Using optical coherence tomography to evaluate skin sun damage and precancer
Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods OCT images were acquired of 112 patients at 2 sun protected and 2 s...
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| Published in | Lasers in surgery and medicine Vol. 39; no. 9; pp. 687 - 695 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.10.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Background and Objectives
Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK).
Study Design/Materials and Methods
OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed.
Results
Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P<0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P<0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity.
Conclusion
OCT has the potential to guide biopsies and provide non‐invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Lesers Surg. Med. 39:687–695, 2007. © 2007 Wiley‐Liss, Inc. |
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| AbstractList | Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK).
OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed.
Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P<0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P<0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity.
OCT has the potential to guide biopsies and provide non-invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P<0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P<0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion OCT has the potential to guide biopsies and provide non-invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Lesers Surg. Med. 39:687-695, 2007. Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P<0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P<0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion OCT has the potential to guide biopsies and provide non‐invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Lesers Surg. Med. 39:687–695, 2007. © 2007 Wiley‐Liss, Inc. |
| Author | Saboda, Kathylynn Slayton, Lisa D. Barton, Jennifer K. Warneke, James A. Korde, Vrushali R. Alberts, David S. Salasche, Stuart J. Ranger-Moore, James Xu, Wei Bonnema, Garret T. Krishnamurthy, Chetankumar |
| AuthorAffiliation | 1 College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721 2 Department of Systems and Industrial Engineering, The University of Arizona, Tucson, Arizona 85721 3 Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 4 Division of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721 |
| AuthorAffiliation_xml | – name: 2 Department of Systems and Industrial Engineering, The University of Arizona, Tucson, Arizona 85721 – name: 1 College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721 – name: 3 Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – name: 4 Division of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721 |
| Author_xml | – sequence: 1 givenname: Vrushali R. surname: Korde fullname: Korde, Vrushali R. organization: College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721 – sequence: 2 givenname: Garret T. surname: Bonnema fullname: Bonnema, Garret T. organization: College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721 – sequence: 3 givenname: Wei surname: Xu fullname: Xu, Wei organization: Department of Systems and Industrial Engineering, The University of Arizona, Tucson, Arizona 85721 – sequence: 4 givenname: Chetankumar surname: Krishnamurthy fullname: Krishnamurthy, Chetankumar organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 5 givenname: James surname: Ranger-Moore fullname: Ranger-Moore, James organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 6 givenname: Kathylynn surname: Saboda fullname: Saboda, Kathylynn organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 7 givenname: Lisa D. surname: Slayton fullname: Slayton, Lisa D. organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 8 givenname: Stuart J. surname: Salasche fullname: Salasche, Stuart J. organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 9 givenname: James A. surname: Warneke fullname: Warneke, James A. organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 10 givenname: David S. surname: Alberts fullname: Alberts, David S. organization: Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85721 – sequence: 11 givenname: Jennifer K. surname: Barton fullname: Barton, Jennifer K. email: barton@u.arizona.edu organization: College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17960754$$D View this record in MEDLINE/PubMed |
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| References_xml | – volume: 42 start-page: S4 year: 2000 end-page: S7 article-title: Epidemiology of actinic keratoses and squamous cell carcinoma publication-title: J Am Acad Dermatol – volume: 8 start-page: 570 year: 2003 end-page: 575 article-title: Texture, analysis of optical coherence tomography images: Feasibility for tissue classification publication-title: J Biomed Opt – volume: 43 start-page: 42 year: 2000 end-page: 48 article-title: Confocal laser microscopic imaging of actinic keratoses in vivo: A preliminary report publication-title: J Am Acad Dermatol – volume: 40 start-page: 85 year: 2005 end-page: 94 article-title: Applications of optical coherence tomography in dermatology publication-title: J Dermatol Sci – volume: 36 start-page: 1292 year: 2000 end-page: 1297 article-title: The state‐of‐the‐art in chemoprevention of skin cancer publication-title: Eur J Cancer – volume: 9 start-page: 274 year: 2004 end-page: 281 article-title: Characterization of age‐related effects in human skin: A comparative study that applies confocal laser scanning microscopy and optical coherence tomography publication-title: J Biomed Opt – volume: 42 start-page: S11 year: 2000 end-page: S17 article-title: Histopathology of incipient intraepidermal squamous cell carcinoma (“Actinic Keratosis”) publication-title: J Am Acad Dermatol – volume: 295 start-page: 50 year: 2003 end-page: 55 article-title: Optical coherence tomography in contact dermatitis and psoriasis publication-title: Arch Dermatol Res – volume: 6 start-page: 6 year: 2000 end-page: 16 article-title: optical coherence tomography imaging of human skin: Norm and pathology publication-title: Skin Res Technol – volume: 104 start-page: 946 year: 1995 end-page: 952 article-title: confocal scanning laser microscopy of human skin—Melanin provides strong contrast publication-title: J Invest Dermatol – volume: 10 start-page: 169 year: 2004 end-page: 173 article-title: Histomorphologic correlation with routine histology and optical coherence tomography publication-title: Skin Res Technol – volume: 2 start-page: 525 year: 2003 end-page: 535 article-title: Investigating sun‐damaged skin and actinic keratosis with optical coherence tomography: A pilot study publication-title: Technol Cancer Res Treat – volume: 37 start-page: 958 year: 1997 end-page: 963 article-title: Optical coherence tomography of the human skin publication-title: J Am Acad Dermatol – volume: 30 start-page: 79 year: 2005 end-page: 82 article-title: UVA1 and UVB irradiated skin investigated by optical coherence tomography : A preliminary study publication-title: Clin Exp Dermatol – volume: 23 start-page: 322 year: 1984 end-page: 329 article-title: studies of the evolution of physical‐properties of the human‐skin with age publication-title: Int J Dermatol – ident: e_1_2_1_6_2 doi: 10.1016/j.jdermsci.2005.07.006 – ident: e_1_2_1_13_2 doi: 10.1117/1.1645795 – ident: e_1_2_1_16_2 doi: 10.1067/mjd.2000.105565 – ident: e_1_2_1_11_2 doi: 10.1117/1.1577575 – ident: e_1_2_1_3_2 doi: 10.1067/mjd.2000.103344 – ident: e_1_2_1_15_2 doi: 10.1111/1523-1747.ep12606215 – ident: e_1_2_1_10_2 doi: 10.1111/j.1365-2230.2004.01690.x – ident: e_1_2_1_12_2 doi: 10.1034/j.1600-0846.2000.006001006.x – ident: e_1_2_1_4_2 doi: 10.1067/mjd.2000.103342 – ident: e_1_2_1_9_2 doi: 10.1177/153303460300200605 – ident: e_1_2_1_8_2 doi: 10.1111/j.1600-0846.2004.00038.x – ident: e_1_2_1_2_2 doi: 10.1016/S0959-8049(00)00108-8 – ident: e_1_2_1_7_2 doi: 10.1007/s00403-003-0390-y – ident: e_1_2_1_5_2 doi: 10.1016/S0190-9622(97)70072-0 – ident: e_1_2_1_14_2 doi: 10.1111/j.1365-4362.1984.tb04061.x |
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| Snippet | Background and Objectives
Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the... Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic... Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the... |
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| SubjectTerms | actinic keratosis Adult Aged Aged, 80 and over Biopsy Diagnosis, Differential Humans image processing imaging Keratosis - diagnosis Middle Aged Precancerous Conditions - diagnosis Sensitivity and Specificity Skin - radiation effects skin cancer Sunlight Tomography, Optical Coherence - methods Ultraviolet Rays - adverse effects |
| Title | Using optical coherence tomography to evaluate skin sun damage and precancer |
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