Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability

• Published in: Thrombosis and haemostasis Vol. 84; no. 5; p. 865
• Main Authors: Yu, I S, Chen, H J, Lee, Y S, Huang, P H, Lin, S R, Tsai, T W, Lin, S W
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2000
• Subjects: Animals; Embryonic and Fetal Development - genetics; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Liver Regeneration - genetics; Mice; Mice, Knockout; Serine Endopeptidases - deficiency; Serine Endopeptidases - genetics

Hepsin, a liver-enriched novel serine protease, has been implicated in participating with normal cell growth, embryogenesis, and blood coagulation pathway. To study its function in vivo, we have disrupted the mouse hepsin gene by homologous recombination. Targeted disruption of the hepsin gene and a...