The complex genetic architecture of Alzheimer's disease: novel insights and future directions

• Published in: EBioMedicine Vol. 90; p. 104511
• Main Authors: Andrews, Shea J., Renton, Alan E., Fulton-Howard, Brian, Podlesny-Drabiniok, Anna, Marcora, Edoardo, Goate, Alison M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2023; Elsevier
• Subjects: Advanced Basic Science; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - genetics; Biomarkers - cerebrospinal fluid; Genetic Predisposition to Disease; Genome-wide association study; Genome-Wide Association Study - methods; Humans; Internal Medicine; Polymorphism, Single Nucleotide; Review; Genome-wide association study; Alzheimer's disease; Review

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge...