ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion

• Published in: European journal of histochemistry Vol. 62; no. 2; p. 2877
• Main Authors: Nishida, Kentaro, Nomura, Yuka, Kawamori, Kanako, Ohishi, Akihiro, Nagasawa, Kazuki
• Format: Journal Article
• Language: English
• Published: Italy PAGEPress Publications 09.04.2018; PAGEPress Scientific Publications, Pavia, Italy; PAGEPress Publications, Pavia, Italy
• Subjects: Acid phosphatase; Adenine; Adenosine; Adenosine Triphosphate - metabolism; AMP; Animals; ATP, ectoenzyme; clearance system; Dorsal root ganglia; dorsal root ganglion; Ecto-nucleotide pyrophosphatase/phosphodiesterase; Ganglia, Spinal - metabolism; Gene expression; Immunohistochemistry - methods; Immunoreactivity; Localization; Male; Neurons; Nucleoside transporter; Original Paper; Pain perception; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - metabolism; Purine P2 receptors; Pyrophosphatase; Pyrophosphatases - genetics; Pyrophosphatases - metabolism; Rats; Rats, Sprague-Dawley; Rodents; sensory neuron; Sensory neurons; Sensory Receptor Cells - metabolism; ATP, ectoenzyme; clearance system; sensory neuron; Ecto-nucleotide pyrophosphatase/phosphodiesterase; dorsal root ganglion

In dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R. Thus, the clearance system for adenine nucleotide/nucleoside plays a c...