The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 8; p. 2007
• Main Authors: Warren, Tara, McAllister, Roisin, Morgan, Amy, Rai, Taranjit Singh, McGilligan, Victoria, Ennis, Matthew, Page, Christopher, Kelly, Catriona, Peace, Aaron, Corfe, Bernard M., Mc Auley, Mark, Watterson, Steven
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.08.2021; MDPI
• Subjects: Age; Aging; Animals; Arteriosclerosis; Atherosclerosis; Biology; Biosynthesis; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - prevention & control; Cholesterol; Cholesterol - blood; Cholesterol - metabolism; Cholesterol, LDL - metabolism; Dyslipidemias - drug therapy; Dyslipidemias - epidemiology; Dyslipidemias - metabolism; Heart Disease Risk Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Lipid metabolism; Lipids; Lipoproteins; Low density lipoprotein; Low density lipoprotein receptors; Metabolism; Metabolites; Models, Biological; Molecular modelling; Mutation; Pathogenesis; pathway biology; Prognosis; regulation; Review; Risk Assessment; Risk factors; Statins; Supplements; Systems Biology; Vitamin D; Vitamin D - metabolism; Vitamin D - therapeutic use; Vitamin D Deficiency - drug therapy; Vitamin D Deficiency - epidemiology; Vitamin D Deficiency - metabolism; Vitamin deficiency; systems biology; cholesterol; regulation; pathway biology; vitamin D

Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited. Cardiovascular disease is the leading cause of death globally and atherosclerosis, the pathology associated...