Targeting Transcription Factors ATF5, CEBPB and CEBPD with Cell-Penetrating Peptides to Treat Brain and Other Cancers

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 4; p. 581
• Main Authors: Greene, Lloyd A., Zhou, Qing, Siegelin, Markus D., Angelastro, James M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Activating Transcription Factors - metabolism; ATF5; Brain - metabolism; Brain cancer; Brain tumors; Cancer therapies; Care and treatment; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CEBPB; CEBPD; Cell-Penetrating Peptides - pharmacology; Clinical trials; Drug delivery; Drug Development; Gene expression; glioblastoma; Health aspects; Humans; Kinases; Leucine zipper proteins; Neoplasms; Peptides; Proteins; Review; Solid tumors; transcription factor; Transcription factors; Tumors; United States; cell-penetrating; transcription factor; CEBPB; glioblastoma; CEBPD; dominant-negative; brain cancer; ATF5; decoy; drug

Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD...