Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors

• Published in: Aging cell Vol. 14; no. 3; pp. 421 - 432
• Main Authors: Metcalf, Talibah U., Cubas, Rafael A., Ghneim, Khader, Cartwright, Michael J., Grevenynghe, Julien Van, Richner, Justin M., Olagnier, David P., Wilkinson, Peter A., Cameron, Mark J., Park, Byung S., Hiscott, John B., Diamond, Michael S., Wertheimer, Anne M., Nikolich‐Zugich, Janko, Haddad, Elias K.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2015; BlackWell Publishing Ltd
• Subjects: Adaptive Immunity - genetics; Adult; Aged; Aged, 80 and over; Aging; B cells; B-Lymphocytes - immunology; Biological response modifiers; Chemokines - metabolism; Comparative analysis; Cytokines - metabolism; Dendritic cells; Dendritic Cells - immunology; Disease susceptibility; Health aspects; Humans; Immune response; Immune system; Immunity, Innate - immunology; immunosenescence; Immunotherapy; innate immune agonists; innate immunity; Interferon; interferon signaling; Leukocytes, Mononuclear - metabolism; Lymphocyte Activation - genetics; Lymphocytes; Monocytes - immunology; Original; pattern recognition receptors; peripheral blood mononuclear cells; T cells; T-Lymphocytes - immunology; Vaccines; Young Adult; pattern recognition receptors; peripheral blood mononuclear cells; immunosenescence; interferon signaling; innate immunity; innate immune agonists

Summary Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity re...