Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non‐small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study - Ekman, Simon; Cselényi, Zsolt; Varrone, Andrea; Jucaite, Aurelija; Martin, Heather; Schou, Magnus; Johnström, Peter; Laus, Gianluca; Lewensohn, Rolf; Brown, Andrew P.; Aart, Jasper; Vishwanathan, Karthick; et al. (Clinical and translational science, 2023)
Keywords: Brain; Brain cancer; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - drug therapy; Brain Neoplasms - genetics; Brain tumors; Cancer therapies; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Central nervous system; Clinical medicine; Clinical trials; Drug dosages; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - genetics; Humans; Lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Magnetic Resonance Imaging; Metastases; Metastasis; Mutation; Nervous system; Neuroimaging; Non-small cell lung carcinoma; Patients; Positron emission tomography; Protein Kinase Inhibitors; Protein-tyrosine kinase; Radioactivity; Small cell lung carcinoma; Solid tumors; Targeted cancer therapy; Tomography; Tumors; Volumetric analysis; Sweden