Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens

• Published in: European journal of pharmacology Vol. 671; no. 1-3; pp. 107 - 112
• Main Authors: Chen, Wei-Lu, Wei, Hen-Wei, Chiu, Wen-Zan, Kang, Ching-Hui, Lin, Ting-Han, Hung, Chien-Ching, Chen, Ming-Chun, Shieh, Ming-Song, Lee, Chin-Cheng, Lee, Horng-Mo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 05.12.2011; Elsevier
• Subjects: abdominal fat; Abdominal Fat - cytology; Abdominal Fat - drug effects; acyl coenzyme A; Adipose triglyceride lipase; AMP-activated protein kinase; AMP-Activated Protein Kinases; AMP-Activated Protein Kinases - metabolism; animal models; Animals; Biological and medical sciences; biosynthesis; body weight; Body Weight - drug effects; carnitine; Chickens; cholesterol; clinical trials; cytology; drug effects; drug therapy; Eating; Eating - drug effects; egg production; energy; Enzyme Activation; Enzyme Activation - drug effects; Enzyme Induction; Enzyme Induction - drug effects; enzymology; Fatty Acids, Nonesterified; Fatty Acids, Nonesterified - metabolism; fatty liver; fatty-acid synthase; Female; Gastroenterology. Liver. Pancreas. Abdomen; gene expression; Gene Expression Regulation; Gene Expression Regulation - drug effects; genetics; humans; Hyperlipidemias; Hyperlipidemias - drug therapy; Hypolipidemic Agents; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; insulin; Laying hen; laying hens; Lipase; Lipase - biosynthesis; lipid metabolism; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; liver; Liver - drug effects; Liver - enzymology; Liver - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; metabolism; Metformin; Metformin - pharmacology; Metformin - therapeutic use; Non-alcoholic fatty liver disease; Other diseases. Semiology; Oviposition; Oviposition - drug effects; pharmacology; Pharmacology. Drug treatments; phosphorylation; Phosphorylation - drug effects; proteins; therapeutic use; triacylglycerol lipase; triacylglycerols; Adipose triglyceride lipase; Metformin; Non-alcoholic fatty liver disease; AMP-activated protein kinase; Laying hen; Adipose tissue; Liver; Non-specific serine/threonine protein kinase; Triacylglycerol lipase; Hepatic disease; Lipids; Esterases; Hypoglycemic agent; Biguanides; Aves; AMP; Digestive system; Enzyme; Transferases; Metabolism; Carboxylic ester hydrolases; Vertebrata; Non alcoholic steatohepatitis; Hydrolases; Digestive diseases; Chicken; Pharmacokinetics

Although many clinical trials have showed that metformin improves non-alcoholic fatty liver disease, which is a common liver disease associated with hepatic enzyme abnormalities, an animal model is required to investigate the effects of altered gene expression and post-translational processing (prot...