Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution

• Published in: Journal of hematology and oncology Vol. 18; no. 1; pp. 66 - 19
• Main Authors: Liu, Chunliang, Wang, Xiang, Liu, Erdong, Zong, Yali, Yu, Wenlong, Jiang, Youhai, Chen, Jianan, Gu, Mingye, Meng, Zhengyuan, Li, Jingfeng, Liu, Yang, Zhang, Yongjie, Tang, Jing, Wang, Hongyang, Fu, Jing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.06.2025; BioMed Central; BMC
• Subjects: Analysis; Animal models; Animals; B cells; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - pathology; Bile ducts; Biological response modifiers; Cancer; Cell cycle; Cholangiocarcinoma; Cholangiocarcinoma - genetics; Cholangiocarcinoma - pathology; Clinical trials; DNA microarrays; Drug resistance; Epithelial cells; Genes; Genomes; Genomics; Humans; Immunotherapy; Inflammation; Interferon; Malignancy; Medical prognosis; Mice; Microenvironments; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Oncology; Organoids; Patients; Precision medicine; Progenitor cells; RNA; RNA sequencing; Senescence; Single-Cell Analysis - methods; Stem Cell Niche; Stem cells; Therapeutic targets; Transcriptomics; Tumor Microenvironment; Tumorigenesis

Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy, primarily comprising intrahepatic (iCCA) and extrahepatic (eCCA) subtypes. Reconciling the variability between iCCAs and eCCAs in clinical trials remains a challenge, largely due to the inadequate understanding of their shared and subtyp...