The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review

• Published in: Antioxidants Vol. 8; no. 5; p. 121
• Main Authors: Kim, Yonghee, Park, Jinhong, Choi, Yoon Kyung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2019; MDPI
• Subjects: Adenosine triphosphate; Alzheimer's disease; Angiogenesis; Antioxidants; Astrocytes; Biosynthesis; BK channel; Brain; Calcium homeostasis; Central nervous system; Energy storage; Enzymes; Gene expression; Heme; heme oxygenase metabolites; Homeostasis; Kinases; Metabolites; Mitochondria; Molecular modelling; Morphology; Movement disorders; Nervous system; Neurodegenerative diseases; Neurogenesis; Neuromodulation; Neurons; oxidative/nitrosative stress; Oxygenase; Parkinson's disease; Phosphorylation; Physiology; Potassium; Potassium conductance; Proteins; Review; Synuclein; Vascular endothelial growth factor; Vascular system; β-Amyloid; BK channel; astrocytes; oxidative/nitrosative stress; heme oxygenase metabolites

Astrocytes outnumber neurons in the human brain, and they play a key role in numerous functions within the central nervous system (CNS), including glutamate, ion (i.e., Ca2+, K+) and water homeostasis, defense against oxidative/nitrosative stress, energy storage, mitochondria biogenesis, scar format...