Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 Positive Feedback Loop Induces Cell Cycle Arrest by Dual PI3K/mTOR Inhibitor PQR309 in Endometrial Cancer Cell Lines - Hsin, I-Lun; Shen, Huang-Pin; Chang, Hui-Yi; Ko, Jiunn-Liang; Wang, Po-Hui (Cells (Basel, Switzerland), 2021)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Autophagy; Autophagy - drug effects; c-Myc; c-Myc protein; Cancer; Cell culture; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell death; Cell Death - drug effects; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell viability; Clinical trials; dual PI3K/mTOR inhibitor; Endometrial cancer; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Endometrium; Feedback; Feedback, Physiological; Female; Flow cytometry; Glucose; Growth factors; Humans; Kinases; Microscopy; Models, Biological; mutant p53; Mutant Proteins - metabolism; Myc protein; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositide-3 Kinase Inhibitors - pharmacology; PQR309; Proteomes; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-myc - metabolism; PTEN protein; R&D; Research & development; Spheroids, Cellular - drug effects; Spheroids, Cellular - metabolism; Spheroids, Cellular - pathology; TOR protein; TOR Serine-Threonine Kinases - metabolism; Tumor cell lines; Tumor Suppressor Protein p53 - metabolism; Minneapolis Minnesota; St Louis Missouri; United Kingdom--UK; Asia; United States--US; Taiwan; Israel; endometrial cancer; mutant p53; dual PI3K/mTOR inhibitor; PQR309; c-Myc