Detection and neutralisation of heparin by a fluorescent ruthenium compound

• Published in: Thrombosis and haemostasis Vol. 102; no. 5; p. 859
• Main Authors: Szelke, Helga, Harenberg, Job, Krämer, Roland
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2009
• Subjects: Anticoagulants - antagonists & inhibitors; Anticoagulants - blood; Blood Coagulation Tests; Chromogenic Compounds - analysis; Drug Design; Drug Monitoring - methods; Factor Xa - analysis; Factor Xa Inhibitors; Fiber Optic Technology; Fluorescent Dyes - analysis; Heparin Antagonists - pharmacology; Heparin, Low-Molecular-Weight - antagonists & inhibitors; Heparin, Low-Molecular-Weight - blood; Humans; Molecular Structure; Oligopeptides - analysis; Organometallic Compounds - analysis; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Point-of-Care Systems; Sensitivity and Specificity; Spectrometry, Fluorescence - methods

Heparin and low-molecular-weight heparin (LMWH) are commonly monitored by determination of activated clotting times or chromogenic assays. Despite their wide use, these assays determine the biological activity and not the concentration of the anticoagulants. They may be inaccurate in some circumstan...