Anthracycline‑induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review)

• Published in: Molecular and clinical oncology Vol. 11; no. 1; pp. 15 - 23
• Main Authors: Cai, Fengfeng, Luis, Manuel, Lin, Xiaoyan, Wang, Minghong, Cai, Lu, Cen, Chunmei, Biskup, Ewelina
• Format: Journal Article
• Language: English
• Published: England Spandidos Publications 01.07.2019; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Anopheles; Anthracyclines; Apoptosis; Breast cancer; Cancer therapies; Cancer treatment; Cardiac arrhythmia; Cardiology; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Cell cycle; Chemotherapy; Coronary vessels; Cyclin-dependent kinases; Development and progression; Disease prevention; Drug therapy; Drugs; Endocrine therapy; Etiology (Medicine); Free radicals; Gene expression; Health; Health aspects; Health screening; Heart failure; Metabolism; Metabolites; Oncology; Oxidative stress; Patients; Radiation therapy; Review; Thrombosis; Tumors; Vincristine; Women; Women's health; Womens health; United States > US; treatment; cardiotoxicity; risk factors; breast cancer; anthracyclines; doxorubicin; prevention

Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data suppor...