Telomere Maintenance and the cGAS-STING Pathway in Cancer

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 12; p. 1958
• Main Authors: Ebata, Hiroshi, Loo, Tze Mun, Takahashi, Akiko
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.06.2022; MDPI
• Subjects: ALT; Apoptosis; Cancer; Cancer therapies; Cell division; Cell growth; Cell proliferation; cellular senescence; cGAS-STING; Cyclic GMP; DNA damage; Drug development; Genomes; Humans; Interferon; Membrane Proteins - metabolism; Mitochondria; Mitochondrial DNA; Mutation; Neoplasms - metabolism; Nucleotidyltransferases - metabolism; Proteins; Review; Senescence; Telomerase; Telomerase - metabolism; telomere; Telomere - metabolism; Telomeres; Tumor Microenvironment; Tumors; Yeast; ALT; cancer; cellular senescence; cGAS-STING; DNA damage; telomere

Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them. The machinery required for telomere maintenance, such as telomerase and the alternative lengthening of telomeres (ALT), enables can...