Correlation between Neutrophil Extracellular Traps (NETs) Expression and Primary Graft Dysfunction Following Human Lung Transplantation

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 21; p. 3420
• Main Authors: Bonneau, Steven, Landry, Caroline, Bégin, Stéphanie, Adam, Damien, Villeneuve, Louis, Clavet-Lanthier, Marie-Élaine, Dasilva, Ariane, Charles, Elcha, Dumont, Benjamin L., Neagoe, Paul-Eduard, Brochiero, Emmanuelle, Menaouar, Ahmed, Nasir, Basil, Stevens, Louis-Mathieu, Ferraro, Pasquale, Noiseux, Nicolas, Sirois, Martin G.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.10.2022; MDPI
• Subjects: Alveoli; Biomarkers; Biomarkers - metabolism; Biopsy; C-reactive protein; Cell-Free Nucleic Acids; Cytokines; Deoxyribonucleic acid; DNA; DNA - metabolism; Edema; Enzyme-linked immunosorbent assay; Extracellular Traps - metabolism; Extracorporeal membrane oxygenation; Filaments; Graft versus host reaction; Health aspects; Histology; Humans; Hypoxemia; Immunofluorescence; Immunohistochemistry; Inflammation; Interleukin 6; Interleukin 8; Interleukin-6 - metabolism; Interleukin-8 - metabolism; Ischemia; Leukocytes (neutrophilic); lung transplant; Lung transplantation; Lung Transplantation - adverse effects; Lung transplants; Lungs; Medical records; Mortality; NETs; Neutrophils; Occlusion; Peroxidase; primary graft dysfunction; Primary Graft Dysfunction - metabolism; Pulmonary arteries; Risk factors; Surgery; Transplantation; Canada; United States > US; NETs; cytokines; lung transplant; neutrophils; primary graft dysfunction

Primary graft dysfunction (PGD) is characterized by alveolar epithelial and vascular endothelial damage and inflammation, lung edema and hypoxemia. Up to one-third of recipients develop the most severe form of PGD (Grade 3; PGD3). Animal studies suggest that neutrophils contribute to the inflammator...