The Jak/STAT pathway: A focus on pain in rheumatoid arthritis

• Published in: Seminars in arthritis and rheumatism Vol. 51; no. 1; pp. 278 - 284
• Main Authors: Simon, Lee S., Taylor, Peter C., Choy, Ernest H., Sebba, Anthony, Quebe, Amanda, Knopp, Kelly L., Porreca, Frank
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021
• Subjects: Cytokines; Inflammation; Janus kinases; Pain; Rheumatoid arthritis; STAT; IL; Cytokines; VEGF; TYK; Janus kinases; Inflammation; TNF; RA; IFN; STAT; R; Pain; GM-CSF; Jak; Rheumatoid arthritis; DRG; gp130
• ISSN: 0049-0172; 1532-866X; 1532-866X
• DOI: 10.1016/j.semarthrit.2020.10.008

Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase 3 clinical trial showed that patients with RA who were treated with a Janus kinase 1 (Jak1) and Janus kinase 2 (J...