The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans - Al Rifai, Omar; Julien, Catherine; Lacombe, Julie; Faubert, Denis; Lira-Navarrete, Erandi; Narimatsu, Yoshiki; Clausen, Henrik; Ferron, Mathieu (eLife, 2020)
Keywords: Animal experimentation; Animals; Biochemistry and Chemical Biology; bone; Bone and Bones - metabolism; Glycosylation; Half-Life; Hormones; Hormones - metabolism; Humans; Insulin Resistance - physiology; Medicine; Mice; o-linked glycosylation; Osteoblasts - metabolism; osteocalcin; Osteocalcin - metabolism; Physiological aspects; plasmin; Protein Processing, Post-Translational - physiology; Tyrosine; mouse; chemical biology; plasmin; biochemistry; glycosylation; osteocalcin; bone; medicine; half-life; human; o-linked glycosylation