Genetic influences on cognitive endophenotypes in schizophrenia

• Published in: Schizophrenia research Vol. 156; no. 1; pp. 71 - 75
• Main Authors: Yeo, Ronald A, Gangestad, Steven W, Walton, Esther, Ehrlich, Stefan, Pommy, Jessica, Turner, Jessica A, Liu, Jingyu, Mayer, Andrew R, Schulz, S. Charles, Ho, Beng-Choon, Bustillo, Juan R, Wassink, Thomas H, Sponheim, Scott R, Morrow, Eric M, Calhoun, Vince D
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Analysis of Variance; Biological and medical sciences; Cognition Disorders - etiology; Cognition Disorders - genetics; Cognitive; Endophenotype; Endophenotypes; Executive function; Female; Follow-Up Studies; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genetics; Humans; Male; Medical sciences; Mutation; Neuropsychological Tests; Principal Component Analysis; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - complications; Schizophrenia - genetics; Young Adult; Schizophrenia; Genetics; Executive function; Cognitive; Mutation; Endophenotype; Psychosis; Human; Cognition; Genetic determinism

Abstract Background Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. Methods The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), an...