Involvement of long noncoding RNAs in diseases affecting the central nervous system

• Published in: RNA biology Vol. 9; no. 6; pp. 860 - 870
• Main Authors: Pastori, Chiara, Wahlestedt, Claes
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.06.2012; Landes Bioscience
• Subjects: Animals; Binding; Biology; biomarkers; Bioscience; brain cancer; Brain Neoplasms - genetics; Calcium; Cancer; Cell; central nervous system; Chromosome Disorders - genetics; Cycle; DNA; epigenetics; etiology; Gene Expression; Gene Expression Regulation; genes; genetic analysis; Genomic Imprinting; human diseases; Humans; Landes; long noncoding RNAs; nervous system diseases; Neurodegenerative Diseases - genetics; neurological disorders; non-coding RNA; nucleotide sequences; Organogenesis; Proteins; Review; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA-binding proteins; RNA-targeting therapies; transcription (genetics); translation (genetics)

DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies...