Fibroblast Memory in Development, Homeostasis and Disease

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 11; p. 2840
• Main Authors: Kirk, Thomas, Ahmed, Abubkr, Rognoni, Emanuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.10.2021; MDPI
• Subjects: Binding sites; biological memory; cancer; Cell division; Connective tissue; Connective tissue diseases; Disease; DNA methylation; Embryonic Development; Environmental effects; Epigenetics; Extracellular matrix; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Gene expression; Homeostasis; Humans; Immune system; Inflammation; Inflammation - pathology; Metabolism; Models, Biological; Morphogenesis; Review; Skin; wound healing; fibroblasts; wound healing; biological memory; inflammation; cell fate; epigenetic modification; mechanical stress; cancer; fibrosis; metabolism; positional identity

Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cel...