Umbilical Cord Mesenchymal-Stem-Cell-Derived Exosomes Exhibit Anti-Oxidant and Antiviral Effects as Cell-Free Therapies

• Published in: Viruses Vol. 15; no. 10; p. 2094
• Main Authors: Meng, Yi, Li, Chengcheng, Liang, Yicong, Jiang, Yu, Zhang, Haonan, Ouyang, Jianhua, Zhang, Wen, Deng, Rumei, Tan, Qiuping, Yu, Xiaolan, Luo, Zhen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: Aging; Antibodies; Antioxidants; antiviral activity; Antiviral agents; Antiviral drugs; c-Jun protein; Care and treatment; Cell death; Cell growth; Cell organelles; cell-free therapy; chronic diseases; death; enterovirus; Enterovirus A; Exosomes; Fibroblasts; genes; GTP-binding protein; Health aspects; Hydrogen peroxide; Immunogenicity; Infections; JNK protein; Kinases; Laboratories; MAP kinase; Mesenchymal stem cells; Mitochondrial DNA; mitogen-activated protein kinase; muscles; Musculoskeletal system; NF-κB protein; Oxidants; oxidative damage; Oxidative stress; protein synthesis; Proteins; Reactive oxygen species; Rhabdomyosarcoma; Senescence; Skeletal muscle; Skin; Stem cells; therapeutics; Therapeutics, Experimental; Transcription factors; Umbilical cord; umbilical cord mesenchymal stem cells (ucMSCs); Virus diseases; China; United States > US

The oxidative stress induced by the accumulation of reactive oxygen species (ROS) can lead to cell aging and death. Equally, the skeletal muscle usually hosts enteroviral persistent infection in inflammatory muscle diseases. As excellent bioactive products, the exosomes derived from umbilical cord m...