ADP receptors of platelets and their inhibition

• Published in: Thrombosis and haemostasis Vol. 86; no. 1; p. 222
• Main Author: Gachet, C
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2001
• Subjects: Animals; Blood Platelets - chemistry; Blood Platelets - physiology; Fibrinolytic Agents - pharmacology; Humans; Platelet Activation - drug effects; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - blood; Receptors, Purinergic P2 - physiology

ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential targets for antithrombotic drugs. Two G-protein coupled P2 receptors contribute to platelet aggregation: the P2Y1 receptor initiates aggregation through mobilisation of calcium stores, while the more recently iden...