Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 13; no. 2; pp. 1385 - 1402
• Main Authors: Le Gall, Laura, Duddy, William J., Martinat, Cecile, Mariot, Virginie, Connolly, Owen, Milla, Vanessa, Anakor, Ekene, Ouandaogo, Zamalou G., Millecamps, Stephanie, Lainé, Jeanne, Vijayakumar, Udaya Geetha, Knoblach, Susan, Raoul, Cedric, Lucas, Olivier, Loeffler, Jean Philippe, Bede, Peter, Behin, Anthony, Blasco, Helene, Bruneteau, Gaelle, Del Mar Amador, Maria, Devos, David, Henriques, Alexandre, Hesters, Adele, Lacomblez, Lucette, Laforet, Pascal, Langlet, Timothee, Leblanc, Pascal, Le Forestier, Nadine, Maisonobe, Thierry, Meininger, Vincent, Robelin, Laura, Salachas, Francois, Stojkovic, Tanya, Querin, Giorgia, Dumonceaux, Julie, Butler Browne, Gillian, González De Aguilar, Jose‐Luis, Duguez, Stephanie, Pradat, Pierre Francois
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.04.2022; Wiley Open Access/Springer Verlag; John Wiley and Sons Inc; Wiley
• Subjects: Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Biopsy; Cell culture; Cell–cell communication; Disease; Extracellular vesicles; Humans; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Life Sciences; MND; Motor Neurons - metabolism; Muscle Cells - metabolism; Mutation; Neurotoxicity; Original; Proteomics; Secreted vesicles; sporadic ALS; sporadic ALS; MND; Secreted vesicles; Cell-cell communication

Background The cause of the motor neuron (MN) death that drives terminal pathology in amyotrophic lateral sclerosis (ALS) remains unknown, and it is thought that the cellular environment of the MN may play a key role in MN survival. Several lines of evidence implicate vesicles in ALS, including that...