Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens - Chen, Wei-Lu; Wei, Hen-Wei; Chiu, Wen-Zan; Kang, Ching-Hui; Lin, Ting-Han; Hung, Chien-Ching; Chen, Ming-Chun; Shieh, Ming-Song; Lee, Chin-Cheng; Lee, Horng-Mo (European journal of pharmacology, 2011)
Keywords: abdominal fat; Abdominal Fat - cytology; Abdominal Fat - drug effects; acyl coenzyme A; Adipose triglyceride lipase; AMP-activated protein kinase; AMP-Activated Protein Kinases; AMP-Activated Protein Kinases - metabolism; animal models; Animals; Biological and medical sciences; biosynthesis; body weight; Body Weight - drug effects; carnitine; Chickens; cholesterol; clinical trials; cytology; drug effects; drug therapy; Eating; Eating - drug effects; egg production; energy; Enzyme Activation; Enzyme Activation - drug effects; Enzyme Induction; Enzyme Induction - drug effects; enzymology; Fatty Acids, Nonesterified; Fatty Acids, Nonesterified - metabolism; fatty liver; fatty-acid synthase; Female; Gastroenterology. Liver. Pancreas. Abdomen; gene expression; Gene Expression Regulation; Gene Expression Regulation - drug effects; genetics; humans; Hyperlipidemias; Hyperlipidemias - drug therapy; Hypolipidemic Agents; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; insulin; Laying hen; laying hens; Lipase; Lipase - biosynthesis; lipid metabolism; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; liver; Liver - drug effects; Liver - enzymology; Liver - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; metabolism; Metformin; Metformin - pharmacology; Metformin - therapeutic use; Non-alcoholic fatty liver disease; Other diseases. Semiology; Oviposition; Oviposition - drug effects; pharmacology; Pharmacology. Drug treatments; phosphorylation; Phosphorylation - drug effects; proteins; therapeutic use; triacylglycerol lipase; triacylglycerols; Adipose triglyceride lipase; Metformin; Non-alcoholic fatty liver disease; AMP-activated protein kinase; Laying hen; Adipose tissue; Liver; Non-specific serine/threonine protein kinase; Triacylglycerol lipase; Hepatic disease; Lipids; Esterases; Hypoglycemic agent; Biguanides; Aves; AMP; Digestive system; Enzyme; Transferases; Metabolism; Carboxylic ester hydrolases; Vertebrata; Non alcoholic steatohepatitis; Hydrolases