Extension of in vivo half-life of biologically active molecules by XTEN protein polymers

• Published in: Journal of controlled release Vol. 240; pp. 52 - 66
• Main Authors: Podust, Vladimir N., Balan, Sibu, Sim, Bee-Cheng, Coyle, Michael P., Ernst, Ulrich, Peters, Robert T., Schellenberger, Volker
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.10.2016
• Subjects: Animals; biodegradability; Biological Products - chemistry; Biological Products - pharmacokinetics; Biotherapeutics; Chemical conjugation; chromatography; Clinical Trials as Topic - methods; Drug Discovery - methods; Drug Discovery - trends; drugs; Escherichia coli; Genetic fusion; Half-Life; Half-life extension; Humans; hydrodynamics; hydrophilicity; Peptides; polymers; Polymers - chemistry; Polymers - pharmacokinetics; polypeptides; Protein Structure, Secondary; proteins; Proteins - chemistry; Proteins - pharmacokinetics; therapeutics; XTEN protein polymer; XTEN protein polymer; Biotherapeutics; Chemical conjugation; Peptides; Half-life extension; Genetic fusion

XTEN™ is a class of unstructured hydrophilic, biodegradable protein polymers designed to increase the half-lives of therapeutic peptides and proteins. XTEN polymers and XTEN fusion proteins are typically expressed in Escherichia coli and purified by conventional protein chromatography as monodispers...