs)-injected mice, we found an increase in PARIS, SNO-PARIS, and insoluble sequestration of PGC-1α in substantia nigra (SN), resulting in the reduction of mitochondrial DNA copy number and ATP concentration that were restored by N(ω)-nitro-L-arginine methyl ester, a nitric oxide synthase (NOS) inhibitor. To assess the dopaminergic (DA) neuronal toxicity by SNO-PARIS, lentiviral PARIS WT, C265S, and S-nitrosylation mimic C265W was injected into the SN of either PBS- or α-syn PFFs-injected mice. PARIS WT and C265S caused DA neuronal death to a comparable extent, whereas C265W caused more severe DA neuronal loss in PBS-injected mice. Interestingly, there was synergistic DA loss in both lenti-PARIS WT and α-syn PFFs-injected mice, indicating that SNO-PARIS by α-syn PFFs contributes to the DA toxicity in vivo. Moreover, α-syn PFFs-mediated increment of PARIS, SNO-PARIS, DA toxicity, and behavioral deficits were completely nullified in neuronal NOS KO mice, suggesting that modulation of NO can be a therapeutic for α-syn PFFs-mediated neurodegeneration. |
Audience | Academic |
Author | Shin, Joo-Ho Kim, Hanna Kwag, Eunsang Kim, Jihye Park, Soo Jeong Lee, Ji-Yeong |
AuthorAffiliation | 2 Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea 3 Samsung Biomedical Research Institute, Samsung Medical Center, Seoul 06351, Republic of Korea 1 Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea |
AuthorAffiliation_xml | – name: 3 Samsung Biomedical Research Institute, Samsung Medical Center, Seoul 06351, Republic of Korea – name: 2 Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – name: 1 Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea |
Author_xml | – sequence: 1 givenname: Hanna orcidid: 0000-0002-3330-5252 surname: Kim fullname: Kim, Hanna organization: Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – sequence: 2 givenname: Ji-Yeong orcidid: 0000-0002-4294-6457 surname: Lee fullname: Lee, Ji-Yeong organization: Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – sequence: 3 givenname: Soo Jeong surname: Park fullname: Park, Soo Jeong organization: Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – sequence: 4 givenname: Eunsang surname: Kwag fullname: Kwag, Eunsang organization: Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – sequence: 5 givenname: Jihye orcidid: 0000-0003-4965-0744 surname: Kim fullname: Kim, Jihye organization: Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea – sequence: 6 givenname: Joo-Ho orcidid: 0000-0002-0499-4589 surname: Shin fullname: Shin, Joo-Ho organization: Samsung Biomedical Research Institute, Samsung Medical Center, Seoul 06351, Republic of Korea |
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Cites_doi | 10.1074/jbc.R113.460261 10.1089/ars.2009.2490 10.1126/scitranslmed.aax8891 10.1074/jbc.M314124200 10.1111/j.1474-9726.2007.00357.x 10.1016/j.celrep.2016.12.090 10.1016/j.bbrc.2021.05.051 10.1523/JNEUROSCI.21-17-06480.2001 10.1093/brain/awz172 10.2174/157015907780866893 10.1126/stke.2001.86.pl1 10.1073/pnas.0403034101 10.1038/s41586-021-03819-2 10.1126/science.1093891 10.1073/pnas.0810595106 10.1078/0940-2993-00301 10.1093/brain/awab061 10.3233/JPD-171248 10.1016/j.pharmthera.2005.05.007 10.1016/j.neuron.2013.05.005 10.3390/ijms22073487 10.3945/ajcn.110.001917 10.1089/ars.2010.3580 10.3389/fphar.2020.00709 10.3233/JPD-171191 10.1016/j.cell.2013.11.009 10.1159/000354307 10.1073/pnas.0705904104 10.1093/cvr/cvn098 10.1016/j.bbadis.2011.10.002 10.1073/pnas.0404161101 10.1073/pnas.1500624112 10.1016/j.cell.2011.02.010 10.1021/tx9600311 10.1126/science.1110135 10.4103/0971-5916.154489 10.1371/journal.pone.0114216 10.1016/j.molcel.2007.02.024 10.1371/journal.pone.0011290 10.1186/1750-1326-6-34 10.1080/10715769900301161 10.1016/j.bbagen.2011.05.008 10.1186/s40035-017-0077-5 10.1002/mds.25945 10.1038/srep44558 10.1242/dmm.008227 |
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Keywords | nitrosative stress PGC-1α PARIS/ZNF746 Parkinson’s disease S-nitrosylation |
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References | Brahmachari (ref_8) 2019; 142 Nakamura (ref_16) 2013; 78 Meng (ref_33) 2011; 6 Karl (ref_21) 2003; 55 Lee (ref_44) 2017; 18 Tan (ref_3) 2009; 11 Chung (ref_13) 2004; 304 Brown (ref_29) 2001; 21 Garnier (ref_40) 2008; 79 Bredt (ref_11) 1999; 31 Khan (ref_38) 2015; 141 Sweeney (ref_5) 2017; 6 Li (ref_47) 2007; 26 Gaven (ref_18) 2014; 91 (ref_27) 2015; 30 Tamir (ref_30) 1996; 9 Dawson (ref_7) 2014; 13 Kim (ref_17) 2021; 563 Choi (ref_34) 2004; 279 Ferreira (ref_25) 2021; 144 Inamdar (ref_2) 2007; 5 Panes (ref_37) 2020; 11 Jo (ref_9) 2021; 13 Breydo (ref_4) 2012; 1822 (ref_42) 2011; 4 Sha (ref_45) 2012; 1820 Polinski (ref_20) 2018; 8 Gould (ref_12) 2013; 288 Tsang (ref_14) 2009; 106 Kumar (ref_35) 2017; 7 Fang (ref_15) 2007; 104 Pringsheim (ref_1) 2014; 29 Anderson (ref_36) 2008; 7 Jumper (ref_24) 2021; 596 Auwerx (ref_39) 2011; 93 Shahani (ref_10) 2011; 14 Ryan (ref_48) 2013; 155 ref_23 ref_22 Brahmachari (ref_26) 2017; 7 ref_41 Yao (ref_32) 2004; 101 Marshall (ref_46) 2004; 101 Shin (ref_6) 2011; 144 Stevens (ref_43) 2015; 112 Jaffrey (ref_19) 2001; 2001 Lipton (ref_31) 2005; 308 Zhang (ref_28) 2006; 109 |
References_xml | – volume: 288 start-page: 26473 year: 2013 ident: ref_12 article-title: Regulation of protein function and signaling by reversible cysteine S-nitrosylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.R113.460261 contributor: fullname: Gould – volume: 11 start-page: 2119 year: 2009 ident: ref_3 article-title: Protein misfolding and aggregation in Parkinson’s disease publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2009.2490 contributor: fullname: Tan – volume: 13 start-page: eaax8891 year: 2021 ident: ref_9 article-title: PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aax8891 contributor: fullname: Jo – volume: 279 start-page: 13256 year: 2004 ident: ref_34 article-title: Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson’s and Alzheimer’s diseases publication-title: J. Biol. Chem. doi: 10.1074/jbc.M314124200 contributor: fullname: Choi – volume: 7 start-page: 101 year: 2008 ident: ref_36 article-title: Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response publication-title: Aging Cell doi: 10.1111/j.1474-9726.2007.00357.x contributor: fullname: Anderson – volume: 18 start-page: 918 year: 2017 ident: ref_44 article-title: PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.12.090 contributor: fullname: Lee – volume: 563 start-page: 98 year: 2021 ident: ref_17 article-title: ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2021.05.051 contributor: fullname: Kim – volume: 21 start-page: 6480 year: 2001 ident: ref_29 article-title: Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-17-06480.2001 contributor: fullname: Brown – volume: 142 start-page: 2380 year: 2019 ident: ref_8 article-title: Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease publication-title: Brain doi: 10.1093/brain/awz172 contributor: fullname: Brahmachari – volume: 5 start-page: 99 year: 2007 ident: ref_2 article-title: Parkinson’s Disease: Genetics and Beyond publication-title: Curr. Neuropharmacol. doi: 10.2174/157015907780866893 contributor: fullname: Inamdar – volume: 2001 start-page: pl1 year: 2001 ident: ref_19 article-title: The biotin switch method for the detection of S-nitrosylated proteins publication-title: Sci. STKE doi: 10.1126/stke.2001.86.pl1 contributor: fullname: Jaffrey – volume: 101 start-page: 8841 year: 2004 ident: ref_46 article-title: S-nitrosylation: Physiological regulation of NF-κB publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0403034101 contributor: fullname: Marshall – volume: 596 start-page: 583 year: 2021 ident: ref_24 article-title: Highly accurate protein structure prediction with AlphaFold publication-title: Nature doi: 10.1038/s41586-021-03819-2 contributor: fullname: Jumper – volume: 304 start-page: 1328 year: 2004 ident: ref_13 article-title: S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function publication-title: Science doi: 10.1126/science.1093891 contributor: fullname: Chung – volume: 106 start-page: 4900 year: 2009 ident: ref_14 article-title: S-nitrosylation of XIAP compromises neuronal survival in Parkinson’s disease publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0810595106 contributor: fullname: Tsang – volume: 55 start-page: 69 year: 2003 ident: ref_21 article-title: Behavioral phenotyping of mice in pharmacological and toxicological research publication-title: Exp. Toxicol. Pathol. doi: 10.1078/0940-2993-00301 contributor: fullname: Karl – volume: 144 start-page: 1853 year: 2021 ident: ref_25 article-title: Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats publication-title: Brain doi: 10.1093/brain/awab061 contributor: fullname: Ferreira – volume: 8 start-page: 303 year: 2018 ident: ref_20 article-title: Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents publication-title: J. Parkinsons Dis. doi: 10.3233/JPD-171248 contributor: fullname: Polinski – volume: 109 start-page: 33 year: 2006 ident: ref_28 article-title: Role of nitric oxide in Parkinson’s disease publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2005.05.007 contributor: fullname: Zhang – volume: 78 start-page: 596 year: 2013 ident: ref_16 article-title: Aberrant protein s-nitrosylation in neurodegenerative diseases publication-title: Neuron doi: 10.1016/j.neuron.2013.05.005 contributor: fullname: Nakamura – ident: ref_41 doi: 10.3390/ijms22073487 – volume: 93 start-page: 884S year: 2011 ident: ref_39 article-title: Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.110.001917 contributor: fullname: Auwerx – volume: 14 start-page: 1493 year: 2011 ident: ref_10 article-title: Nitric oxide signaling and nitrosative stress in neurons: Role for S-nitrosylation publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3580 contributor: fullname: Shahani – volume: 11 start-page: 709 year: 2020 ident: ref_37 article-title: Changes in PGC-1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model publication-title: Front. Pharmacol. doi: 10.3389/fphar.2020.00709 contributor: fullname: Panes – volume: 7 start-page: 589 year: 2017 ident: ref_26 article-title: c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential publication-title: J. Parkinsons Dis. doi: 10.3233/JPD-171191 contributor: fullname: Brahmachari – volume: 155 start-page: 1351 year: 2013 ident: ref_48 article-title: Isogenic human iPSC Parkinson’s model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription publication-title: Cell doi: 10.1016/j.cell.2013.11.009 contributor: fullname: Ryan – volume: 13 start-page: 69 year: 2014 ident: ref_7 article-title: Parkin Plays a Role in Sporadic Parkinson’s Disease publication-title: Neurodegener. Dis. doi: 10.1159/000354307 contributor: fullname: Dawson – volume: 104 start-page: 18742 year: 2007 ident: ref_15 article-title: S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson’s disease publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0705904104 contributor: fullname: Fang – volume: 79 start-page: 208 year: 2008 ident: ref_40 article-title: Transcriptional control of mitochondrial biogenesis: The central role of PGC-1a publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvn098 contributor: fullname: Garnier – volume: 1822 start-page: 261 year: 2012 ident: ref_4 article-title: A-synuclein misfolding and Parkinson’s disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2011.10.002 contributor: fullname: Breydo – volume: 101 start-page: 10810 year: 2004 ident: ref_32 article-title: Nitrosative stress linked to sporadic Parkinson’s disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0404161101 contributor: fullname: Yao – volume: 112 start-page: 11696 year: 2015 ident: ref_43 article-title: Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1500624112 contributor: fullname: Stevens – volume: 144 start-page: 689 year: 2011 ident: ref_6 article-title: PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease publication-title: Cell doi: 10.1016/j.cell.2011.02.010 contributor: fullname: Shin – volume: 9 start-page: 821 year: 1996 ident: ref_30 article-title: DNA damage by nitric oxide publication-title: Chem. Res. Toxicol. doi: 10.1021/tx9600311 contributor: fullname: Tamir – volume: 308 start-page: 1870 year: 2005 ident: ref_31 article-title: Comment on “S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function publication-title: Science doi: 10.1126/science.1110135 contributor: fullname: Lipton – volume: 141 start-page: 13 year: 2015 ident: ref_38 article-title: Mitochondrial disorders: Challenges in diagnosis & treatment publication-title: Indian J. Med. Res. doi: 10.4103/0971-5916.154489 contributor: fullname: Khan – ident: ref_22 doi: 10.1371/journal.pone.0114216 – volume: 26 start-page: 63 year: 2007 ident: ref_47 article-title: Regulation of HIF-1alpha stability through S-nitrosylation publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.02.024 contributor: fullname: Li – ident: ref_23 doi: 10.1371/journal.pone.0011290 – volume: 6 start-page: 34 year: 2011 ident: ref_33 article-title: Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-6-34 contributor: fullname: Meng – volume: 30 start-page: 159 year: 2015 ident: ref_27 article-title: Why is nitric oxide important for our brain? publication-title: Funct. Neurol. – volume: 31 start-page: 577 year: 1999 ident: ref_11 article-title: Endogenous nitric oxide synthesis: Biological functions and pathophysiology publication-title: Free Radic. Res. doi: 10.1080/10715769900301161 contributor: fullname: Bredt – volume: 91 start-page: e51751 year: 2014 ident: ref_18 article-title: Primary Culture of Mouse Dopaminergic Neurons publication-title: J. Vis. Exp. contributor: fullname: Gaven – volume: 1820 start-page: 701 year: 2012 ident: ref_45 article-title: S-nitrosylation in the regulation of gene transcription publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2011.05.008 contributor: fullname: Sha – volume: 6 start-page: 6 year: 2017 ident: ref_5 article-title: Protein misfolding in neurodegenerative diseases: Implications and strategies publication-title: Transl. Neurodegener. doi: 10.1186/s40035-017-0077-5 contributor: fullname: Sweeney – volume: 29 start-page: 1583 year: 2014 ident: ref_1 article-title: The prevalence of Parkinson’s disease: A systematic review and meta-analysis publication-title: Mov. Disord. doi: 10.1002/mds.25945 contributor: fullname: Pringsheim – volume: 7 start-page: 44558 year: 2017 ident: ref_35 article-title: S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation publication-title: Sci. Rep. doi: 10.1038/srep44558 contributor: fullname: Kumar – volume: 4 start-page: 427 year: 2011 ident: ref_42 article-title: Parkin’ control: Regulation of PGC-1α through PARIS in Parkinson’s disease publication-title: Dis. Model. Mech. doi: 10.1242/dmm.008227 |
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SubjectTerms | Alzheimer's disease Animals Antibodies Apoptosis Arginine Copy number Diagnosis Dopamine receptors Dopaminergic Neurons Fibrils Genetic aspects Mice Mice, Knockout Mitochondrial DNA Movement disorders Neurodegeneration Neurodegenerative diseases Neurotoxicity Nitric oxide Nitric-oxide synthase nitrosative stress PARIS/ZNF746 Parkinson Disease Parkinson's disease Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Peroxisome proliferator-activated receptors PGC-1α Proteins Reagents S-nitrosylation Substantia Nigra Synuclein Transcription Factors |
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Title | S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson's Disease Model |
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