Extension of in vivo half-life of biologically active molecules by XTEN protein polymers - Podust, Vladimir N.; Balan, Sibu; Sim, Bee-Cheng; Coyle, Michael P.; Ernst, Ulrich; Peters, Robert T.; Schellenberger, Volker (Journal of controlled release, 2016)
Keywords: Animals; biodegradability; Biological Products - chemistry; Biological Products - pharmacokinetics; Biotherapeutics; Chemical conjugation; chromatography; Clinical Trials as Topic - methods; Drug Discovery - methods; Drug Discovery - trends; drugs; Escherichia coli; Genetic fusion; Half-Life; Half-life extension; Humans; hydrodynamics; hydrophilicity; Peptides; polymers; Polymers - chemistry; Polymers - pharmacokinetics; polypeptides; Protein Structure, Secondary; proteins; Proteins - chemistry; Proteins - pharmacokinetics; therapeutics; XTEN protein polymer; XTEN protein polymer; Biotherapeutics; Chemical conjugation; Peptides; Half-life extension; Genetic fusion