Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 29; no. 1; p. 123
• Main Authors: Khuanjing, Thawatchai, Maneechote, Chayodom, Ongnok, Benjamin, Prathumsap, Nanthip, Arinno, Apiwan, Chunchai, Titikorn, Arunsak, Busarin, Chattipakorn, Siriporn C., Chattipakorn, Nipon
• Format: Journal Article
• Language: English
• Published: London BioMed Central 11.09.2023; BMC
• Subjects: Acetylcholinesterase inhibitor; Cardiotoxicity; Mitochondria; Programmed cell death pathways; Trastuzumab

Abstract Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as potential mechanisms underlying TIC, the...