Specific Histone Lysine 4 Methylation Patterns Define TR-Binding Capacity and Differentiate Direct T3 Responses
Abstract The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T3 and its receptors on transcription does not reflect this diversity. Here, T3-dependent amphibian metamorphosis was exploited to investig...
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| Published in | Molecular endocrinology (Baltimore, Md.) Vol. 25; no. 2; pp. 225 - 237 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.02.2011
Endocrine Society |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract
The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T3 and its receptors on transcription does not reflect this diversity. Here, T3-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T3 directly regulates gene expression. Two, direct positively regulated T3-response genes encoding transcription factors were analyzed: thyroid hormone receptor β (TRβ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TRβ) and differences in induction after T3 treatment (lower for TRβ than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T3 differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T3 -responsive elements (higher for TRβ than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TRβ than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T3 responses. |
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| AbstractList | The diversity of thyroid hormone T(3) effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T(3) and its receptors on transcription does not reflect this diversity. Here, T(3)-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T(3) directly regulates gene expression. Two, direct positively regulated T(3)-response genes encoding transcription factors were analyzed: thyroid hormone receptor β (TRβ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TRβ) and differences in induction after T(3) treatment (lower for TRβ than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T(3) differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T(3) -responsive elements (higher for TRβ than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TRβ than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T(3) responses.The diversity of thyroid hormone T(3) effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T(3) and its receptors on transcription does not reflect this diversity. Here, T(3)-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T(3) directly regulates gene expression. Two, direct positively regulated T(3)-response genes encoding transcription factors were analyzed: thyroid hormone receptor β (TRβ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TRβ) and differences in induction after T(3) treatment (lower for TRβ than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T(3) differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T(3) -responsive elements (higher for TRβ than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TRβ than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T(3) responses. The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T3 and its receptors on transcription does not reflect this diversity. Here, T3-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T3 directly regulates gene expression. Two, direct positively regulated T3-response genes encoding transcription factors were analyzed: thyroid hormone receptor beta (TR beta ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TR beta ) and differences in induction after T3 treatment (lower for TR beta than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T3 differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T3 -responsive elements (higher for TR beta than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TR beta than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T3 responses. The diversity of thyroid hormone T(3) effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T(3) and its receptors on transcription does not reflect this diversity. Here, T(3)-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T(3) directly regulates gene expression. Two, direct positively regulated T(3)-response genes encoding transcription factors were analyzed: thyroid hormone receptor β (TRβ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TRβ) and differences in induction after T(3) treatment (lower for TRβ than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T(3) differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T(3) -responsive elements (higher for TRβ than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TRβ than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T(3) responses. The histone code, notably H3 methylation, contributes to the precise control of gene expression that underlies complex physiological T 3 responses. The diversity of thyroid hormone T 3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T 3 and its receptors on transcription does not reflect this diversity. Here, T 3 -dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T 3 directly regulates gene expression. Two, direct positively regulated T 3 -response genes encoding transcription factors were analyzed: thyroid hormone receptor β ( TR β) and TH/bZIP . Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TR β) and differences in induction after T 3 treatment (lower for TR β than for TH/bZIP ). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T 3 differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T 3 -responsive elements (higher for TR β than for TH/bZIP ), correlated with gene-specific modifications of H3K4 methylation (higher for TR β than for TH/bZIP ). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T 3 responses. Abstract The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T3 and its receptors on transcription does not reflect this diversity. Here, T3-dependent amphibian metamorphosis was exploited to investigate, in an in vivo developmental context, how T3 directly regulates gene expression. Two, direct positively regulated T3-response genes encoding transcription factors were analyzed: thyroid hormone receptor β (TRβ) and TH/bZIP. Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/bZIP than for TRβ) and differences in induction after T3 treatment (lower for TRβ than for TH/bZIP). To dissect the mechanisms underlying these differences, chromatin immunoprecipitation was used. T3 differentially induced RNA polymerase II and histone tail acetylation as a function of transcriptional level. Gene-specific patterns of TR binding were found on the different T3 -responsive elements (higher for TRβ than for TH/bZIP), correlated with gene-specific modifications of H3K4 methylation (higher for TRβ than for TH/bZIP). Moreover, tissue-specific modifications of H3K27 were found (lower in brain than in tail fin). This first in vivo analysis of the association of histone modifications and TR binding/gene activation during vertebrate development for any nuclear receptor indicate that chromatin context of thyroid-responsive elements loci controls the capacity to bind TR through variations in histone H3K4 methylation, and that the histone code, notably H3, contributes to the fine tuning of gene expression that underlies complex physiological T3 responses. |
| Author | Sachs, Laurent M. Buisine, Nicolas Jolivet, Pascale Demeneix, Barbara A. Bilesimo, Patrice Alfama, Gladys Mevel, Sebastien Le Havis, Emmanuelle |
| Author_xml | – sequence: 1 givenname: Patrice surname: Bilesimo fullname: Bilesimo, Patrice organization: 2WatchFrog S.A. (P.B.), 91000 Evry, France – sequence: 2 givenname: Pascale surname: Jolivet fullname: Jolivet, Pascale organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 3 givenname: Gladys surname: Alfama fullname: Alfama, Gladys organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 4 givenname: Nicolas surname: Buisine fullname: Buisine, Nicolas organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 5 givenname: Sebastien Le surname: Mevel fullname: Mevel, Sebastien Le organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 6 givenname: Emmanuelle surname: Havis fullname: Havis, Emmanuelle organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 7 givenname: Barbara A. surname: Demeneix fullname: Demeneix, Barbara A. organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France – sequence: 8 givenname: Laurent M. surname: Sachs fullname: Sachs, Laurent M. email: sachs@mnhn.fr organization: 1Muséum National d'Histoire Naturelle (P.B., P.J., G.A., N.B., S.L.M., E.H., B.A.D., L.M.S.), Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique (CNRS), Evolution des régulations endocriniennes, 75231 Paris cedex 05, France |
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| Keywords | TR-α | TR-β Thyroid hormone |
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| Snippet | Abstract
The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action... The diversity of thyroid hormone T(3) effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T(3)... The diversity of thyroid hormone T3 effects in vivo makes their molecular analysis particularly challenging. Indeed, the current model of the action of T3 and... The histone code, notably H3 methylation, contributes to the precise control of gene expression that underlies complex physiological T 3 responses. The... |
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| SubjectTerms | Acetylation Animals Animals, Genetically Modified Basic-Leucine Zipper Transcription Factors - genetics Chromatin Immunoprecipitation Gene Expression Regulation, Developmental Histones - genetics Histones - metabolism Larva - genetics Life Sciences Methylation Original Research Polymerase Chain Reaction Promoter Regions, Genetic RNA Polymerase II - metabolism Thyroid Hormone Receptors beta - genetics Thyroid Hormone Receptors beta - metabolism Transcription, Genetic Triiodothyronine - metabolism Xenopus Xenopus tropicalis |
| Title | Specific Histone Lysine 4 Methylation Patterns Define TR-Binding Capacity and Differentiate Direct T3 Responses |
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