Effect of glycoprotein IIb-IIIa receptor antagonism on platelet membrane glycoproteins after coronary stent placement

• Published in: Thrombosis and haemostasis Vol. 80; no. 6; p. 994
• Main Authors: Gawaz, M, Ruf, A, Neumann, F J, Pogátsa-Murray, G, Dickfeld, T, Zohlnhöfer, D, Schömig, A
• Format: Journal Article
• Language: English
• Published: Germany 01.12.1998
• Subjects: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Aspirin - administration & dosage; Aspirin - adverse effects; Aspirin - therapeutic use; Binding Sites; Blood Platelets - drug effects; Blood Platelets - metabolism; Coronary Disease - blood; Coronary Disease - therapy; Drug Therapy, Combination; Female; Fibrinogen - metabolism; Gene Expression Regulation - drug effects; Hemorrhage - chemically induced; Hemorrhage - prevention & control; Humans; Immunoglobulin Fab Fragments - pharmacology; Immunoglobulin Fab Fragments - therapeutic use; Ligands; Male; Middle Aged; Myocardial Ischemia - prevention & control; P-Selectin - biosynthesis; P-Selectin - genetics; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - therapeutic use; Platelet Count - drug effects; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex - immunology; Platelet Membrane Glycoproteins - biosynthesis; Platelet Membrane Glycoproteins - genetics; Stents; Thrombocytopenia - prevention & control; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - therapeutic use

Platelet membrane glycoproteins play a crucial role in ischemic complications after coronary stenting. Glycoprotein IIb-IIIa blockade reduces adverse clinical events after angioplasty but is associated with rare but profound thrombocytopenia that might increase hemorrhagic complications. Changes in...