Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1–Expressed CD8 + T Cells in Multiple Sclerosis

• Published in: Neurology : neuroimmunology & neuroinflammation Vol. 9; no. 4
• Main Authors: Koto, Shusuke, Chihara, Norio, Akatani, Ritsu, Nakano, Hiroko, Hara, Atsushi, Sekiguchi, Kenji, Matsumoto, Riki, Toda, Tatsushi
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.07.2022
• Subjects: Apoptosis; Case-Control Studies; CD8-Positive T-Lymphocytes - metabolism; Humans; Interleukin-10 - metabolism; Multiple Sclerosis; Programmed Cell Death 1 Receptor - metabolism; Proto-Oncogene Proteins c-maf - metabolism

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. CD8 T cells are prominently found at inflammatory sites. Recent advances in understanding checkpoint molecules, including programmed cell death 1 (PD-1), expressed on CD8 T cells, highlight the immune regulatory roles of th...