Electroactive Oxidized Alginate/Gelatin/MXene (Ti 3 C 2 T x ) Composite Hydrogel with Improved Biocompatibility and Self-Healing Property

Conductive hydrogels (CHs) have shown promising potential applied as wearable or epidermal sensors owing to their mechanical adaptability and similarity to natural tissues. However, it remains a great challenge to develop an integrated hydrogel combining outstanding conductive, self-healing and bioc...

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Published inPolymers Vol. 14; no. 18; p. 3908
Main Authors Zhu, Hui, Dai, Weitao, Wang, Liming, Yao, Cong, Wang, Chenxi, Gu, Bingsong, Li, Dichen, He, Jiankang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.09.2022
MDPI
Subjects
Alginates
Aqueous solutions
Biocompatibility
Cell culture
Electric properties
electrically conductive hydrogel
Electroactivity
Gelatin
Hydrogels
Metal carbides
Multilayers
MXene
MXenes
oxidized alginate
self-healing
Shear strength
Skin
Transition metals
Wound healing
China
United States > US
Japan
Germany
wound healing
electrically conductive hydrogel
oxidized alginate
self-healing
MXene
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Abstract Conductive hydrogels (CHs) have shown promising potential applied as wearable or epidermal sensors owing to their mechanical adaptability and similarity to natural tissues. However, it remains a great challenge to develop an integrated hydrogel combining outstanding conductive, self-healing and biocompatible performances with simple approaches. In this work, we propose a "one-pot" strategy to synthesize multifunctional CHs by incorporating two-dimensional (2D) transition metal carbides/nitrides (MXenes) multi-layer nano-flakes as nanofillers into oxidized alginate and gelatin hydrogels to form the composite CHs with various MXene contents. The presence of MXene with abundant surface groups and outstanding conductivity could improve the mechanical property and electroactivity of the composite hydrogels compared to pure oxidized alginate dialdehyde-gelatin (ADA-GEL). MXene-ADA-GELs kept good self-healing properties due to the dynamic imine linkage of the ADA-GEL network and have a promoting effect on mouse fibroblast (NH3T3s) attachment and spreading, which could be a result of the integration of MXenes with stimulating conductivity and hydrophily surface. This study suggests that the electroactive MXene-ADA-GELs can serve as an appealing candidate for skin wound healing and flexible bio-electronics.
AbstractList Conductive hydrogels (CHs) have shown promising potential applied as wearable or epidermal sensors owing to their mechanical adaptability and similarity to natural tissues. However, it remains a great challenge to develop an integrated hydrogel combining outstanding conductive, self-healing and biocompatible performances with simple approaches. In this work, we propose a “one-pot” strategy to synthesize multifunctional CHs by incorporating two-dimensional (2D) transition metal carbides/nitrides (MXenes) multi-layer nano-flakes as nanofillers into oxidized alginate and gelatin hydrogels to form the composite CHs with various MXene contents. The presence of MXene with abundant surface groups and outstanding conductivity could improve the mechanical property and electroactivity of the composite hydrogels compared to pure oxidized alginate dialdehyde-gelatin (ADA-GEL). MXene-ADA-GELs kept good self-healing properties due to the dynamic imine linkage of the ADA-GEL network and have a promoting effect on mouse fibroblast (NH3T3s) attachment and spreading, which could be a result of the integration of MXenes with stimulating conductivity and hydrophily surface. This study suggests that the electroactive MXene-ADA-GELs can serve as an appealing candidate for skin wound healing and flexible bio-electronics.
Audience Academic
Author Dai, Weitao
Wang, Chenxi
Zhu, Hui
He, Jiankang
Yao, Cong
Wang, Liming
Gu, Bingsong
Li, Dichen
AuthorAffiliation 1 State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710049, China
2 NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University, Xi’an 710049, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36146053$$D View this record in MEDLINE/PubMed
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Issue 18
Keywords wound healing
electrically conductive hydrogel
oxidized alginate
self-healing
MXene
Language English
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Snippet Conductive hydrogels (CHs) have shown promising potential applied as wearable or epidermal sensors owing to their mechanical adaptability and similarity to...
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StartPage 3908
SubjectTerms Alginates
Aqueous solutions
Biocompatibility
Cell culture
Electric properties
electrically conductive hydrogel
Electroactivity
Gelatin
Hydrogels
Metal carbides
Multilayers
MXene
MXenes
oxidized alginate
self-healing
Shear strength
Skin
Transition metals
Wound healing
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Title Electroactive Oxidized Alginate/Gelatin/MXene (Ti 3 C 2 T x ) Composite Hydrogel with Improved Biocompatibility and Self-Healing Property
URI https://www.ncbi.nlm.nih.gov/pubmed/36146053
https://www.proquest.com/docview/2716600036
https://search.proquest.com/docview/2717687336
https://pubmed.ncbi.nlm.nih.gov/PMC9506128
https://doaj.org/article/4124f57cd42749faad3cc402713fd989
Volume 14
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