Recovery from cortical blindness with mepivacaïne

We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life...

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Published inAnnals of clinical and translational neurology Vol. 6; no. 8; pp. 1541 - 1545
Main Authors Cohen, Laurent, Ponchel, Amélie, Kas, Aurélie, Ströer, Sébastian, Del Cul, Antoine, Guérineau de Lamérie, Guillaume, El Hachem, Randa, Crépin, Piirika, Morin, Alexandre
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.08.2019
Wiley
John Wiley and Sons Inc
Subjects
Anesthesia
Blindness, Cortical - drug therapy
Blindness, Cortical - etiology
Blindness, Cortical - physiopathology
Brain
Brain - pathology
Brief Communication
Brief Communications
Cerebral Cortex - pathology
Cognition & reasoning
Humans
Life Sciences
Magnetic Resonance Imaging
Male
Medication
Mepivacaine - therapeutic use
Metabolism
Middle Aged
Neurobiology
Neurons and Cognition
Paroxetine - therapeutic use
Pharmaceutical sciences
Stroke
Stroke - complications
Stroke - physiopathology
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Abstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.
AbstractList We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.
We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.
Abstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.
Author El Hachem, Randa
Guérineau de Lamérie, Guillaume
Ponchel, Amélie
Crépin, Piirika
Del Cul, Antoine
Morin, Alexandre
Ströer, Sébastian
Kas, Aurélie
Cohen, Laurent
AuthorAffiliation 6 Département d'information médicale Centre hospitalier Guillaume Régnier 35703 Rennes France
8 Centre Medico Psycho Pédagogique 11100 Narbonne France
1 Institut du Cerveau et de la Moelle épinière, ICM Sorbonne Université Inserm U 1127, CNRS UMR 7225 F‐75013 Paris France
5 Service de psychiatrie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris France
3 Service de médecine nucléaire Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris France
4 Service de neuroradiologie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris France
7 Service d’anesthésie Centre Hospitalier 11100 Narbonne France
2 Département de neurologie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris France
AuthorAffiliation_xml – name: 3 Service de médecine nucléaire Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris France
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CitedBy_id crossref_primary_10_1016_j_ijscr_2023_108753
crossref_primary_10_1080_13102818_2020_1837009
crossref_primary_10_1080_10749357_2024_2413269
crossref_primary_10_1097_WCO_0000000000000884
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Snippet We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field...
Abstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right...
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SubjectTerms Anesthesia
Blindness, Cortical - drug therapy
Blindness, Cortical - etiology
Blindness, Cortical - physiopathology
Brain
Brain - pathology
Brief Communication
Brief Communications
Cerebral Cortex - pathology
Cognition & reasoning
Humans
Life Sciences
Magnetic Resonance Imaging
Male
Medication
Mepivacaine - therapeutic use
Metabolism
Middle Aged
Neurobiology
Neurons and Cognition
Paroxetine - therapeutic use
Pharmaceutical sciences
Stroke
Stroke - complications
Stroke - physiopathology
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Title Recovery from cortical blindness with mepivacaïne
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Facn3.50832
https://www.ncbi.nlm.nih.gov/pubmed/31402624
https://www.proquest.com/docview/2271603341
https://www.proquest.com/docview/2272216691
https://hal.sorbonne-universite.fr/hal-02279804
https://pubmed.ncbi.nlm.nih.gov/PMC6689678
https://doaj.org/article/fc7b11412b9b42578a008502abb23947
Volume 6
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