Structural MRI biomarkers for preclinical and mild Alzheimer's disease

• Published in: Human brain mapping Vol. 30; no. 10; pp. 3238 - 3253
• Main Authors: Fennema-Notestine, Christine, Hagler Jr, Donald J., McEvoy, Linda K., Fleisher, Adam S., Wu, Elaine H., Karow, David S., Dale, Anders M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2009; Wiley-Liss
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - pathology; Alzheimer's disease; Biological and medical sciences; brain imaging; Case-Control Studies; Cerebral Cortex - pathology; Cognition Disorders - etiology; Cognition Disorders - pathology; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical sciences; Mental Status Schedule; Middle Aged; mild cognitive impairment; morphometry; MRI; Nervous system; Neurology; Neuropsychological Tests; Radiodiagnosis. Nmr imagery. Nmr spectrometry; brain imaging; Nervous system diseases; Radiodiagnosis; Alzheimer disease; MRI; Central nervous system; Asymptomatic; Nuclear magnetic resonance imaging; Cerebral disorder; Encephalon; Central nervous system disease; Degenerative disease; mild cognitive impairment; Morphometry; Alzheimer's disease

Noninvasive MRI biomarkers for Alzheimer's disease (AD) may enable earlier clinical diagnosis and the monitoring of therapeutic effectiveness. To assess potential neuroimaging biomarkers, the Alzheimer's Disease Neuroimaging Initiative is following normal controls (NC) and individuals with...