Study of a new bone-targeting titanium implant-bone interface
New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was success...
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Published in | International journal of nanomedicine Vol. 11; pp. 6307 - 6324 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.01.2016
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Abstract | New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant-bone interface was also successfully constructed by implanting the delivery system in vivo. The biological effects were evaluated both in vitro and in vivo. The results showed that Ti surfaces with TNT-bone-targeting micelles could promote cytoskeletal spreading, early adhesion, alkaline phosphatase activity, and extracellular osteocalcin concentrations of rat osteoblasts, with concomitant enhanced protein expression of bone morphogenetic protein (BMP)-2. A single-wall bone-defect implant model was established in normal and ovariectomized rats as postmenopausal osteoporosis models. Microcomputed tomography imaging and BMP-2 expression in vivo demonstrated that the implant with a TNT-targeting micelle surface was able to promote bone regeneration and osseointegration in both animal models. Therefore, beneficial biological effects were demonstrated both in vitro and in vivo, which indicated that the bone-targeting effects of micelles greatly enhance the bioavailability of SV on the implant-bone interface, and the provision of SV-loaded targeting micelles alone exhibits the potential for extensive application in improving local bone regeneration and osseointegration, especially in osteoporotic subjects. |
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AbstractList | Xiangning Liu,1,* Ye Zhang,1,* Shaobing Li,2,* Yayu Wang,3 Ting Sun,1 Zejian Li,1 Lizhao Cai,1 Xiaogang Wang,3,* Lei Zhou,2 Renfa Lai1 1The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University, 2The Department of Oral Implantology, Guangdong Provincial Stomatological Hospital, Southern Medical University, 3Department of Cell Biology, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, People's Republic of China *These authors contributed equally to this work Abstract: New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant-bone interface was also successfully constructed by implanting the delivery system in vivo. The biological effects were evaluated both in vitro and in vivo. The results showed that Ti surfaces with TNT-bone-targeting micelles could promote cytoskeletal spreading, early adhesion, alkaline phosphatase activity, and extracellular osteocalcin concentrations of rat osteoblasts, with concomitant enhanced protein expression of bone morphogenetic protein (BMP)-2. A single-wall bone-defect implant model was established in normal and ovariectomized rats as postmenopausal osteoporosis models. Microcomputed tomography imaging and BMP-2 expression in vivo demonstrated that the implant with a TNT-targeting micelle surface was able to promote bone regeneration and osseointegration in both animal models. Therefore, beneficial biological effects were demonstrated both in vitro and in vivo, which indicated that the bone-targeting effects of micelles greatly enhance the bioavailability of SV on the implant-bone interface, and the provision of SV-loaded targeting micelles alone exhibits the potential for extensive application in improving local bone regeneration and osseointegration, especially in osteoporotic subjects. Keywords: bone regeneration, titania nanotubes, targeted drug delivery, orthopedic implant, drug release, micelles New strategies involving bone-targeting titanium (Ti) implant–bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant–bone interface was also successfully constructed by implanting the delivery system in vivo. The biological effects were evaluated both in vitro and in vivo. The results showed that Ti surfaces with TNT–bone-targeting micelles could promote cytoskeletal spreading, early adhesion, alkaline phosphatase activity, and extracellular osteocalcin concentrations of rat osteoblasts, with concomitant enhanced protein expression of bone morphogenetic protein (BMP)-2. A single-wall bone-defect implant model was established in normal and ovariectomized rats as postmenopausal osteoporosis models. Microcomputed tomography imaging and BMP-2 expression in vivo demonstrated that the implant with a TNT-targeting micelle surface was able to promote bone regeneration and osseointegration in both animal models. Therefore, beneficial biological effects were demonstrated both in vitro and in vivo, which indicated that the bone-targeting effects of micelles greatly enhance the bioavailability of SV on the implant–bone interface, and the provision of SV-loaded targeting micelles alone exhibits the potential for extensive application in improving local bone regeneration and osseointegration, especially in osteoporotic subjects. |
Audience | Academic |
Author | Wang, Yayu Liu, Xiangning Cai, Lizhao Li, Shaobing Zhang, Ye Li, Zejian Zhou, Lei Sun, Ting Lai, Renfa Wang, Xiaogang |
AuthorAffiliation | 2 The Department of Oral Implantology, Guangdong Provincial Stomatological Hospital, Southern Medical University 1 The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University 3 Department of Cell Biology, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, People’s Republic of China |
AuthorAffiliation_xml | – name: 2 The Department of Oral Implantology, Guangdong Provincial Stomatological Hospital, Southern Medical University – name: 3 Department of Cell Biology, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, People’s Republic of China – name: 1 The Medical Center of Stomatology, The First Affiliated Hospital of Jinan University |
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Copyright | COPYRIGHT 2016 Dove Medical Press Limited 2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Liu et al. This work is published and licensed by Dove Medical Press Limited 2016 |
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Keywords | bone regeneration targeted drug delivery orthopedic implant titania nanotubes drug release micelles |
Language | English |
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Snippet | New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and... New strategies involving bone-targeting titanium (Ti) implant–bone interface are required to enhance bone regeneration and osseointegration for orthopedic and... Xiangning Liu,1,* Ye Zhang,1,* Shaobing Li,2,* Yayu Wang,3 Ting Sun,1 Zejian Li,1 Lizhao Cai,1 Xiaogang Wang,3,* Lei Zhou,2 Renfa Lai1 1The Medical Center of... |
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SubjectTerms | Animals Bioavailability Bone and Bones - drug effects Bone Morphogenetic Protein 2 - metabolism Bone regeneration Cardiovascular disease Catalysis Cytoskeleton - drug effects Cytoskeleton - metabolism Dental implants Drug delivery systems drug release Drugs Female Hydrodynamics Hydroxyapatite Joint surgery Micelles Nanoparticles Nanotubes - chemistry NMR Nuclear magnetic resonance Original Research orthopedic implant Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoporosis Ovariectomy Polyesters - chemical synthesis Polyesters - chemistry Polymers Prostheses and Implants Rats, Sprague-Dawley Studies targeted drug delivery Tetracycline - pharmacology titania nanotubes Titanium Titanium - pharmacology Transplants & implants X-Ray Microtomography |
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Title | Study of a new bone-targeting titanium implant-bone interface |
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