The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

• Published in: Nucleic acids research Vol. 27; no. 11; pp. 2291 - 2298
• Main Authors: Robertson, Keith D., Uzvolgyi, Eva, Liang, Gangning, Talmadge, Cathy, Sumegi, Janos, Gonzales, Felicidad A., Jones, Peter A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.1999; Oxford Publishing Limited (England)
• Subjects: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 20; Colonic Neoplasms - enzymology; Colonic Neoplasms - genetics; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA, Complementary; Gene Expression; Humans; Kidney Neoplasms - enzymology; Kidney Neoplasms - genetics; Mice; Molecular Sequence Data; Pancreatic Neoplasms - enzymology; Pancreatic Neoplasms - genetics; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - genetics

DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis by improper de novo methylation and silencing of the promoters for...