Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 17; pp. E3462 - E3471
• Main Authors: Hansen, Marianne D., Johnsen, Ingvild B., Stiberg, Kim A., Sherstova, Tatyana, Wakita, Takaji, Richard, Gabriel Mary, Kandasamy, Richard K., Meurs, Eliane F., Anthonsen, Marit W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.04.2017
• Series: PNAS Plus
• Subjects: Autophagy; Biological Sciences; Cellular Biology; Fragmentation; Golgi apparatus; Guanine; Guanine nucleotide exchange factor; Guanosine triphosphatases; Hepatitis; Hepatitis C; Immunity; Intracellular; Life Sciences; Membranes; Microbiology and Parasitology; Phagocytosis; Phosphorylation; PNAS Plus; Replication; Ribonucleic acid; RNA; RNA viruses; Subcellular Processes; Virology; Viruses; HCV; autophagy; Golgi fragmentation; membranous web; IRGM

Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral replication complexes by remodeling host intracellular membranes to a membranous web. The precise composition of these replication complexes and the detailed mechanisms by which they are formed are incompletely unde...