Telomere Maintenance and the cGAS-STING Pathway in Cancer

Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them. The machinery required for telomere maintenance, such as telomerase and the alternative lengthening of telomeres (ALT), enables can...

Full description

Saved in:
Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 11; no. 12; p. 1958
Main Authors Ebata, Hiroshi, Loo, Tze Mun, Takahashi, Akiko
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.06.2022
MDPI
Subjects
ALT
Apoptosis
Cancer
Cancer therapies
Cell division
Cell growth
Cell proliferation
cellular senescence
cGAS-STING
Cyclic GMP
DNA damage
Drug development
Genomes
Humans
Interferon
Membrane Proteins - metabolism
Mitochondria
Mitochondrial DNA
Mutation
Neoplasms - metabolism
Nucleotidyltransferases - metabolism
Proteins
Review
Senescence
Telomerase
Telomerase - metabolism
telomere
Telomere - metabolism
Telomeres
Tumor Microenvironment
Tumors
Yeast
ALT
cancer
cellular senescence
cGAS-STING
DNA damage
telomere
Online AccessGet full text

Cover

Abstract Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them. The machinery required for telomere maintenance, such as telomerase and the alternative lengthening of telomeres (ALT), enables cancer cells to proliferate indefinitely. In addition, the molecules in this system are involved in noncanonical pro-tumorigenic functions. Of these, the function of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which contains telomere-related molecules, is a well-known contributor to the tumor microenvironment (TME). This review summarizes the current knowledge of the role of telomerase and ALT in cancer regulation, with emphasis on their noncanonical roles beyond telomere maintenance. The components of the cGAS-STING pathway are summarized with respect to intercell communication in the TME. Elucidating the underlying functional connection between telomere-related molecules and TME regulation is important for the development of cancer therapeutics that target cancer-specific pathways in different contexts. Finally, strategies for designing new cancer therapies that target cancer cells and the TME are discussed.
AbstractList Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them. The machinery required for telomere maintenance, such as telomerase and the alternative lengthening of telomeres (ALT), enables cancer cells to proliferate indefinitely. In addition, the molecules in this system are involved in noncanonical pro-tumorigenic functions. Of these, the function of the cyclic GMP–AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which contains telomere-related molecules, is a well-known contributor to the tumor microenvironment (TME). This review summarizes the current knowledge of the role of telomerase and ALT in cancer regulation, with emphasis on their noncanonical roles beyond telomere maintenance. The components of the cGAS-STING pathway are summarized with respect to intercell communication in the TME. Elucidating the underlying functional connection between telomere-related molecules and TME regulation is important for the development of cancer therapeutics that target cancer-specific pathways in different contexts. Finally, strategies for designing new cancer therapies that target cancer cells and the TME are discussed.
Author Ebata, Hiroshi
Loo, Tze Mun
Takahashi, Akiko
AuthorAffiliation 2 Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; tzemunloo@jfcr.or.jp
1 Department of Biological Sciences, Faculty of Science, The University of Tokyo, Tokyo 113-0033, Japan; hiroshi.ebata@bs.s.u-tokyo.ac.jp
AuthorAffiliation_xml – name: 2 Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; tzemunloo@jfcr.or.jp
– name: 1 Department of Biological Sciences, Faculty of Science, The University of Tokyo, Tokyo 113-0033, Japan; hiroshi.ebata@bs.s.u-tokyo.ac.jp
Author_xml – sequence: 1
  givenname: Hiroshi
  orcidid: 0000-0003-2109-159X
  surname: Ebata
  fullname: Ebata, Hiroshi
  organization: Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
– sequence: 2
  givenname: Tze Mun
  orcidid: 0000-0001-5725-1423
  surname: Loo
  fullname: Loo, Tze Mun
  organization: Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
– sequence: 3
  givenname: Akiko
  surname: Takahashi
  fullname: Takahashi, Akiko
  organization: Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35741087$$D View this record in MEDLINE/PubMed
BookMark eNpdkU1vEzEQhi1UREvpkStaiQuXbf293gtSFUGI1AJSw9ma9Y6bjTZ2sTdF_fc4pK0afBlr5pnX43nfkqMQAxLyntFzIVp64XAcM2OMs1aZV-SE00bUUtL26MX9mJzlvKblGKYZVW_IsVCNZNQ0J6Rd4hg3mLC6hiFMGCA4rCD01bTCys0vb-qb5eL7vPoJ0-oPPFRDqGY7Jr0jrz2MGc8e4yn59fXLcvatvvoxX8wur2qnZDPVmnqvhZdaAvrOQ6daxaHRLdPKCA69lNxx2nWe8zKg8g6Mkp1E4x2iQHFKFnvdPsLa3qVhA-nBRhjsv0RMtxbSNLgRbWn2vGm70ttJSj0YDmU5WHIase-L1ue91t2222DvMEwJxgPRw0oYVvY23tuWc6aFKgKfHgVS_L3FPNnNkHcuQMC4zZZrw6goz-mCfvwPXcdtCmVVhSqEaShjhar3lEsx54T-eRhG7c5je-Bx4T-8_MEz_eSo-As6paLn
CitedBy_id crossref_primary_10_1016_j_canlet_2023_216409
crossref_primary_10_3389_fphar_2024_1379166
crossref_primary_10_2147_IJN_S448556
crossref_primary_10_3390_metabo13070796
crossref_primary_10_1016_j_cej_2024_153152
Cites_doi 10.1093/nar/gkq525
10.1128/MCB.25.7.2708-2721.2005
10.7554/eLife.18221
10.1074/jbc.C100466200
10.1016/j.cell.2008.03.039
10.3390/ijms21010027
10.1126/science.abi6378
10.1016/j.cell.2008.03.038
10.1158/1078-0432.217.11.1
10.1038/s41586-021-03415-4
10.1073/pnas.0905299106
10.1128/MCB.00379-12
10.1038/ncb3195
10.1073/pnas.1705499114
10.1016/j.radonc.2011.05.039
10.1038/nature12306
10.1038/ncb3586
10.1038/nature25432
10.1038/s41568-019-0238-1
10.1126/science.aaa2630
10.1093/hmg/ddl098
10.1038/nsmb.2033
10.1074/jbc.M000622200
10.1073/pnas.0911267106
10.1016/j.cell.2011.12.028
10.1093/hmg/6.12.2011
10.1016/j.cell.2007.12.032
10.1038/nature12305
10.1074/jbc.RA120.012962
10.1038/nature05327
10.1038/ncb846
10.1091/mbc.e05-09-0903
10.1074/jbc.M701413200
10.1038/s41586-019-0998-5
10.1083/jcb.200411093
10.1038/990141
10.1101/gad.10.14.1822
10.1038/s41467-018-03555-8
10.1016/0014-4827(61)90192-6
10.1093/nar/gkr758
10.1161/ATVBAHA.109.185546
10.1083/jcb.201005160
10.1038/nature10833
10.1158/0008-5472.CAN-10-1588
10.1038/sj.emboj.7600181
10.1038/nature03354
10.1158/0008-5472.CAN-06-3452
10.1038/nature07317
10.1016/j.cmet.2019.02.014
10.1038/s41467-018-06860-4
10.1073/pnas.85.17.6465
10.1016/j.cell.2017.02.031
10.1093/nar/gkw549
10.1038/nature14156
10.1093/nar/gkz652
10.1111/j.1474-9728.2004.00124.x
10.1038/ncb2472
10.1038/s41467-018-05077-9
10.1126/science.7605428
10.1126/science.1165357
10.1038/nature03445
10.1126/science.1232458
10.1158/0008-5472.CAN-06-3672
10.1016/1046-5928(91)90103-P
10.1371/journal.pbio.0020240
10.1158/2159-8290.CD-16-0932
10.1111/acel.12344
10.1016/0092-8674(89)90035-4
10.1038/nature09585
10.1038/82586
10.1073/pnas.1321436111
10.1038/nature24050
10.1038/35059131
10.1038/s41586-018-0784-9
10.1016/S0378-1119(99)00108-0
10.1016/j.cell.2011.02.012
10.1002/1878-0261.12761
10.1158/2159-8290.CD-16-0241
10.1128/MCB.23.13.4598-4610.2003
10.1038/nm1197-1271
10.1016/S1476-5586(03)80051-9
10.1126/science.1091496
10.1126/science.1108297
10.1007/BF01957367
10.3390/ijms20061509
10.1016/j.cell.2010.05.021
10.1038/nature03443
10.1371/journal.pgen.1003277
10.1016/j.molcel.2009.02.020
10.1371/journal.pbio.2000016
10.1038/nature23449
10.1128/MCB.20.23.9028-9040.2000
10.1101/gad.1782209
10.1038/ncomms11932
10.1038/nature12640
10.1242/jcs.025742
10.1038/nrc3365
10.1038/s41586-022-04582-8
10.1242/jcs.019372
10.1038/nature06337
10.1016/0022-2836(92)90096-3
10.1128/MCB.20.9.3037-3048.2000
10.1016/j.cell.2014.08.030
10.1158/2159-8290.CD-18-0689
10.1091/mbc.e11-10-0884
10.1038/s41467-018-04010-4
10.1007/s10522-013-9477-9
10.1038/386623a0
10.1093/jnci/djq364
10.1002/bit.260110607
10.1038/ncomms13980
10.1016/S1097-2765(03)00196-5
10.1038/nsmb.1725
10.1091/mbc.e05-09-0904
10.1002/ijc.23412
10.1038/277665a0
10.1101/gad.12.4.527
10.1126/science.1207313
10.18632/oncotarget.10384
10.1038/ncomms15728
10.1038/nsmb.3498
10.1111/acel.13594
10.1155/2017/8060949
10.1126/science.959840
10.1038/ncomms15287
10.1186/1471-2199-7-26
10.1038/ncb1491
10.1038/nature12347
10.1038/s41418-020-0564-6
10.1016/S0959-8049(97)00062-2
10.1006/excr.1999.4602
10.1038/nature01368
10.1128/MCB.19.11.7461
10.1016/S0140-6736(03)12681-5
10.1016/j.chom.2015.07.001
10.1371/journal.pone.0052989
10.1096/fj.13-230904
10.1128/MCB.00550-12
10.1038/nm.4010
10.1016/S0092-8674(00)80760-6
10.1128/MCB.21.12.4046-4054.2001
10.1007/s13238-021-00879-y
10.1016/S0092-8674(00)81902-9
10.1016/j.celrep.2014.03.006
10.1016/j.cell.2010.03.012
10.1038/377552a0
10.1038/s41586-019-1228-x
10.1016/0092-8674(87)90576-9
10.1007/978-1-4939-8931-7
10.1016/j.cell.2009.07.033
10.1038/s41586-019-1000-2
10.1073/pnas.1704862114
10.1101/gad.2006411
10.1038/ncb2466
10.1111/cas.14266
10.1038/nrg2763
10.1038/nature09787
10.1038/ncomms15618
10.1073/pnas.94.2.514
10.1002/j.1460-2075.1995.tb00098.x
10.1158/0008-5472.CAN-12-3082
10.1038/nature23470
10.1093/nar/gkt729
10.1016/j.cmet.2014.12.003
10.1158/0008-5472.CAN-06-0273
10.1093/nar/gku569
10.1073/pnas.2025647118
10.1038/s41467-020-15719-6
10.1073/pnas.2022600118
ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022 by the authors. 2022
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
8FD
8FE
8FH
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
GNUQQ
HCIFZ
LK8
M7P
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOA
DOI 10.3390/cells11121958
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Biological Science Database
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest Biological Science Collection
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
Biotechnology and BioEngineering Abstracts
ProQuest Central
Genetics Abstracts
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
Engineering Research Database
ProQuest One Academic
MEDLINE - Academic
DatabaseTitleList
CrossRef

Publicly Available Content Database
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2073-4409
ExternalDocumentID oai_doaj_org_article_5fcf279be8fb400fa82a112e2796eedd
10_3390_cells11121958
35741087
Genre Journal Article
Review
GrantInformation_xml – fundername: Japan Agency of Medical Research and Development (AMED)-PRIME
  grantid: 19gm6110023h0001
– fundername: Japan Science and Technology Agency (JST)-Moonshot R&D
  grantid: JPMJPS2022
– fundername: Cell Science Research Foundation
– fundername: Japan Society for the Promotion of Science
  grantid: 21J10299; 22H02907; 22K07198
GroupedDBID 53G
5VS
8FE
8FH
AADQD
AAFWJ
ABDBF
ADBBV
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
CGR
CUY
CVF
DIK
EBD
ECM
EIF
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
IHR
ITC
KQ8
LK8
M48
M7P
MODMG
M~E
NPM
OK1
PGMZT
PIMPY
PROAC
RIG
RPM
AAYXX
CITATION
8FD
ABUWG
AZQEC
DWQXO
FR3
GNUQQ
P64
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
ID FETCH-LOGICAL-c547t-60ff63f464aefbfab5952a769165832ad442c20bbf220815fca854b4e8fcee3e3
IEDL.DBID RPM
ISSN 2073-4409
IngestDate Tue Oct 22 15:10:59 EDT 2024
Tue Sep 17 21:17:13 EDT 2024
Fri Aug 16 03:37:12 EDT 2024
Thu Oct 10 14:29:40 EDT 2024
Fri Aug 23 04:31:54 EDT 2024
Tue Oct 29 09:22:56 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords ALT
cancer
cellular senescence
cGAS-STING
DNA damage
telomere
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c547t-60ff63f464aefbfab5952a769165832ad442c20bbf220815fca854b4e8fcee3e3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0001-5725-1423
0000-0003-2109-159X
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221635/
PMID 35741087
PQID 2679687011
PQPubID 2032536
ParticipantIDs doaj_primary_oai_doaj_org_article_5fcf279be8fb400fa82a112e2796eedd
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9221635
proquest_miscellaneous_2681037966
proquest_journals_2679687011
crossref_primary_10_3390_cells11121958
pubmed_primary_35741087
PublicationCentury 2000
PublicationDate 20220617
PublicationDateYYYYMMDD 2022-06-17
PublicationDate_xml – month: 6
  year: 2022
  text: 20220617
  day: 17
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Cells (Basel, Switzerland)
PublicationTitleAlternate Cells
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Richter (ref_6) 1988; 85
Wajapeyee (ref_24) 2008; 132
Bryan (ref_9) 1995; 14
Demaria (ref_163) 2017; 7
Helmink (ref_104) 2011; 469
Fumagalli (ref_141) 2006; 444
Wu (ref_130) 2014; 42
ref_97
Nowell (ref_3) 1976; 194
Zebarjadian (ref_56) 1999; 19
Hu (ref_11) 2012; 148
Liu (ref_61) 2022; 604
Haendeler (ref_73) 2009; 29
Miyata (ref_155) 2021; 118
Fu (ref_52) 2003; 11
Civril (ref_129) 2013; 498
Laberge (ref_173) 2015; 17
Loo (ref_29) 2020; 111
West (ref_135) 2015; 520
Larsen (ref_12) 2022; 376
Kuilman (ref_25) 2008; 133
Wong (ref_42) 2002; 4
Wick (ref_79) 1999; 232
Baar (ref_162) 2017; 169
Cho (ref_109) 2014; 159
Fujii (ref_46) 1991; 2
Saleh (ref_170) 2020; 14
Listerman (ref_84) 2013; 73
Freund (ref_147) 2012; 23
Jeyapalan (ref_91) 2008; 122
Simon (ref_150) 2019; 29
Liu (ref_128) 2015; 347
Shang (ref_121) 2019; 567
Dragon (ref_47) 2000; 20
Rothstein (ref_112) 2012; 14
Santos (ref_69) 2006; 15
Lv (ref_31) 2022; 21
Cesare (ref_107) 2009; 16
Schiff (ref_164) 1979; 277
Henson (ref_89) 2005; 11
Takahashi (ref_145) 2006; 8
Rossiello (ref_17) 2017; 8
Akiyama (ref_65) 2003; 63
ref_71
ref_158
Zhong (ref_92) 2007; 282
Harding (ref_105) 2011; 99
Sansone (ref_138) 2017; 114
ref_76
ref_75
Brugarolas (ref_143) 1995; 377
Greider (ref_39) 1987; 51
Acosta (ref_26) 2008; 133
Kakarougkas (ref_108) 2013; 41
Orjalo (ref_175) 2009; 106
Lengauer (ref_4) 1997; 386
Cesare (ref_35) 2010; 11
Aalfs (ref_43) 1995; 154
Wakita (ref_172) 2020; 11
Chang (ref_159) 1999; 59
Ghanim (ref_62) 2021; 593
Santos (ref_68) 2004; 3
Smith (ref_18) 2011; 18
Griffith (ref_20) 1999; 97
Sun (ref_120) 2013; 339
Takasugi (ref_154) 2017; 8
Yang (ref_27) 2017; 114
Harding (ref_131) 2017; 548
ref_83
Ray (ref_19) 2014; 111
Ablasser (ref_119) 2013; 498
ref_81
Ito (ref_149) 2019; 566
Burma (ref_103) 2001; 276
Saitoh (ref_124) 2009; 106
Tan (ref_137) 2015; 21
Schwartzentruber (ref_37) 2012; 482
Mitchell (ref_44) 1999; 402
Dobbs (ref_125) 2015; 18
Stern (ref_60) 2012; 32
Abdisalaam (ref_30) 2020; 295
Serrano (ref_140) 1997; 88
Lee (ref_95) 2005; 308
Szatrowski (ref_7) 1991; 51
Farmer (ref_116) 2005; 434
Lafontaine (ref_55) 1998; 12
Ebata (ref_77) 2021; 2021
Morin (ref_8) 1989; 59
Wang (ref_45) 2004; 23
Kitajima (ref_136) 2019; 9
Scheule (ref_165) 1992; 262
Zhang (ref_174) 2018; 9
Compton (ref_34) 2007; 67
Guey (ref_28) 2017; 19
Li (ref_32) 2022; 13
Costa (ref_90) 2006; 66
Zhao (ref_122) 2019; 569
Chen (ref_167) 2018; 9
Bryant (ref_115) 2005; 434
Tycowski (ref_49) 2009; 34
Wallace (ref_134) 2012; 12
Dou (ref_22) 2017; 550
Ding (ref_66) 2013; 27
Ohtani (ref_142) 2001; 409
Shahbandi (ref_171) 2020; 27
Boveri (ref_5) 2008; 121
Oza (ref_110) 2009; 23
Liu (ref_67) 2016; 44
Sartori (ref_99) 2007; 450
Masutomi (ref_51) 2000; 275
Dunham (ref_87) 2000; 26
Lee (ref_133) 2017; 2017
Yakes (ref_2) 1997; 94
Gutkin (ref_33) 2016; 7
Hayflick (ref_1) 1961; 25
Mukai (ref_126) 2016; 7
Beck (ref_148) 2010; 141
Bunting (ref_106) 2010; 141
Richard (ref_57) 2006; 17
Tong (ref_117) 2001; 21
Hisatomi (ref_80) 2003; 5
Rodgers (ref_114) 2005; 434
Ishikawa (ref_123) 2008; 455
Sharma (ref_72) 2012; 40
Jellinek (ref_88) 2003; 361
Han (ref_98) 2021; 118
Mackenzie (ref_13) 2017; 548
Bakhoum (ref_14) 2018; 553
Nehyba (ref_82) 2012; 32
Jiang (ref_93) 2005; 25
Shay (ref_64) 1997; 33
Arcamone (ref_160) 1969; 11
Chiolo (ref_111) 2011; 144
Venteicher (ref_50) 2009; 323
Palacios (ref_118) 2010; 191
Zhu (ref_168) 2015; 14
Indran (ref_74) 2011; 71
McEachern (ref_86) 1996; 10
Ablasser (ref_156) 2013; 503
Levy (ref_21) 1992; 225
Fumagalli (ref_16) 2012; 14
Bryan (ref_85) 1997; 3
Stroik (ref_102) 2019; 47
Liu (ref_166) 2007; 67
Chen (ref_36) 2017; 24
Sahin (ref_113) 2011; 470
Sahai (ref_15) 2020; 20
Alard (ref_132) 2017; 8
Dragon (ref_48) 2000; 20
Imai (ref_146) 2014; 7
Heaphy (ref_38) 2011; 333
Haendeler (ref_10) 2003; 23
Chang (ref_169) 2016; 22
Gilbert (ref_40) 1990; 10
Takahashi (ref_23) 2018; 9
Zhong (ref_59) 2011; 25
Bakkenist (ref_96) 2003; 421
Williams (ref_100) 2009; 139
Ewald (ref_157) 2010; 102
Takahashi (ref_153) 2017; 8
Kim (ref_63) 1994; 266
Torralba (ref_139) 2018; 9
Wright (ref_41) 1999; 251
Wnuk (ref_161) 2014; 15
Ahmed (ref_70) 2008; 121
ref_101
Vogan (ref_53) 2016; 5
Tomlinson (ref_58) 2006; 17
Loo (ref_152) 2017; 7
Kilian (ref_78) 1997; 6
Kim (ref_54) 2010; 38
Zhang (ref_127) 2019; 567
Yoshimoto (ref_151) 2013; 499
Lee (ref_94) 2004; 304
Maehara (ref_144) 2005; 168
References_xml – volume: 38
  start-page: 6746
  year: 2010
  ident: ref_54
  article-title: Effect of Pseudouridylation on the Structure and Activity of the Catalytically Essential P6.1 Hairpin in Human Telomerase RNA
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkq525
  contributor:
    fullname: Kim
– volume: 10
  start-page: 6348
  year: 1990
  ident: ref_40
  article-title: Replication Timing of DNA Sequences Associated with Human Centromeres and Telomeres
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Gilbert
– volume: 25
  start-page: 2708
  year: 2005
  ident: ref_93
  article-title: Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.25.7.2708-2721.2005
  contributor:
    fullname: Jiang
– volume: 5
  start-page: e18221
  year: 2016
  ident: ref_53
  article-title: Minimized Human Telomerase Maintains Telomeres and Resolves Endogenous Roles of H/ACA Proteins, TCAB1, and Cajal Bodies
  publication-title: Elife
  doi: 10.7554/eLife.18221
  contributor:
    fullname: Vogan
– volume: 276
  start-page: 42462
  year: 2001
  ident: ref_103
  article-title: ATM Phosphorylates Histone H2AX in Response to DNA Double-Strand Breaks
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.C100466200
  contributor:
    fullname: Burma
– volume: 133
  start-page: 1019
  year: 2008
  ident: ref_25
  article-title: Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.039
  contributor:
    fullname: Kuilman
– ident: ref_76
  doi: 10.3390/ijms21010027
– volume: 376
  start-page: 476
  year: 2022
  ident: ref_12
  article-title: Cancer Cells Use Self-Inflicted DNA Breaks to Evade Growth Limits Imposed by Genotoxic Stress
  publication-title: Science
  doi: 10.1126/science.abi6378
  contributor:
    fullname: Larsen
– volume: 133
  start-page: 1006
  year: 2008
  ident: ref_26
  article-title: Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.038
  contributor:
    fullname: Acosta
– volume: 11
  start-page: 217
  year: 2005
  ident: ref_89
  article-title: A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.217.11.1
  contributor:
    fullname: Henson
– volume: 593
  start-page: 449
  year: 2021
  ident: ref_62
  article-title: Structure of Human Telomerase Holoenzyme with Bound Telomeric DNA
  publication-title: Nature
  doi: 10.1038/s41586-021-03415-4
  contributor:
    fullname: Ghanim
– volume: 106
  start-page: 17031
  year: 2009
  ident: ref_175
  article-title: Cell Surface-Bound IL-1alpha Is an Upstream Regulator of the Senescence-Associated IL-6/IL-8 Cytokine Network
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0905299106
  contributor:
    fullname: Orjalo
– volume: 32
  start-page: 2384
  year: 2012
  ident: ref_60
  article-title: Telomerase Recruitment Requires Both TCAB1 and Cajal Bodies Independently
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00379-12
  contributor:
    fullname: Stern
– volume: 17
  start-page: 1049
  year: 2015
  ident: ref_173
  article-title: MTOR Regulates the pro-Tumorigenic Senescence-Associated Secretory Phenotype by Promoting IL1A Translation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3195
  contributor:
    fullname: Laberge
– volume: 114
  start-page: E4612
  year: 2017
  ident: ref_27
  article-title: cGAS Is Essential for Cellular Senescence
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1705499114
  contributor:
    fullname: Yang
– volume: 99
  start-page: 307
  year: 2011
  ident: ref_105
  article-title: ATM-Dependent Phosphorylation of 53BP1 in Response to Genomic Stress in Oxic and Hypoxic Cells
  publication-title: Radiother. Oncol.
  doi: 10.1016/j.radonc.2011.05.039
  contributor:
    fullname: Harding
– volume: 498
  start-page: 380
  year: 2013
  ident: ref_119
  article-title: cGAS Produces a 2′-5′-Linked Cyclic Dinucleotide Second Messenger That Activates STING
  publication-title: Nature
  doi: 10.1038/nature12306
  contributor:
    fullname: Ablasser
– volume: 19
  start-page: 1061
  year: 2017
  ident: ref_28
  article-title: Innate Immune Sensing of Cytosolic Chromatin Fragments through cGAS Promotes Senescence
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3586
  contributor:
    fullname: Guey
– volume: 553
  start-page: 467
  year: 2018
  ident: ref_14
  article-title: Chromosomal Instability Drives Metastasis through a Cytosolic DNA Response
  publication-title: Nature
  doi: 10.1038/nature25432
  contributor:
    fullname: Bakhoum
– volume: 20
  start-page: 174
  year: 2020
  ident: ref_15
  article-title: A Framework for Advancing Our Understanding of Cancer-Associated Fibroblasts
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0238-1
  contributor:
    fullname: Sahai
– volume: 347
  start-page: aaa2630
  year: 2015
  ident: ref_128
  article-title: Phosphorylation of Innate Immune Adaptor Proteins MAVS, STING, and TRIF Induces IRF3 Activation
  publication-title: Science
  doi: 10.1126/science.aaa2630
  contributor:
    fullname: Liu
– volume: 15
  start-page: 1757
  year: 2006
  ident: ref_69
  article-title: Mitochondrial Localization of Telomerase as a Determinant for Hydrogen Peroxide-Induced Mitochondrial DNA Damage and Apoptosis
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddl098
  contributor:
    fullname: Santos
– volume: 18
  start-page: 478
  year: 2011
  ident: ref_18
  article-title: Rudimentary G-Quadruplex-Based Telomere Capping in Saccharomyces Cerevisiae
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2033
  contributor:
    fullname: Smith
– volume: 275
  start-page: 22568
  year: 2000
  ident: ref_51
  article-title: Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M000622200
  contributor:
    fullname: Masutomi
– volume: 106
  start-page: 20842
  year: 2009
  ident: ref_124
  article-title: Atg9a Controls dsDNA-Driven Dynamic Translocation of STING and the Innate Immune Response
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0911267106
  contributor:
    fullname: Saitoh
– volume: 262
  start-page: L386
  year: 1992
  ident: ref_165
  article-title: Bleomycin Stimulation of Cytokine Secretion by the Human Alveolar Macrophage
  publication-title: Am. J. Physiol.
  contributor:
    fullname: Scheule
– volume: 148
  start-page: 651
  year: 2012
  ident: ref_11
  article-title: Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2011.12.028
  contributor:
    fullname: Hu
– volume: 6
  start-page: 2011
  year: 1997
  ident: ref_78
  article-title: Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/6.12.2011
  contributor:
    fullname: Kilian
– volume: 132
  start-page: 363
  year: 2008
  ident: ref_24
  article-title: Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
  publication-title: Cell
  doi: 10.1016/j.cell.2007.12.032
  contributor:
    fullname: Wajapeyee
– volume: 498
  start-page: 332
  year: 2013
  ident: ref_129
  article-title: Structural Mechanism of Cytosolic DNA Sensing by cGAS
  publication-title: Nature
  doi: 10.1038/nature12305
  contributor:
    fullname: Civril
– volume: 59
  start-page: 3761
  year: 1999
  ident: ref_159
  article-title: A Senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents
  publication-title: Cancer Res.
  contributor:
    fullname: Chang
– volume: 295
  start-page: 11144
  year: 2020
  ident: ref_30
  article-title: Dysfunctional Telomeres Trigger Cellular Senescence Mediated by Cyclic GMP-AMP Synthase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA120.012962
  contributor:
    fullname: Abdisalaam
– volume: 444
  start-page: 638
  year: 2006
  ident: ref_141
  article-title: Oncogene-Induced Senescence Is a DNA Damage Response Triggered by DNA Hyper-Replication
  publication-title: Nature
  doi: 10.1038/nature05327
  contributor:
    fullname: Fumagalli
– volume: 4
  start-page: 731
  year: 2002
  ident: ref_42
  article-title: Subnuclear Shuttling of Human Telomerase Induced by Transformation and DNA Damage
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb846
  contributor:
    fullname: Wong
– volume: 17
  start-page: 955
  year: 2006
  ident: ref_58
  article-title: Cell Cycle-Regulated Trafficking of Human Telomerase to Telomeres
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e05-09-0903
  contributor:
    fullname: Tomlinson
– volume: 282
  start-page: 29314
  year: 2007
  ident: ref_92
  article-title: Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of Telomeres
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M701413200
  contributor:
    fullname: Zhong
– volume: 567
  start-page: 389
  year: 2019
  ident: ref_121
  article-title: Cryo-EM Structures of STING Reveal Its Mechanism of Activation by Cyclic GMP–AMP
  publication-title: Nature
  doi: 10.1038/s41586-019-0998-5
  contributor:
    fullname: Shang
– volume: 168
  start-page: 553
  year: 2005
  ident: ref_144
  article-title: Reduction of Total E2F/DP Activity Induces Senescence-like Cell Cycle Arrest in Cancer Cells Lacking Functional pRB and p53
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200411093
  contributor:
    fullname: Maehara
– volume: 402
  start-page: 551
  year: 1999
  ident: ref_44
  article-title: A Telomerase Component Is Defective in the Human Disease Dyskeratosis Congenita
  publication-title: Nature
  doi: 10.1038/990141
  contributor:
    fullname: Mitchell
– volume: 10
  start-page: 1822
  year: 1996
  ident: ref_86
  article-title: Cap-Prevented Recombination between Terminal Telomeric Repeat Arrays (telomere CPR) Maintains Telomeres in Kluyveromyces Lactis Lacking Telomerase
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.14.1822
  contributor:
    fullname: McEachern
– volume: 9
  start-page: 1249
  year: 2018
  ident: ref_23
  article-title: Downregulation of Cytoplasmic DNases Is Implicated in Cytoplasmic DNA Accumulation and SASP in Senescent Cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03555-8
  contributor:
    fullname: Takahashi
– volume: 25
  start-page: 585
  year: 1961
  ident: ref_1
  article-title: The Serial Cultivation of Human Diploid Cell Strains
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(61)90192-6
  contributor:
    fullname: Hayflick
– volume: 40
  start-page: 712
  year: 2012
  ident: ref_72
  article-title: Human Telomerase Acts as a hTR-Independent Reverse Transcriptase in Mitochondria
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr758
  contributor:
    fullname: Sharma
– volume: 29
  start-page: 929
  year: 2009
  ident: ref_73
  article-title: Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function from Damage
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.109.185546
  contributor:
    fullname: Haendeler
– volume: 191
  start-page: 1299
  year: 2010
  ident: ref_118
  article-title: SIRT1 Contributes to Telomere Maintenance and Augments Global Homologous Recombination
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201005160
  contributor:
    fullname: Palacios
– volume: 482
  start-page: 226
  year: 2012
  ident: ref_37
  article-title: Driver Mutations in Histone H3.3 and Chromatin Remodelling Genes in Paediatric Glioblastoma
  publication-title: Nature
  doi: 10.1038/nature10833
  contributor:
    fullname: Schwartzentruber
– volume: 71
  start-page: 266
  year: 2011
  ident: ref_74
  article-title: hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-1588
  contributor:
    fullname: Indran
– volume: 23
  start-page: 1857
  year: 2004
  ident: ref_45
  article-title: Architecture and Assembly of Mammalian H/ACA Small Nucleolar and Telomerase Ribonucleoproteins
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600181
  contributor:
    fullname: Wang
– volume: 434
  start-page: 113
  year: 2005
  ident: ref_114
  article-title: Nutrient Control of Glucose Homeostasis through a Complex of PGC-1alpha and SIRT1
  publication-title: Nature
  doi: 10.1038/nature03354
  contributor:
    fullname: Rodgers
– volume: 67
  start-page: 3117
  year: 2007
  ident: ref_166
  article-title: Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-3452
  contributor:
    fullname: Liu
– volume: 455
  start-page: 674
  year: 2008
  ident: ref_123
  article-title: STING Is an Endoplasmic Reticulum Adaptor That Facilitates Innate Immune Signalling
  publication-title: Nature
  doi: 10.1038/nature07317
  contributor:
    fullname: Ishikawa
– volume: 29
  start-page: 871
  year: 2019
  ident: ref_150
  article-title: LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2019.02.014
  contributor:
    fullname: Simon
– volume: 9
  start-page: 4315
  year: 2018
  ident: ref_167
  article-title: Targeting SPINK1 in the Damaged Tumour Microenvironment Alleviates Therapeutic Resistance
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06860-4
  contributor:
    fullname: Chen
– volume: 85
  start-page: 6465
  year: 1988
  ident: ref_6
  article-title: Normal Oxidative Damage to Mitochondrial and Nuclear DNA Is Extensive
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.85.17.6465
  contributor:
    fullname: Richter
– volume: 169
  start-page: 132
  year: 2017
  ident: ref_162
  article-title: Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
  publication-title: Cell
  doi: 10.1016/j.cell.2017.02.031
  contributor:
    fullname: Baar
– volume: 44
  start-page: 8693
  year: 2016
  ident: ref_67
  article-title: hTERT Promotes Tumor Angiogenesis by Activating VEGF via Interactions with the Sp1 Transcription Factor
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw549
  contributor:
    fullname: Liu
– volume: 520
  start-page: 553
  year: 2015
  ident: ref_135
  article-title: Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response
  publication-title: Nature
  doi: 10.1038/nature14156
  contributor:
    fullname: West
– volume: 47
  start-page: 8927
  year: 2019
  ident: ref_102
  article-title: CtIP Is Essential for Telomere Replication
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz652
  contributor:
    fullname: Stroik
– volume: 3
  start-page: 399
  year: 2004
  ident: ref_68
  article-title: Mitochondrial hTERT Exacerbates Free-Radical-Mediated mtDNA Damage
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9728.2004.00124.x
  contributor:
    fullname: Santos
– volume: 14
  start-page: 510
  year: 2012
  ident: ref_112
  article-title: Increased Chromosome Mobility Facilitates Homology Search during Recombination
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2472
  contributor:
    fullname: Rothstein
– volume: 9
  start-page: 2658
  year: 2018
  ident: ref_139
  article-title: Priming of Dendritic Cells by DNA-Containing Extracellular Vesicles from Activated T Cells through Antigen-Driven Contacts
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05077-9
  contributor:
    fullname: Torralba
– volume: 266
  start-page: 2011
  year: 1994
  ident: ref_63
  article-title: Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
  publication-title: Science
  doi: 10.1126/science.7605428
  contributor:
    fullname: Kim
– volume: 323
  start-page: 644
  year: 2009
  ident: ref_50
  article-title: A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
  publication-title: Science
  doi: 10.1126/science.1165357
  contributor:
    fullname: Venteicher
– volume: 434
  start-page: 917
  year: 2005
  ident: ref_116
  article-title: Targeting the DNA Repair Defect in BRCA Mutant Cells as a Therapeutic Strategy
  publication-title: Nature
  doi: 10.1038/nature03445
  contributor:
    fullname: Farmer
– volume: 339
  start-page: 786
  year: 2013
  ident: ref_120
  article-title: Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
  publication-title: Science
  doi: 10.1126/science.1232458
  contributor:
    fullname: Sun
– volume: 51
  start-page: 794
  year: 1991
  ident: ref_7
  article-title: Production of Large Amounts of Hydrogen Peroxide by Human Tumor Cells1
  publication-title: Cancer Res.
  contributor:
    fullname: Szatrowski
– volume: 67
  start-page: 1513
  year: 2007
  ident: ref_34
  article-title: Xrcc3 and Nbs1 Are Required for the Production of Extrachromosomal Telomeric Circles in Human Alternative Lengthening of Telomere Cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-3672
  contributor:
    fullname: Compton
– volume: 2
  start-page: 420
  year: 1991
  ident: ref_46
  article-title: Stable Preparation of Aldose Reductase Isoenzymes from Human Placenta
  publication-title: Protein Expr. Purif.
  doi: 10.1016/1046-5928(91)90103-P
  contributor:
    fullname: Fujii
– ident: ref_101
  doi: 10.1371/journal.pbio.0020240
– volume: 7
  start-page: 522
  year: 2017
  ident: ref_152
  article-title: Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-16-0932
  contributor:
    fullname: Loo
– volume: 14
  start-page: 644
  year: 2015
  ident: ref_168
  article-title: The Achilles’ Heel of Senescent Cells: From Transcriptome to Senolytic Drugs
  publication-title: Aging Cell
  doi: 10.1111/acel.12344
  contributor:
    fullname: Zhu
– volume: 59
  start-page: 521
  year: 1989
  ident: ref_8
  article-title: The Human Telomere Terminal Transferase Enzyme Is a Ribonucleoprotein That Synthesizes TTAGGG Repeats
  publication-title: Cell
  doi: 10.1016/0092-8674(89)90035-4
  contributor:
    fullname: Morin
– volume: 469
  start-page: 245
  year: 2011
  ident: ref_104
  article-title: H2AX Prevents CtIP-Mediated DNA End Resection and Aberrant Repair in G1-Phase Lymphocytes
  publication-title: Nature
  doi: 10.1038/nature09585
  contributor:
    fullname: Helmink
– volume: 26
  start-page: 447
  year: 2000
  ident: ref_87
  article-title: Telomere Maintenance by Recombination in Human Cells
  publication-title: Nat. Genet.
  doi: 10.1038/82586
  contributor:
    fullname: Dunham
– volume: 111
  start-page: 2990
  year: 2014
  ident: ref_19
  article-title: G-Quadruplex Formation in Telomeres Enhances POT1/TPP1 Protection against RPA Binding
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1321436111
  contributor:
    fullname: Ray
– volume: 550
  start-page: 402
  year: 2017
  ident: ref_22
  article-title: Cytoplasmic Chromatin Triggers Inflammation in Senescence and Cancer
  publication-title: Nature
  doi: 10.1038/nature24050
  contributor:
    fullname: Dou
– volume: 409
  start-page: 1067
  year: 2001
  ident: ref_142
  article-title: Opposing Effects of Ets and Id Proteins on p16INK4a Expression during Cellular Senescence
  publication-title: Nature
  doi: 10.1038/35059131
  contributor:
    fullname: Ohtani
– volume: 566
  start-page: 73
  year: 2019
  ident: ref_149
  article-title: L1 Drives IFN in Senescent Cells and Promotes Age-Associated Inflammation
  publication-title: Nature
  doi: 10.1038/s41586-018-0784-9
  contributor:
    fullname: Ito
– volume: 232
  start-page: 97
  year: 1999
  ident: ref_79
  article-title: Genomic Organization and Promoter Characterization of the Gene Encoding the Human Telomerase Reverse Transcriptase (hTERT)
  publication-title: Gene
  doi: 10.1016/S0378-1119(99)00108-0
  contributor:
    fullname: Wick
– volume: 144
  start-page: 732
  year: 2011
  ident: ref_111
  article-title: Double-Strand Breaks in Heterochromatin Move outside of a Dynamic HP1a Domain to Complete Recombinational Repair
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.012
  contributor:
    fullname: Chiolo
– volume: 14
  start-page: 2504
  year: 2020
  ident: ref_170
  article-title: Clearance of Therapy-Induced Senescent Tumor Cells by the Senolytic ABT-263 via Interference with BCL-XL -BAX Interaction
  publication-title: Mol. Oncol.
  doi: 10.1002/1878-0261.12761
  contributor:
    fullname: Saleh
– volume: 7
  start-page: 165
  year: 2017
  ident: ref_163
  article-title: Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-16-0241
  contributor:
    fullname: Demaria
– volume: 63
  start-page: 18
  year: 2003
  ident: ref_65
  article-title: Nuclear Factor-kappaB p65 Mediates Tumor Necrosis Factor Alpha-Induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein
  publication-title: Cancer Res.
  contributor:
    fullname: Akiyama
– volume: 23
  start-page: 4598
  year: 2003
  ident: ref_10
  article-title: Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.23.13.4598-4610.2003
  contributor:
    fullname: Haendeler
– volume: 3
  start-page: 1271
  year: 1997
  ident: ref_85
  article-title: Evidence for an Alternative Mechanism for Maintaining Telomere Length in Human Tumors and Tumor-Derived Cell Lines
  publication-title: Nat. Med.
  doi: 10.1038/nm1197-1271
  contributor:
    fullname: Bryan
– volume: 5
  start-page: 193
  year: 2003
  ident: ref_80
  article-title: Expression Profile of a Gamma-Deletion Variant of the Human Telomerase Reverse Transcriptase Gene
  publication-title: Neoplasia
  doi: 10.1016/S1476-5586(03)80051-9
  contributor:
    fullname: Hisatomi
– volume: 304
  start-page: 93
  year: 2004
  ident: ref_94
  article-title: Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex
  publication-title: Science
  doi: 10.1126/science.1091496
  contributor:
    fullname: Lee
– volume: 308
  start-page: 551
  year: 2005
  ident: ref_95
  article-title: ATM Activation by DNA Double-Strand Breaks through the Mre11-Rad50-Nbs1 Complex
  publication-title: Science
  doi: 10.1126/science.1108297
  contributor:
    fullname: Lee
– volume: 154
  start-page: 304
  year: 1995
  ident: ref_43
  article-title: The Hoyeraal-Hreidarsson Syndrome: The Fourth Case of a Separate Entity with Prenatal Growth Retardation, Progressive Pancytopenia and Cerebellar Hypoplasia
  publication-title: Eur. J. Pediatr.
  doi: 10.1007/BF01957367
  contributor:
    fullname: Aalfs
– ident: ref_75
  doi: 10.3390/ijms20061509
– volume: 141
  start-page: 1159
  year: 2010
  ident: ref_148
  article-title: LINE-1 Retrotransposition Activity in Human Genomes
  publication-title: Cell
  doi: 10.1016/j.cell.2010.05.021
  contributor:
    fullname: Beck
– volume: 434
  start-page: 913
  year: 2005
  ident: ref_115
  article-title: Specific Killing of BRCA2-Deficient Tumours with Inhibitors of poly(ADP-Ribose) Polymerase
  publication-title: Nature
  doi: 10.1038/nature03443
  contributor:
    fullname: Bryant
– ident: ref_97
  doi: 10.1371/journal.pgen.1003277
– volume: 34
  start-page: 47
  year: 2009
  ident: ref_49
  article-title: A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.02.020
  contributor:
    fullname: Tycowski
– ident: ref_83
  doi: 10.1371/journal.pbio.2000016
– volume: 548
  start-page: 461
  year: 2017
  ident: ref_13
  article-title: cGAS Surveillance of Micronuclei Links Genome Instability to Innate Immunity
  publication-title: Nature
  doi: 10.1038/nature23449
  contributor:
    fullname: Mackenzie
– volume: 20
  start-page: 9028
  year: 2000
  ident: ref_48
  article-title: Human H/ACA Small Nucleolar RNPs and Telomerase Share Evolutionarily Conserved Proteins NHP2 and NOP10
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.20.23.9028-9040.2000
  contributor:
    fullname: Dragon
– volume: 23
  start-page: 912
  year: 2009
  ident: ref_110
  article-title: Mechanisms That Regulate Localization of a DNA Double-Strand Break to the Nuclear Periphery
  publication-title: Genes Dev.
  doi: 10.1101/gad.1782209
  contributor:
    fullname: Oza
– volume: 7
  start-page: 11932
  year: 2016
  ident: ref_126
  article-title: Activation of STING Requires Palmitoylation at the Golgi
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11932
  contributor:
    fullname: Mukai
– volume: 503
  start-page: 530
  year: 2013
  ident: ref_156
  article-title: Cell Intrinsic Immunity Spreads to Bystander Cells via the Intercellular Transfer of cGAMP
  publication-title: Nature
  doi: 10.1038/nature12640
  contributor:
    fullname: Ablasser
– volume: 121
  start-page: 1
  year: 2008
  ident: ref_5
  article-title: Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and Annotated by Henry Harris
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.025742
  contributor:
    fullname: Boveri
– volume: 12
  start-page: 685
  year: 2012
  ident: ref_134
  article-title: Mitochondria and Cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3365
  contributor:
    fullname: Wallace
– volume: 604
  start-page: 578
  year: 2022
  ident: ref_61
  article-title: Structure of Active Human Telomerase with Telomere Shelterin Protein TPP1
  publication-title: Nature
  doi: 10.1038/s41586-022-04582-8
  contributor:
    fullname: Liu
– volume: 121
  start-page: 1046
  year: 2008
  ident: ref_70
  article-title: Telomerase Does Not Counteract Telomere Shortening but Protects Mitochondrial Function under Oxidative Stress
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.019372
  contributor:
    fullname: Ahmed
– volume: 450
  start-page: 509
  year: 2007
  ident: ref_99
  article-title: Human CtIP Promotes DNA End Resection
  publication-title: Nature
  doi: 10.1038/nature06337
  contributor:
    fullname: Sartori
– volume: 225
  start-page: 951
  year: 1992
  ident: ref_21
  article-title: Telomere End-Replication Problem and Cell Aging
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(92)90096-3
  contributor:
    fullname: Levy
– volume: 20
  start-page: 3037
  year: 2000
  ident: ref_47
  article-title: In Vitro Assembly of Human H/ACA Small Nucleolar RNPs Reveals Unique Features of U17 and Telomerase RNAs
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.20.9.3037-3048.2000
  contributor:
    fullname: Dragon
– volume: 159
  start-page: 108
  year: 2014
  ident: ref_109
  article-title: Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.08.030
  contributor:
    fullname: Cho
– volume: 9
  start-page: 34
  year: 2019
  ident: ref_136
  article-title: Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-18-0689
  contributor:
    fullname: Kitajima
– volume: 23
  start-page: 2066
  year: 2012
  ident: ref_147
  article-title: Lamin B1 Loss Is a Senescence-Associated Biomarker
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e11-10-0884
  contributor:
    fullname: Freund
– volume: 9
  start-page: 1723
  year: 2018
  ident: ref_174
  article-title: The Senescence-Associated Secretory Phenotype Is Potentiated by Feedforward Regulatory Mechanisms Involving Zscan4 and TAK1
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04010-4
  contributor:
    fullname: Zhang
– volume: 15
  start-page: 47
  year: 2014
  ident: ref_161
  article-title: A Comparison of Replicative Senescence and Doxorubicin-Induced Premature Senescence of Vascular Smooth Muscle Cells Isolated from Human Aorta
  publication-title: Biogerontology
  doi: 10.1007/s10522-013-9477-9
  contributor:
    fullname: Wnuk
– volume: 386
  start-page: 623
  year: 1997
  ident: ref_4
  article-title: Genetic Instability in Colorectal Cancers
  publication-title: Nature
  doi: 10.1038/386623a0
  contributor:
    fullname: Lengauer
– volume: 102
  start-page: 1536
  year: 2010
  ident: ref_157
  article-title: Therapy-Induced Senescence in Cancer
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djq364
  contributor:
    fullname: Ewald
– volume: 11
  start-page: 1101
  year: 1969
  ident: ref_160
  article-title: Adriamycin, 14-Hydroxydaunomycin, a New Antitumor Antibiotic from S. Peucetius Var. Caesius
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.260110607
  contributor:
    fullname: Arcamone
– volume: 8
  start-page: 13980
  year: 2017
  ident: ref_17
  article-title: DNA Damage Response Inhibition at Dysfunctional Telomeres by Modulation of Telomeric DNA Damage Response RNAs
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13980
  contributor:
    fullname: Rossiello
– volume: 11
  start-page: 1361
  year: 2003
  ident: ref_52
  article-title: Distinct Biogenesis Pathways for Human Telomerase RNA and H/ACA Small Nucleolar RNAs
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(03)00196-5
  contributor:
    fullname: Fu
– volume: 16
  start-page: 1244
  year: 2009
  ident: ref_107
  article-title: Spontaneous Occurrence of Telomeric DNA Damage Response in the Absence of Chromosome Fusions
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1725
  contributor:
    fullname: Cesare
– volume: 17
  start-page: 944
  year: 2006
  ident: ref_57
  article-title: Cell Cycle-Dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e05-09-0904
  contributor:
    fullname: Richard
– volume: 122
  start-page: 2414
  year: 2008
  ident: ref_91
  article-title: Evidence for Alternative Lengthening of Telomeres in Liposarcomas in the Absence of ALT-Associated PML Bodies
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23412
  contributor:
    fullname: Jeyapalan
– volume: 277
  start-page: 665
  year: 1979
  ident: ref_164
  article-title: Promotion of Microtubule Assembly in Vitro by Taxol
  publication-title: Nature
  doi: 10.1038/277665a0
  contributor:
    fullname: Schiff
– volume: 12
  start-page: 527
  year: 1998
  ident: ref_55
  article-title: The Box H+ACA snoRNAs Carry Cbf5p, the Putative rRNA Pseudouridine Synthase
  publication-title: Genes Dev.
  doi: 10.1101/gad.12.4.527
  contributor:
    fullname: Lafontaine
– volume: 333
  start-page: 425
  year: 2011
  ident: ref_38
  article-title: Altered Telomeres in Tumors with ATRX and DAXX Mutations
  publication-title: Science
  doi: 10.1126/science.1207313
  contributor:
    fullname: Heaphy
– volume: 7
  start-page: 59173
  year: 2016
  ident: ref_33
  article-title: Tumor Cells Derived Exosomes Contain hTERT mRNA and Transform Nonmalignant Fibroblasts into Telomerase Positive Cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.10384
  contributor:
    fullname: Gutkin
– volume: 8
  start-page: 15729
  year: 2017
  ident: ref_154
  article-title: Small Extracellular Vesicles Secreted from Senescent Cells Promote Cancer Cell Proliferation through EphA2
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15728
  contributor:
    fullname: Takasugi
– volume: 24
  start-page: 1124
  year: 2017
  ident: ref_36
  article-title: Extrachromosomal Telomere Repeat DNA Is Linked to ALT Development via cGAS-STING DNA Sensing Pathway
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3498
  contributor:
    fullname: Chen
– volume: 21
  start-page: e13594
  year: 2022
  ident: ref_31
  article-title: Dysfunctional Telomeres through Mitostress-Induced cGAS/STING Activation to Aggravate Immune Senescence and Viral Pneumonia
  publication-title: Aging Cell
  doi: 10.1111/acel.13594
  contributor:
    fullname: Lv
– volume: 2017
  start-page: 8060949
  year: 2017
  ident: ref_133
  article-title: Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2017/8060949
  contributor:
    fullname: Lee
– volume: 194
  start-page: 23
  year: 1976
  ident: ref_3
  article-title: The Clonal Evolution of Tumor Cell Populations
  publication-title: Science
  doi: 10.1126/science.959840
  contributor:
    fullname: Nowell
– volume: 8
  start-page: 15287
  year: 2017
  ident: ref_153
  article-title: Exosomes Maintain Cellular Homeostasis by Excreting Harmful DNA from Cells
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15287
  contributor:
    fullname: Takahashi
– ident: ref_81
  doi: 10.1186/1471-2199-7-26
– volume: 8
  start-page: 1291
  year: 2006
  ident: ref_145
  article-title: Mitogenic Signalling and the p16INK4a-Rb Pathway Cooperate to Enforce Irreversible Cellular Senescence
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1491
  contributor:
    fullname: Takahashi
– volume: 499
  start-page: 97
  year: 2013
  ident: ref_151
  article-title: Obesity-Induced Gut Microbial Metabolite Promotes Liver Cancer through Senescence Secretome
  publication-title: Nature
  doi: 10.1038/nature12347
  contributor:
    fullname: Yoshimoto
– volume: 27
  start-page: 3097
  year: 2020
  ident: ref_171
  article-title: BH3 Mimetics Selectively Eliminate Chemotherapy-Induced Senescent Cells and Improve Response in TP53 Wild-Type Breast Cancer
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-020-0564-6
  contributor:
    fullname: Shahbandi
– volume: 33
  start-page: 787
  year: 1997
  ident: ref_64
  article-title: A Survey of Telomerase Activity in Human Cancer
  publication-title: Eur. J. Cancer
  doi: 10.1016/S0959-8049(97)00062-2
  contributor:
    fullname: Shay
– volume: 251
  start-page: 492
  year: 1999
  ident: ref_41
  article-title: Normal Human Telomeres Are Not Late Replicating
  publication-title: Exp. Cell Res.
  doi: 10.1006/excr.1999.4602
  contributor:
    fullname: Wright
– volume: 421
  start-page: 499
  year: 2003
  ident: ref_96
  article-title: DNA Damage Activates ATM through Intermolecular Autophosphorylation and Dimer Dissociation
  publication-title: Nature
  doi: 10.1038/nature01368
  contributor:
    fullname: Bakkenist
– volume: 19
  start-page: 7461
  year: 1999
  ident: ref_56
  article-title: Point Mutations in Yeast CBF5 Can Abolish in Vivo Pseudouridylation of rRNA
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.11.7461
  contributor:
    fullname: Zebarjadian
– volume: 361
  start-page: 836
  year: 2003
  ident: ref_88
  article-title: Alternative Lengthening of Telomeres and Survival in Patients with Glioblastoma Multiforme
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)12681-5
  contributor:
    fullname: Jellinek
– volume: 18
  start-page: 157
  year: 2015
  ident: ref_125
  article-title: STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.07.001
  contributor:
    fullname: Dobbs
– ident: ref_71
  doi: 10.1371/journal.pone.0052989
– volume: 27
  start-page: 4375
  year: 2013
  ident: ref_66
  article-title: Human Telomerase Reverse Transcriptase Regulates MMP Expression Independently of Telomerase Activity via NF-κB-Dependent Transcription
  publication-title: FASEB J.
  doi: 10.1096/fj.13-230904
  contributor:
    fullname: Ding
– volume: 32
  start-page: 4283
  year: 2012
  ident: ref_82
  article-title: Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00550-12
  contributor:
    fullname: Nehyba
– volume: 22
  start-page: 78
  year: 2016
  ident: ref_169
  article-title: Clearance of Senescent Cells by ABT263 Rejuvenates Aged Hematopoietic Stem Cells in Mice
  publication-title: Nat. Med.
  doi: 10.1038/nm.4010
  contributor:
    fullname: Chang
– volume: 97
  start-page: 503
  year: 1999
  ident: ref_20
  article-title: Mammalian Telomeres End in a Large Duplex Loop
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80760-6
  contributor:
    fullname: Griffith
– volume: 21
  start-page: 4046
  year: 2001
  ident: ref_117
  article-title: DNA Strand Break-Sensing Molecule poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.21.12.4046-4054.2001
  contributor:
    fullname: Tong
– volume: 13
  start-page: 47
  year: 2022
  ident: ref_32
  article-title: cGAS Guards against Chromosome End-to-End Fusions during Mitosis and Facilitates Replicative Senescence
  publication-title: Protein Cell
  doi: 10.1007/s13238-021-00879-y
  contributor:
    fullname: Li
– volume: 88
  start-page: 593
  year: 1997
  ident: ref_140
  article-title: Oncogenic Ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81902-9
  contributor:
    fullname: Serrano
– volume: 7
  start-page: 194
  year: 2014
  ident: ref_146
  article-title: Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.03.006
  contributor:
    fullname: Imai
– volume: 141
  start-page: 243
  year: 2010
  ident: ref_106
  article-title: 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.012
  contributor:
    fullname: Bunting
– volume: 377
  start-page: 552
  year: 1995
  ident: ref_143
  article-title: Radiation-Induced Cell Cycle Arrest Compromised by p21 Deficiency
  publication-title: Nature
  doi: 10.1038/377552a0
  contributor:
    fullname: Brugarolas
– volume: 569
  start-page: 718
  year: 2019
  ident: ref_122
  article-title: A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1
  publication-title: Nature
  doi: 10.1038/s41586-019-1228-x
  contributor:
    fullname: Zhao
– volume: 51
  start-page: 887
  year: 1987
  ident: ref_39
  article-title: The Telomere Terminal Transferase of Tetrahymena Is a Ribonucleoprotein Enzyme with Two Kinds of Primer Specificity
  publication-title: Cell
  doi: 10.1016/0092-8674(87)90576-9
  contributor:
    fullname: Greider
– ident: ref_158
  doi: 10.1007/978-1-4939-8931-7
– volume: 139
  start-page: 87
  year: 2009
  ident: ref_100
  article-title: Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair
  publication-title: Cell
  doi: 10.1016/j.cell.2009.07.033
  contributor:
    fullname: Williams
– volume: 567
  start-page: 394
  year: 2019
  ident: ref_127
  article-title: Structural Basis of STING Binding with and Phosphorylation by TBK1
  publication-title: Nature
  doi: 10.1038/s41586-019-1000-2
  contributor:
    fullname: Zhang
– volume: 114
  start-page: E9066
  year: 2017
  ident: ref_138
  article-title: Packaging and Transfer of Mitochondrial DNA via Exosomes Regulate Escape from Dormancy in Hormonal Therapy-Resistant Breast Cancer
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1704862114
  contributor:
    fullname: Sansone
– volume: 25
  start-page: 11
  year: 2011
  ident: ref_59
  article-title: Disruption of Telomerase Trafficking by TCAB1 Mutation Causes Dyskeratosis Congenita
  publication-title: Genes Dev.
  doi: 10.1101/gad.2006411
  contributor:
    fullname: Zhong
– volume: 14
  start-page: 355
  year: 2012
  ident: ref_16
  article-title: Telomeric DNA Damage Is Irreparable and Causes Persistent DNA-Damage-Response Activation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2466
  contributor:
    fullname: Fumagalli
– volume: 111
  start-page: 304
  year: 2020
  ident: ref_29
  article-title: Cellular Senescence and Senescence-Associated Secretory Phenotype via the cGAS-STING Signaling Pathway in Cancer
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14266
  contributor:
    fullname: Loo
– volume: 11
  start-page: 319
  year: 2010
  ident: ref_35
  article-title: Alternative Lengthening of Telomeres: Models, Mechanisms and Implications
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2763
  contributor:
    fullname: Cesare
– volume: 2021
  start-page: 1
  year: 2021
  ident: ref_77
  article-title: Accumulation of TERT in Mitochondria Shows Two Opposing Effects on Apoptosis
  publication-title: bioRxiv
  contributor:
    fullname: Ebata
– volume: 470
  start-page: 359
  year: 2011
  ident: ref_113
  article-title: Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise
  publication-title: Nature
  doi: 10.1038/nature09787
  contributor:
    fullname: Sahin
– volume: 8
  start-page: 15618
  year: 2017
  ident: ref_132
  article-title: DNA Exonuclease Trex1 Regulates Radiotherapy-Induced Tumour Immunogenicity
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15618
  contributor:
    fullname: Alard
– volume: 94
  start-page: 514
  year: 1997
  ident: ref_2
  article-title: Mitochondrial DNA Damage Is More Extensive and Persists Longer than Nuclear DNA Damage in Human Cells Following Oxidative Stress
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.94.2.514
  contributor:
    fullname: Yakes
– volume: 14
  start-page: 4240
  year: 1995
  ident: ref_9
  article-title: Telomere Elongation in Immortal Human Cells without Detectable Telomerase Activity
  publication-title: EMBO J.
  doi: 10.1002/j.1460-2075.1995.tb00098.x
  contributor:
    fullname: Bryan
– volume: 73
  start-page: 2817
  year: 2013
  ident: ref_84
  article-title: The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-3082
  contributor:
    fullname: Listerman
– volume: 548
  start-page: 466
  year: 2017
  ident: ref_131
  article-title: Mitotic Progression Following DNA Damage Enables Pattern Recognition within Micronuclei
  publication-title: Nature
  doi: 10.1038/nature23470
  contributor:
    fullname: Harding
– volume: 41
  start-page: 9719
  year: 2013
  ident: ref_108
  article-title: Opposing Roles for 53BP1 during Homologous Recombination
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt729
  contributor:
    fullname: Kakarougkas
– volume: 21
  start-page: 81
  year: 2015
  ident: ref_137
  article-title: Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.12.003
  contributor:
    fullname: Tan
– volume: 66
  start-page: 8918
  year: 2006
  ident: ref_90
  article-title: Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-0273
  contributor:
    fullname: Costa
– volume: 42
  start-page: 8243
  year: 2014
  ident: ref_130
  article-title: Molecular Evolutionary and Structural Analysis of the Cytosolic DNA Sensor cGAS and STING
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku569
  contributor:
    fullname: Wu
– volume: 118
  start-page: e2025647118
  year: 2021
  ident: ref_155
  article-title: Pericentromeric Noncoding RNA Changes DNA Binding of CTCF and Inflammatory Gene Expression in Senescence and Cancer
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2025647118
  contributor:
    fullname: Miyata
– volume: 11
  start-page: 1935
  year: 2020
  ident: ref_172
  article-title: A BET Family Protein Degrader Provokes Senolysis by Targeting NHEJ and Autophagy in Senescent Cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-15719-6
  contributor:
    fullname: Wakita
– volume: 118
  start-page: e2022600118
  year: 2021
  ident: ref_98
  article-title: ATM Controls the Extent of DNA End Resection by Eliciting Sequential Posttranslational Modifications of CtIP
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2022600118
  contributor:
    fullname: Han
SSID ssj0000816105
Score 2.312027
SecondaryResourceType review_article
Snippet Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 1958
SubjectTerms ALT
Apoptosis
Cancer
Cancer therapies
Cell division
Cell growth
Cell proliferation
cellular senescence
cGAS-STING
Cyclic GMP
DNA damage
Drug development
Genomes
Humans
Interferon
Membrane Proteins - metabolism
Mitochondria
Mitochondrial DNA
Mutation
Neoplasms - metabolism
Nucleotidyltransferases - metabolism
Proteins
Review
Senescence
Telomerase
Telomerase - metabolism
telomere
Telomere - metabolism
Telomeres
Tumor Microenvironment
Tumors
Yeast
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bS8MwFA4iCL6Id-uNCOJbsc2tzeMczgs4hG2wt5K0CQrayTaR_XvPabexiuCLr0lKk--cJN_J5Qshl0Ja5nF_kMtch4InLjQcDBJLy3WhtIsZ3h1-6qr7gXgcyuHKU194JqyWB66Bu5Y-9yzR1qXegr95kzIDHMFBmoLxvahG30ivBFPVGJwCk4lkLarJIa6_xnXwCXRshuoqjUmo0ur_jWD-PCe5MvF0tsnWnDHSVl3THbLmyl2yUb8hOdsjuu_eRu9u7OiTQe0HFNBw1JQFBWpH87tWL-z1H7p39Bm43peZ0deStrHMeJ8MOrf99n04fw8hzKVIpqGKvFfcCyWM89YbK7VkJlHA8CR0TFMIwXIWWesZAwAAOZNKYQVAB1Mhd_yArJej0h0RWkBEDD5UMKNSobm3uAPKjTXwtY6LJCBXC4Cyj1r2IoNwAZHMGkgG5AbhWxZCteoqAWyYzW2Y_WXDgJwuwM_mXWiSMVzhgtEkjgNyscwG58f_m9KNPrFMivccIWQLyGFtq2VNuASyFKXQlKRhxUZVmznl60slsK0ZA5oqj_-jbSdkk-GNCXzuKDkl69PxpzsDHjO155XLfgPwZ_Gx
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9wwDLe2Q5P2gmCwUQZTJk28VVydpG2eJkB8bBInBIfEW5W0yYYELdwdmvjvZ197xzpNe82H6tpx_LOT2ABflHYY-HxQ6tLESmY-tpIEkmgnTZUanyC_HT4fpWfX6vuNvukCbtPuWuViT5xv1FVTcox8HzngQYsrSb4-PMZcNYpPV7sSGq9hBclTwAGsHB6PLi6XURYuK0EIok2uKcm_3-d4-JQUHDnLSs8YzXP2_wto_n1f8g8DdLIGqx1yFAetqNfhla_fwZu2luTzBpixv2vu_cSLc8s5IDiRhhe2rgRBPFGeHlzFV-Nvo1NxQZjvl30Wt7U44jGTTbg-OR4fncVdXYS41CqbxekwhFQGlSrrgwvWaaPRZikhPU0KaiulsMShcwGRGKBDaXOtnPJ5IJMovXwPg7qp_RaIijxjWksV2jRXRgbHJ6HSOkuzTVJlEewtGFQ8tOkvCnIbmJNFj5MRHDL7loM4a_W8oZn8KDolKIiSgJlxRIijvSPYHC3N99SWkq2uIthZML_oVGlavAg-gs_LblIC_r6tffPEY3J-70iuWwQfWlktKZGaQNMwp1_JelLskdrvqW9_zhNtG0SCq3r7_2R9hLfIbyK4oFG2A4PZ5MnvElKZuU_dcvwNDiPpVQ
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ZT9wwEB5xqBIvVcvVAK2MhHhLu_GRxA8IUVQuCYTErsRbZCc2XYlmISyC_fedSbJbUhCvPpTJ2OP5xsc3ADtSWe7pfFCoXIdSJC40AgckUlboItYu4vR2-PwiPhnIs2t1_Y9SqFXgw5uhHeWTGlS335_vJ_to8HsUcWLI_oO2uB_QZjkRp8zDIidOLrrF1yL9elFOEdr0VMOy-bpXxyvV5P1vIc7_L06-8ERHn-BjCyHZQTPmn2HOlcvwoUkqOVkB3Xe3oz-ucuzcEBkEMWo4ZsqCIdZj-fHBVXjVP704ZpcI_p7MhA1LdkhtqlUYHP3qH56EbYKEMFcyGYdxz_tYeBlL47z1xiqtuElihHwKLdUUUvKc96z1nKMClM9NqqSVLvXoG4UTa7BQjkr3BViBITJOqoKbOJVaeEtHosJYg711VCQB7E4VlN01PBgZxg-kyayjyQB-kvpmjYi-ui4YVTdZaw0ZSuJ5oi0KYnER8SblBvs7LIvRaRcBbE2Vn02nRMZpywuXlygKYHtWjdZA3zelGz1Sm5QePmIMF8B6M1YzSYRC9NRL8VeSzih2RO3WlMPfNeO25hxxq9p4X6xNWOL0OIIyGyVbsDCuHt1XhCxj-62ejH8BCd_rAQ
  priority: 102
  providerName: Scholars Portal
Title Telomere Maintenance and the cGAS-STING Pathway in Cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/35741087
https://www.proquest.com/docview/2679687011
https://search.proquest.com/docview/2681037966
https://pubmed.ncbi.nlm.nih.gov/PMC9221635
https://doaj.org/article/5fcf279be8fb400fa82a112e2796eedd
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCb6wIZehnXdw1sbaEDRm5tYD9s6tkGfQIKgTYHeDMmWtgCNU6Qphv77kX4ESdFTLz7oARMkJZIS-QngUCrLPd0PCpXrUIrEhUagQCJlhS5i7SJOtcODYXx5J6_v1f0GqLYWpkraz-3kuHyYHpeTv1Vu5eM077Z5Yt3RoK85RzdCdTdhExV0JUSvtt8UnZieqvE0BYb0XToCf8I1zQlYZQc-CoVmtEdJdCumqELsf8vNfJ0tuWJ-zj_Dp8ZvZCc1fbuw4cov8KF-SfJlD_TYPcymbu7YwBACBMFoOGbKgqGDx_KLk9vwdnw1vGAj9Pj-mRc2KVmfxsy_wt352bh_GTavIoS5kskijHvex8LLWBrnrTdWacVNEqOfp3B5mkJKnvOetZ5z5IXyuUmVtNKlHg2icOIbbJWz0v0AVmBcjJpUcBOnUgtv6R5UGGtwto6KJICjlkHZYw1-kWHQQEzN1pgawCmxbzmIMKurhtn8T9ZILkNKPE-0RUIs7hzepNzgfIdtMVrqIoD9lvlZs5CeMk7nXLinRFEAv5fduATo_6Z0s2cak1K1IwZuAXyvZbWkpJV1AMmaFNdIXe9Bratgthst-_numb9gh1OxBL10lOzD1mL-7A7QhVnYDmyfng1HN53qCAC_A5l2KjX-D4-_9EY
link.rule.ids 230,315,730,783,787,867,888,2109,2228,21402,24332,27938,27939,33758,33759,43819,53806,53808,74638
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB4VEIJLRXmmhWIkxC1i40cSnypAwPLYFYJF4hbZiU2R2oTuLqr4953ZZBdSVb36oUxmPPbnsf0NwL5Ulns6HxQq16EUiQuNQINEygpdxNpFnN4O9_px915ePqiHJuA2aq5VTufEyURdVDnFyA85BTxwcEXRt-dfIWWNotPVJoXGHCwQVRWO6oXj0_7N7SzKQmklEEHU5JoC9_eHFA8foYNzYllpLUYTzv5_Ac2_70u-W4DOVuBjgxzZUW3qT_DBlauwWOeSfF0DPXA_qp9u6FjPEAcEEWk4ZsqCIcRj-fnRXXg3uOifsxvEfL_NK3sq2Qm1Ga7D_dnp4KQbNnkRwlzJZBzGHe9j4WUsjfPWG6u04iaJEekpdFBTSMlz3rHWc44KUD43qZJWutTjkiic2ID5sirdFrACd8Y4lgpu4lRq4S2dhApjDfbWUZEEcDBVUPZc019kuG0gTWYtTQZwTOqbNSLW6klBNXzMGifIUBLPE21REItzhzcpN9jfYVmMa3URwPZU-VnjSqPszfAB7M2q0Qno-6Z01Qu1Sem9I27dAtisbTWTRCgETZ0UfyVpWbElarumfPo-IdrWnCNcVZ__L9YuLHUHvevs-qJ_9QWWOb2PoORGyTbMj4cvbgdRy9h-bYbmH0g17E8
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9swED9tRZt4mfa9bAyMNO0tauOPJH6agFFgQFWNIvEW2Ym9IbGEtUUT__3uGrcsaOLVH8rlPnw_n-07gE9SWe7pfFCoUsdSZC42AgWSKCt0lWqXcHo7fDpKD8_ltwt1Ee4_zcK1yuWauFioq6akGHmfU8ADlStJ-j5cixh_HX65_h1TBSk6aQ3lNB7DWiZRq3qwtrs_Gn9fRVyoxASiiTbRpsC9fp9i4zM0dk4ZVzqOaZG__3-g8_7dyX-c0fA5PAsoku20Yn8Bj1z9Ep60dSVvX4GeuKvml5s6dmooHwQl1XDM1BVDuMfKg52z-GxyNDpgY8R_f8wtu6zZHo2Zvobz4f5k7zAONRLiUslsHqcD71PhZSqN89Ybq7TiJksR9Sk0VlNJyUs-sNZzjgxQvjS5kla63KN7FE68gV7d1O4dsAp3yahXFTdpLrXwlk5FhbEGZ-ukyiL4vGRQcd2mwihwC0GcLDqcjGCX2LcaRBmsFw3N9EcRDKJASjzPtEVCLK4j3uTc4HyHbSn67SqCjSXzi2BWs-JOCSLYXnWjQdD3Te2aGxqT09tH3MZF8LaV1YoSoRBADXL8lawjxQ6p3Z768uci6bbmHKGrev8wWVvwFLWyODkaHX-AdU5PJajOUbYBvfn0xn1EADO3m0Ez_wI3zvCD
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Telomere+Maintenance+and+the+cGAS-STING+Pathway+in+Cancer&rft.jtitle=Cells+%28Basel%2C+Switzerland%29&rft.au=Ebata%2C+Hiroshi&rft.au=Loo%2C+Tze+Mun&rft.au=Takahashi%2C+Akiko&rft.date=2022-06-17&rft.pub=MDPI+AG&rft.eissn=2073-4409&rft.volume=11&rft.issue=12&rft.spage=1958&rft_id=info:doi/10.3390%2Fcells11121958&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2073-4409&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2073-4409&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2073-4409&client=summon