Extracellular purines are biomarkers of neutrophilic airway inflammation

• Published in: The European respiratory journal Vol. 31; no. 5; pp. 949 - 956
• Main Authors: Esther, C. R., Jr, Alexis, N. E, Clas, M. L, Lazarowski, E. R, Donaldson, S. H, Pedrosa Ribeiro, C. M, Moore, C. G, Davis, S. D, Boucher, R. C
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.05.2008; Maney
• Subjects: Adenosine Monophosphate - analysis; Adenosine Triphosphate - analysis; Adolescent; Adult; Biological and medical sciences; Biomarkers - analysis; Breath Tests - methods; Bronchoalveolar Lavage Fluid - immunology; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis - diagnosis; Cystic Fibrosis - immunology; Errors of metabolism; Female; Humans; Inflammation - immunology; Inflammation Mediators - analysis; Leukocyte Count; Lung - immunology; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Neutrophils - immunology; Pneumology; Sputum - immunology; Expired air; Biomarker; Respiratory disease; purinergic signalling; Biological marker; Metabolic diseases; Cystic fibrosis; Inflammation; Extracellular; Genetic disease; Bronchoalveolar lavage; exhaled breath condensate; bronchoalveolar lavage fluid; Digestive diseases; Purine; Respiration; Pancreatic disease; Pneumology

Purinergic signalling regulates airway defence mechanisms, suggesting that extracellular purines could serve as airway inflammation biomarkers in cystic fibrosis (CF). The purines adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and adenosine were measured in...